Ralph S Baric

InstitutionUniversity of North Carolina at Chapel Hill
AddressChapel Hill
North Carolina
United States
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    Publication Timeline
    COVID-19 publications
    Bar chart showing 37 Covid-19 publications, with a maximum of 6 publications in May 2020 and Spetember 2020
    All Publications
    Bar chart showing 320 publications over 30 distinct years, with a maximum of 33 publications in 2020
    These graphs show COVID-19 publications by month since August 2019 and all publications written by authors of COVID-19 publications over the past 30 years.

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    Publication Field Summary
    This graph shows the number and percent of publications by field. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. To see the data as text, click here.
    Publication List
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Katsura H, Sontake V, Tata A, Kobayashi Y, Edwards CE, Heaton BE, Konkimalla A, Asakura T, Mikami Y, Fritch EJ, Lee PJ, Heaton NS, Boucher RC, Randell SH, Baric RS, Tata PR. Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction. Cell Stem Cell. 2020 Oct 21. PMID: 33128895.
      Citations:    
    2. McNamara RP, Caro-Vegas C, Landis JT, Moorad R, Pluta LJ, Eason AB, Thompson C, Bailey A, Villamor FCS, Lange PT, Wong JP, Seltzer T, Seltzer J, Zhou Y, Vahrson W, Juarez A, Meyo JO, Calabre T, Broussard G, Rivera-Soto R, Chappell DL, Baric RS, Damania B, Miller MB, Dittmer DP. High-Density Amplicon Sequencing Identifies Community Spread and Ongoing Evolution of SARS-CoV-2 in the Southern United States. Cell Rep. 2020 Oct 20; 108352. PMID: 33113345.
      Citations:    Fields:    
    3. Edwards CE, Yount BL, Graham RL, Leist SR, Hou YJ, Dinnon KH, Sims AC, Swanstrom J, Gully K, Scobey TD, Cooley MR, Currie CG, Randell SH, Baric RS. Swine acute diarrhea syndrome coronavirus replication in primary human cells reveals potential susceptibility to infection. Proc Natl Acad Sci U S A. 2020 10 27; 117(43):26915-26925. PMID: 33046644.
      Citations:    Fields:    
    4. Citations: 1     Fields:    
    5. Leist SR, Dinnon KH, Schäfer A, Tse LV, Okuda K, Hou YJ, West A, Edwards CE, Sanders W, Fritch EJ, Gully KL, Scobey T, Brown AJ, Sheahan TP, Moorman NJ, Boucher RC, Gralinski LE, Montgomery SA, Baric RS. A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice. Cell. 2020 Sep 23. PMID: 33031744.
      Citations:    Fields:    
    6. Muñoz-Fontela C, Dowling WE, Funnell SGP, Gsell PS, Riveros-Balta AX, Albrecht RA, Andersen H, Baric RS, Carroll MW, Cavaleri M, Qin C, Crozier I, Dallmeier K, de Waal L, de Wit E, Delang L, Dohm E, Duprex WP, Falzarano D, Finch CL, Frieman MB, Graham BS, Gralinski LE, Guilfoyle K, Haagmans BL, Hamilton GA, Hartman AL, Herfst S, Kaptein SJF, Klimstra WB, Knezevic I, Krause PR, Kuhn JH, Le Grand R, Lewis MG, Liu WC, Maisonnasse P, McElroy AK, Munster V, Oreshkova N, Rasmussen AL, Rocha-Pereira J, Rockx B, Rodríguez E, Rogers TF, Salguero FJ, Schotsaert M, Stittelaar KJ, Thibaut HJ, Tseng CT, Vergara-Alert J, Beer M, Brasel T, Chan JFW, García-Sastre A, Neyts J, Perlman S, Reed DS, Richt JA, Roy CJ, Segalés J, et al. Animal models for COVID-19. Nature. 2020 10; 586(7830):509-515. PMID: 32967005.
      Citations:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
    7. Rydyznski Moderbacher C, Ramirez SI, Dan JM, Grifoni A, Hastie KM, Weiskopf D, Belanger S, Abbott RK, Kim C, Choi J, Kato Y, Crotty EG, Kim C, Rawlings SA, Mateus J, Tse LPV, Frazier A, Baric R, Peters B, Greenbaum J, Ollmann Saphire E, Smith DM, Sette A, Crotty S. Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity. Cell. 2020 Sep 16. PMID: 33010815.
      Citations: 3     Fields:    
    8. Li W, Schäfer A, Kulkarni SS, Liu X, Martinez DR, Chen C, Sun Z, Leist SR, Drelich A, Zhang L, Ura ML, Berezuk A, Chittori S, Leopold K, Mannar D, Srivastava SS, Zhu X, Peterson EC, Tseng CT, Mellors JW, Falzarano D, Subramaniam S, Baric RS, Dimitrov DS. High Potency of a Bivalent Human VH Domain in SARS-CoV-2 Animal Models. Cell. 2020 10 15; 183(2):429-441.e16. PMID: 32941803.
      Citations: 3     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    9. Olival KJ, Cryan PM, Amman BR, Baric RS, Blehert DS, Brook CE, Calisher CH, Castle KT, Coleman JTH, Daszak P, Epstein JH, Field H, Frick WF, Gilbert AT, Hayman DTS, Ip HS, Karesh WB, Johnson CK, Kading RC, Kingston T, Lorch JM, Mendenhall IH, Peel AJ, Phelps KL, Plowright RK, Reeder DM, Reichard JD, Sleeman JM, Streicker DG, Towner JS, Wang LF. Possibility for reverse zoonotic transmission of SARS-CoV-2 to free-ranging wildlife: A case study of bats. PLoS Pathog. 2020 09; 16(9):e1008758. PMID: 32881980.
      Citations: 1     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    10. Dinnon KH, Leist SR, Schäfer A, Edwards CE, Martinez DR, Montgomery SA, West A, Yount BL, Hou YJ, Adams LE, Gully KL, Brown AJ, Huang E, Bryant MD, Choong IC, Glenn JS, Gralinski LE, Sheahan TP, Baric RS. A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures. Nature. 2020 10; 586(7830):560-566. PMID: 32854108.
      Citations: 8     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    11. Hassan AO, Kafai NM, Dmitriev IP, Fox JM, Smith BK, Harvey IB, Chen RE, Winkler ES, Wessel AW, Case JB, Kashentseva E, McCune BT, Bailey AL, Zhao H, VanBlargan LA, Dai YN, Ma M, Adams LJ, Shrihari S, Danis JE, Gralinski LE, Hou YJ, Schäfer A, Kim AS, Keeler SP, Weiskopf D, Baric RS, Holtzman MJ, Fremont DH, Curiel DT, Diamond MS. A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2. Cell. 2020 10 01; 183(1):169-184.e13. PMID: 32931734.
      Citations: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    12. Corbett KS, Edwards DK, Leist SR, Abiona OM, Boyoglu-Barnum S, Gillespie RA, Himansu S, Schäfer A, Ziwawo CT, DiPiazza AT, Dinnon KH, Elbashir SM, Shaw CA, Woods A, Fritch EJ, Martinez DR, Bock KW, Minai M, Nagata BM, Hutchinson GB, Wu K, Henry C, Bahl K, Garcia-Dominguez D, Ma L, Renzi I, Kong WP, Schmidt SD, Wang L, Zhang Y, Phung E, Chang LA, Loomis RJ, Altaras NE, Narayanan E, Metkar M, Presnyak V, Liu C, Louder MK, Shi W, Leung K, Yang ES, West A, Gully KL, Stevens LJ, Wang N, Wrapp D, Doria-Rose NA, Stewart-Jones G, Bennett H, Alvarado GS, Nason MC, Ruckwardt TJ, McLellan JS, Denison MR, Chappell JD, Moore IN, Morabito KM, Mascola JR, Baric RS, Carfi A, Graham BS. SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness. Nature. 2020 10; 586(7830):567-571. PMID: 32756549.
      Citations: 19     Fields:    Translation:AnimalsCellsPHPublic Health
    13. Mercado NB, Zahn R, Wegmann F, Loos C, Chandrashekar A, Yu J, Liu J, Peter L, McMahan K, Tostanoski LH, He X, Martinez DR, Rutten L, Bos R, van Manen D, Vellinga J, Custers J, Langedijk JP, Kwaks T, Bakkers MJG, Zuijdgeest D, Rosendahl Huber SK, Atyeo C, Fischinger S, Burke JS, Feldman J, Hauser BM, Caradonna TM, Bondzie EA, Dagotto G, Gebre MS, Hoffman E, Jacob-Dolan C, Kirilova M, Li Z, Lin Z, Mahrokhian SH, Maxfield LF, Nampanya F, Nityanandam R, Nkolola JP, Patel S, Ventura JD, Verrington K, Wan H, Pessaint L, Van Ry A, Blade K, Strasbaugh A, Cabus M, Brown R, Cook A, Zouantchangadou S, Teow E, Andersen H, Lewis MG, Cai Y, Chen B, Schmidt AG, Reeves RK, Baric RS, et al. Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques. Nature. 2020 10; 586(7830):583-588. PMID: 32731257.
      Citations: 20     Fields:    Translation:AnimalsCellsPHPublic Health
    14. Citations: 14     Fields:    Translation:AnimalsCellsPHPublic Health
    15. Citations: 27     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    16. Zost SJ, Gilchuk P, Chen RE, Case JB, Reidy JX, Trivette A, Nargi RS, Sutton RE, Suryadevara N, Chen EC, Binshtein E, Shrihari S, Ostrowski M, Chu HY, Didier JE, MacRenaris KW, Jones T, Day S, Myers L, Eun-Hyung Lee F, Nguyen DC, Sanz I, Martinez DR, Rothlauf PW, Bloyet LM, Whelan SPJ, Baric RS, Thackray LB, Diamond MS, Carnahan RH, Crowe JE. Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein. Nat Med. 2020 09; 26(9):1422-1427. PMID: 32651581.
      Citations: 15     Fields:    Translation:HumansCellsPHPublic Health
    17. Pruijssers AJ, George AS, Schäfer A, Leist SR, Gralinksi LE, Dinnon KH, Yount BL, Agostini ML, Stevens LJ, Chappell JD, Lu X, Hughes TM, Gully K, Martinez DR, Brown AJ, Graham RL, Perry JK, Du Pont V, Pitts J, Ma B, Babusis D, Murakami E, Feng JY, Bilello JP, Porter DP, Cihlar T, Baric RS, Denison MR, Sheahan TP. Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice. Cell Rep. 2020 07 21; 32(3):107940. PMID: 32668216.
      Citations: 20     Fields:    
    18. Citations: 32     Fields:    Translation:HumansCells
    19. Premkumar L, Segovia-Chumbez B, Jadi R, Martinez DR, Raut R, Markmann A, Cornaby C, Bartelt L, Weiss S, Park Y, Edwards CE, Weimer E, Scherer EM, Rouphael N, Edupuganti S, Weiskopf D, Tse LV, Hou YJ, Margolis D, Sette A, Collins MH, Schmitz J, Baric RS, de Silva AM. The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients. Sci Immunol. 2020 06 11; 5(48). PMID: 32527802.
      Citations: 34     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    20. Citations: 55     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    21. Lambert PH, Ambrosino DM, Andersen SR, Baric RS, Black SB, Chen RT, Dekker CL, Didierlaurent AM, Graham BS, Martin SD, Molrine DC, Perlman S, Picard-Fraser PA, Pollard AJ, Qin C, Subbarao K, Cramer JP. Consensus summary report for CEPI/BC March 12-13, 2020 meeting: Assessment of risk of disease enhancement with COVID-19 vaccines. Vaccine. 2020 06 26; 38(31):4783-4791. PMID: 32507409.
      Citations: 9     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    22. Jiang RD, Liu MQ, Chen Y, Shan C, Zhou YW, Shen XR, Li Q, Zhang L, Zhu Y, Si HR, Wang Q, Min J, Wang X, Zhang W, Li B, Zhang HJ, Baric RS, Zhou P, Yang XL, Shi ZL. Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2. Cell. 2020 07 09; 182(1):50-58.e8. PMID: 32516571.
      Citations: 30     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    23. Citations: 69     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    24. Citations: 67     Fields:    Translation:AnimalsCellsPHPublic Health
    25. Graham RL, Baric RS. SARS-CoV-2: Combating Coronavirus Emergence. Immunity. 2020 05 19; 52(5):734-736. PMID: 32392464.
      Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
    26. Tse LV, Meganck RM, Graham RL, Baric RS. The Current and Future State of Vaccines, Antivirals and Gene Therapies Against Emerging Coronaviruses. Front Microbiol. 2020; 11:658. PMID: 32390971.
      Citations:    
    27. Sheahan TP, Sims AC, Zhou S, Graham RL, Pruijssers AJ, Agostini ML, Leist SR, Schäfer A, Dinnon KH, Stevens LJ, Chappell JD, Lu X, Hughes TM, George AS, Hill CS, Montgomery SA, Brown AJ, Bluemling GR, Natchus MG, Saindane M, Kolykhalov AA, Painter G, Harcourt J, Tamin A, Thornburg NJ, Swanstrom R, Denison MR, Baric RS. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci Transl Med. 2020 04 29; 12(541). PMID: 32253226.
      Citations: 70     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    28. Wan Y, Shang J, Graham R, Baric RS, Li F. Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus. J Virol. 2020 03 17; 94(7). PMID: 31996437.
      Citations: 523     Fields:    Translation:HumansAnimalsCells
    29. Shang J, Wan Y, Liu C, Yount B, Gully K, Yang Y, Auerbach A, Peng G, Baric R, Li F. Structure of mouse coronavirus spike protein complexed with receptor reveals mechanism for viral entry. PLoS Pathog. 2020 03; 16(3):e1008392. PMID: 32150576.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    30. Graham JB, Swarts JL, Menachery VD, Gralinski LE, Schäfer A, Plante KS, Morrison CR, Voss KM, Green R, Choonoo G, Jeng S, Miller DR, Mooney MA, McWeeney SK, Ferris MT, Pardo-Manuel de Villena F, Gale M, Heise MT, Baric RS, Lund JM. Immune Predictors of Mortality After Ribonucleic Acid Virus Infection. J Infect Dis. 2020 03 02; 221(6):882-889. PMID: 31621854.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    31. Menachery VD, Dinnon KH, Yount BL, McAnarney ET, Gralinski LE, Hale A, Graham RL, Scobey T, Anthony SJ, Wang L, Graham B, Randell SH, Lipkin WI, Baric RS. Trypsin Treatment Unlocks Barrier for Zoonotic Bat Coronavirus Infection. J Virol. 2020 02 14; 94(5). PMID: 31801868.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    32. Sheahan TP, Sims AC, Leist SR, Schäfer A, Won J, Brown AJ, Montgomery SA, Hogg A, Babusis D, Clarke MO, Spahn JE, Bauer L, Sellers S, Porter D, Feng JY, Cihlar T, Jordan R, Denison MR, Baric RS. Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat Commun. 2020 01 10; 11(1):222. PMID: 31924756.
      Citations: 259     Fields:    Translation:HumansAnimalsCells
    33. Sun Z, Chen C, Li W, Martinez DR, Drelich A, Baek DS, Liu X, Mellors JW, Tseng CT, Baric RS, Dimitrov DS. Potent neutralization of SARS-CoV-2 by human antibody heavy-chain variable domains isolated from a large library with a new stable scaffold. MAbs. 2020 01 01; 12(1):1778435. PMID: 32544372.
      Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
    34. Agostini ML, Pruijssers AJ, Chappell JD, Gribble J, Lu X, Andres EL, Bluemling GR, Lockwood MA, Sheahan TP, Sims AC, Natchus MG, Saindane M, Kolykhalov AA, Painter GR, Baric RS, Denison MR. Small-Molecule Antiviral ß-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance. J Virol. 2019 12 15; 93(24). PMID: 31578288.
      Citations: 11     Fields:    Translation:AnimalsCells
    35. Mitchell HD, Eisfeld AJ, Stratton KG, Heller NC, Bramer LM, Wen J, McDermott JE, Gralinski LE, Sims AC, Le MQ, Baric RS, Kawaoka Y, Waters KM. The Role of EGFR in Influenza Pathogenicity: Multiple Network-Based Approaches to Identify a Key Regulator of Non-lethal Infections. Front Cell Dev Biol. 2019; 7:200. PMID: 31616667.
      Citations:    
    36. Wahl A, De C, Abad Fernandez M, Lenarcic EM, Xu Y, Cockrell AS, Cleary RA, Johnson CE, Schramm NJ, Rank LM, Newsome IG, Vincent HA, Sanders W, Aguilera-Sandoval CR, Boone A, Hildebrand WH, Dayton PA, Baric RS, Pickles RJ, Braunstein M, Moorman NJ, Goonetilleke N, Victor Garcia J. Precision mouse models with expanded tropism for human pathogens. Nat Biotechnol. 2019 10; 37(10):1163-1173. PMID: 31451733.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    37. Leist SR, Jensen KL, Baric RS, Sheahan TP. Increasing the translation of mouse models of MERS coronavirus pathogenesis through kinetic hematological analysis. PLoS One. 2019; 14(7):e0220126. PMID: 31339932.
      Citations:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
    38. Brown AJ, Won JJ, Graham RL, Dinnon KH, Sims AC, Feng JY, Cihlar T, Denison MR, Baric RS, Sheahan TP. Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase. Antiviral Res. 2019 09; 169:104541. PMID: 31233808.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    39. Comar CE, Goldstein SA, Li Y, Yount B, Baric RS, Weiss SR. Antagonism of dsRNA-Induced Innate Immune Pathways by NS4a and NS4b Accessory Proteins during MERS Coronavirus Infection. mBio. 2019 03 26; 10(2). PMID: 30914508.
      Citations: 19     Fields:    Translation:HumansCells
    40. van Doremalen N, Schäfer A, Menachery VD, Letko M, Bushmaker T, Fischer RJ, Figueroa DM, Hanley PW, Saturday G, Baric RS, Munster VJ. SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (Rousettus aegyptiacus). Viruses. 2018 12 19; 10(12). PMID: 30572566.
      Citations: 3     Fields:    Translation:AnimalsCells
    41. Chefer S, Seidel J, Cockrell AS, Yount B, Solomon J, Hagen KR, Liu DX, Huzella LM, Kumar MR, Postnikova E, Bohannon JK, Lackemeyer MG, Cooper K, Endlich-Frazier A, Sharma H, Thomasson D, Bartos C, Sayre PJ, Sims A, Dyall J, Holbrook MR, Jahrling PB, Baric RS, Johnson RF. The Human Sodium Iodide Symporter as a Reporter Gene for Studying Middle East Respiratory Syndrome Coronavirus Pathogenesis. mSphere. 2018 12 12; 3(6). PMID: 30541777.
      Citations: 2     Fields:    Translation:AnimalsCells
    42. Zheng Y, Shang J, Yang Y, Liu C, Wan Y, Geng Q, Wang M, Baric R, Li F. Lysosomal Proteases Are a Determinant of Coronavirus Tropism. J Virol. 2018 12 15; 92(24). PMID: 30258004.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    43. Graham RL, Deming DJ, Deming ME, Yount BL, Baric RS. Evaluation of a recombination-resistant coronavirus as a broadly applicable, rapidly implementable vaccine platform. Commun Biol. 2018; 1:179. PMID: 30393776.
      Citations:    
    44. Nakagawa K, Narayanan K, Wada M, Popov VL, Cajimat M, Baric RS, Makino S. The Endonucleolytic RNA Cleavage Function of nsp1 of Middle East Respiratory Syndrome Coronavirus Promotes the Production of Infectious Virus Particles in Specific Human Cell Lines. J Virol. 2018 11 01; 92(21). PMID: 30111568.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    45. Gralinski LE, Sheahan TP, Morrison TE, Menachery VD, Jensen K, Leist SR, Whitmore A, Heise MT, Baric RS. Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis. mBio. 2018 10 09; 9(5). PMID: 30301856.
      Citations: 93     Fields:    Translation:AnimalsCells
    46. Menachery VD, Gralinski LE, Mitchell HD, Dinnon KH, Leist SR, Yount BL, McAnarney ET, Graham RL, Waters KM, Baric RS. Combination Attenuation Offers Strategy for Live Attenuated Coronavirus Vaccines. J Virol. 2018 09 01; 92(17). PMID: 29976657.
      Citations: 15     Fields:    Translation:AnimalsCells
    47. Davis BM, Foxman B, Monto AS, Baric RS, Martin ET, Uzicanin A, Rainey JJ, Aiello AE. Human coronaviruses and other respiratory infections in young adults on a university campus: Prevalence, symptoms, and shedding. Influenza Other Respir Viruses. 2018 09; 12(5):582-590. PMID: 29660826.
      Citations: 6     Fields:    Translation:HumansCells
    48. Cockrell AS, Leist SR, Douglas MG, Baric RS. Modeling pathogenesis of emergent and pre-emergent human coronaviruses in mice. Mamm Genome. 2018 08; 29(7-8):367-383. PMID: 30043100.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    49. Cockrell AS, Johnson JC, Moore IN, Liu DX, Bock KW, Douglas MG, Graham RL, Solomon J, Torzewski L, Bartos C, Hart R, Baric RS, Johnson RF. A spike-modified Middle East respiratory syndrome coronavirus (MERS-CoV) infectious clone elicits mild respiratory disease in infected rhesus macaques. Sci Rep. 2018 Jul 16; 8(1):10727. PMID: 30013082.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    50. Shin JS, Jung E, Kim M, Baric RS, Go YY. Saracatinib Inhibits Middle East Respiratory Syndrome-Coronavirus Replication In Vitro. Viruses. 2018 05 24; 10(6). PMID: 29795047.
      Citations: 12     Fields:    Translation:HumansCells
    51. Kocher JF, Lindesmith LC, Debbink K, Beall A, Mallory ML, Yount BL, Graham RL, Huynh J, Gates JE, Donaldson EF, Baric RS. Bat Caliciviruses and Human Noroviruses Are Antigenically Similar and Have Overlapping Histo-Blood Group Antigen Binding Profiles. mBio. 2018 05 22; 9(3). PMID: 29789360.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    52. Agnihothram S, Menachery VD, Yount BL, Lindesmith LC, Scobey T, Whitmore A, Schäfer A, Heise MT, Baric RS. Development of a Broadly Accessible Venezuelan Equine Encephalitis Virus Replicon Particle Vaccine Platform. J Virol. 2018 06 01; 92(11). PMID: 29540599.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    53. Agostini ML, Andres EL, Sims AC, Graham RL, Sheahan TP, Lu X, Smith EC, Case JB, Feng JY, Jordan R, Ray AS, Cihlar T, Siegel D, Mackman RL, Clarke MO, Baric RS, Denison MR. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. mBio. 2018 03 06; 9(2). PMID: 29511076.
      Citations: 179     Fields:    Translation:AnimalsCells
    54. Sheahan TP, Baric RS. Is regulation preventing the development of therapeutics that may prevent future coronavirus pandemics? Future Virol. 2018 Mar; 13(3):143-146. PMID: 30546388.
      Citations:    
    55. Menachery VD, Schäfer A, Burnum-Johnson KE, Mitchell HD, Eisfeld AJ, Walters KB, Nicora CD, Purvine SO, Casey CP, Monroe ME, Weitz KK, Stratton KG, Webb-Robertson BM, Gralinski LE, Metz TO, Smith RD, Waters KM, Sims AC, Kawaoka Y, Baric RS. MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape. Proc Natl Acad Sci U S A. 2018 01 30; 115(5):E1012-E1021. PMID: 29339515.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    56. Douglas MG, Kocher JF, Scobey T, Baric RS, Cockrell AS. Adaptive evolution influences the infectious dose of MERS-CoV necessary to achieve severe respiratory disease. Virology. 2018 04; 517:98-107. PMID: 29277291.
      Citations: 12     Fields:    Translation:AnimalsCells
    57. Menachery VD, Gralinski LE, Mitchell HD, Dinnon KH, Leist SR, Yount BL, Graham RL, McAnarney ET, Stratton KG, Cockrell AS, Debbink K, Sims AC, Waters KM, Baric RS. Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis. mSphere. 2017 Nov-Dec; 2(6). PMID: 29152578.
      Citations: 25     Fields:    
    58. Peck KM, Scobey T, Swanstrom J, Jensen KL, Burch CL, Baric RS, Heise MT. Permissivity of Dipeptidyl Peptidase 4 Orthologs to Middle East Respiratory Syndrome Coronavirus Is Governed by Glycosylation and Other Complex Determinants. J Virol. 2017 10 01; 91(19). PMID: 28747502.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    59. Menachery VD, Mitchell HD, Cockrell AS, Gralinski LE, Yount BL, Graham RL, McAnarney ET, Douglas MG, Scobey T, Beall A, Dinnon K, Kocher JF, Hale AE, Stratton KG, Waters KM, Baric RS. MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis. mBio. 2017 08 22; 8(4). PMID: 28830941.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    60. Sheahan TP, Sims AC, Graham RL, Menachery VD, Gralinski LE, Case JB, Leist SR, Pyrc K, Feng JY, Trantcheva I, Bannister R, Park Y, Babusis D, Clarke MO, Mackman RL, Spahn JE, Palmiotti CA, Siegel D, Ray AS, Cihlar T, Jordan R, Denison MR, Baric RS. Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. Sci Transl Med. 2017 06 28; 9(396). PMID: 28659436.
      Citations: 208     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    61. Hou Y, Lin CM, Yokoyama M, Yount BL, Marthaler D, Douglas AL, Ghimire S, Qin Y, Baric RS, Saif LJ, Wang Q. Deletion of a 197-Amino-Acid Region in the N-Terminal Domain of Spike Protein Attenuates Porcine Epidemic Diarrhea Virus in Piglets. J Virol. 2017 07 15; 91(14). PMID: 28490591.
      Citations: 13     Fields:    Translation:AnimalsCells
    62. Gralinski LE, Menachery VD, Morgan AP, Totura AL, Beall A, Kocher J, Plante J, Harrison-Shostak DC, Schäfer A, Pardo-Manuel de Villena F, Ferris MT, Baric RS. Allelic Variation in the Toll-Like Receptor Adaptor Protein Ticam2 Contributes to SARS-Coronavirus Pathogenesis in Mice. G3 (Bethesda). 2017 06 07; 7(6):1653-1663. PMID: 28592648.
      Citations: 20     Fields:    Translation:AnimalsCells
    63. Anthony SJ, Gilardi K, Menachery VD, Goldstein T, Ssebide B, Mbabazi R, Navarrete-Macias I, Liang E, Wells H, Hicks A, Petrosov A, Byarugaba DK, Debbink K, Dinnon KH, Scobey T, Randell SH, Yount BL, Cranfield M, Johnson CK, Baric RS, Lipkin WI, Mazet JA. Further Evidence for Bats as the Evolutionary Source of Middle East Respiratory Syndrome Coronavirus. mBio. 2017 04 04; 8(2). PMID: 28377531.
      Citations: 52     Fields:    Translation:AnimalsCells
    64. Menachery VD, Graham RL, Baric RS. Jumping species-a mechanism for coronavirus persistence and survival. Curr Opin Virol. 2017 04; 23:1-7. PMID: 28214731.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    65. Gallichotte EN, Menachery VD, Yount BL, Widman DG, Dinnon KH, Hartman S, de Silva AM, Baric RS. Epitope Addition and Ablation via Manipulation of a Dengue Virus Serotype 1 Infectious Clone. mSphere. 2017 Jan-Feb; 2(1). PMID: 28251184.
      Citations: 7     Fields:    
    66. Schäfer A, Baric RS. Epigenetic Landscape during Coronavirus Infection. Pathogens. 2017 Feb 15; 6(1). PMID: 28212305.
      Citations:    
    67. Cockrell AS, Beall A, Yount B, Baric R. Efficient Reverse Genetic Systems for Rapid Genetic Manipulation of Emergent and Preemergent Infectious Coronaviruses. Methods Mol Biol. 2017; 1602:59-81. PMID: 28508214.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    68. Cockrell AS, Baric RS. An effective DNA vaccine platform for Middle East respiratory syndrome coronavirus. Ann Transl Med. 2016 Dec; 4(24):499. PMID: 28149861.
      Citations:    
    69. Cockrell AS, Yount BL, Scobey T, Jensen K, Douglas M, Beall A, Tang XC, Marasco WA, Heise MT, Baric RS. A mouse model for MERS coronavirus-induced acute respiratory distress syndrome. Nat Microbiol. 2016 Nov 28; 2:16226. PMID: 27892925.
      Citations: 59     Fields:    Translation:AnimalsCells
    70. McDermott JE, Mitchell HD, Gralinski LE, Eisfeld AJ, Josset L, Bankhead A, Neumann G, Tilton SC, Schäfer A, Li C, Fan S, McWeeney S, Baric RS, Katze MG, Waters KM. The effect of inhibition of PP1 and TNFa signaling on pathogenesis of SARS coronavirus. BMC Syst Biol. 2016 Sep 23; 10(1):93. PMID: 27663205.
      Citations: 14     Fields:    
    71. Zhao J, Zhao J, Mangalam AK, Channappanavar R, Fett C, Meyerholz DK, Agnihothram S, Baric RS, David CS, Perlman S. Airway Memory CD4(+) T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses. Immunity. 2016 06 21; 44(6):1379-91. PMID: 27287409.
      Citations: 55     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    72. Nakayasu ES, Nicora CD, Sims AC, Burnum-Johnson KE, Kim YM, Kyle JE, Matzke MM, Shukla AK, Chu RK, Schepmoes AA, Jacobs JM, Baric RS, Webb-Robertson BJ, Smith RD, Metz TO. MPLEx: a Robust and Universal Protocol for Single-Sample Integrative Proteomic, Metabolomic, and Lipidomic Analyses. mSystems. 2016 May-Jun; 1(3). PMID: 27822525.
      Citations:    
    73. Menachery VD, Yount BL, Debbink K, Agnihothram S, Gralinski LE, Plante JA, Graham RL, Scobey T, Ge XY, Donaldson EF, Randell SH, Lanzavecchia A, Marasco WA, Shi ZL, Baric RS. Corrigendum: A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence. Nat Med. 2016 Apr; 22(4):446. PMID: 27050591.
      Citations: 1     Fields:    
    74. Thornbrough JM, Jha BK, Yount B, Goldstein SA, Li Y, Elliott R, Sims AC, Baric RS, Silverman RH, Weiss SR. Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation. mBio. 2016 Mar 29; 7(2):e00258. PMID: 27025250.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    75. Menachery VD, Yount BL, Sims AC, Debbink K, Agnihothram SS, Gralinski LE, Graham RL, Scobey T, Plante JA, Royal SR, Swanstrom J, Sheahan TP, Pickles RJ, Corti D, Randell SH, Lanzavecchia A, Marasco WA, Baric RS. SARS-like WIV1-CoV poised for human emergence. Proc Natl Acad Sci U S A. 2016 Mar 15; 113(11):3048-53. PMID: 26976607.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    76. Johnson RF, Bagci U, Keith L, Tang X, Mollura DJ, Zeitlin L, Qin J, Huzella L, Bartos CJ, Bohorova N, Bohorov O, Goodman C, Kim DH, Paulty MH, Velasco J, Whaley KJ, Johnson JC, Pettitt J, Ork BL, Solomon J, Oberlander N, Zhu Q, Sun J, Holbrook MR, Olinger GG, Baric RS, Hensley LE, Jahrling PB, Marasco WA. 3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012. Virology. 2016 03; 490:49-58. PMID: 26828465.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    77. Beall A, Yount B, Lin CM, Hou Y, Wang Q, Saif L, Baric R. Characterization of a Pathogenic Full-Length cDNA Clone and Transmission Model for Porcine Epidemic Diarrhea Virus Strain PC22A. mBio. 2016 Jan 05; 7(1):e01451-15. PMID: 26733065.
      Citations: 16     Fields:    Translation:AnimalsCells
    78. Menachery VD, Yount BL, Debbink K, Agnihothram S, Gralinski LE, Plante JA, Graham RL, Scobey T, Ge XY, Donaldson EF, Randell SH, Lanzavecchia A, Marasco WA, Shi ZL, Baric RS. A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence. Nat Med. 2015 Dec; 21(12):1508-13. PMID: 26552008.
      Citations: 123     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    79. Gralinski LE, Ferris MT, Aylor DL, Whitmore AC, Green R, Frieman MB, Deming D, Menachery VD, Miller DR, Buus RJ, Bell TA, Churchill GA, Threadgill DW, Katze MG, McMillan L, Valdar W, Heise MT, Pardo-Manuel de Villena F, Baric RS. Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross. PLoS Genet. 2015 Oct; 11(10):e1005504. PMID: 26452100.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    80. Totura AL, Baric RS. Reply to "Statins may decrease the Fatality Rate of MERS Infection". mBio. 2015 Sep 29; 6(5):e01303-15. PMID: 26419878.
      Citations: 3     Fields:    Translation:AnimalsCells
    81. Peck KM, Burch CL, Heise MT, Baric RS. Coronavirus Host Range Expansion and Middle East Respiratory Syndrome Coronavirus Emergence: Biochemical Mechanisms and Evolutionary Perspectives. Annu Rev Virol. 2015 Nov; 2(1):95-117. PMID: 26958908.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    82. Corti D, Zhao J, Pedotti M, Simonelli L, Agnihothram S, Fett C, Fernandez-Rodriguez B, Foglierini M, Agatic G, Vanzetta F, Gopal R, Langrish CJ, Barrett NA, Sallusto F, Baric RS, Varani L, Zambon M, Perlman S, Lanzavecchia A. Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10473-8. PMID: 26216974.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    83. Menachery VD, Gralinski LE, Baric RS, Ferris MT. New Metrics for Evaluating Viral Respiratory Pathogenesis. PLoS One. 2015; 10(6):e0131451. PMID: 26115403.
      Citations: 6     Fields:    Translation:AnimalsCells
    84. Yang Y, Liu C, Du L, Jiang S, Shi Z, Baric RS, Li F. Two Mutations Were Critical for Bat-to-Human Transmission of Middle East Respiratory Syndrome Coronavirus. J Virol. 2015 Sep; 89(17):9119-23. PMID: 26063432.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    85. Totura AL, Whitmore A, Agnihothram S, Schäfer A, Katze MG, Heise MT, Baric RS. Toll-Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection. mBio. 2015 May 26; 6(3):e00638-15. PMID: 26015500.
      Citations: 70     Fields:    Translation:AnimalsCells
    86. Huang X, Dong W, Milewska A, Golda A, Qi Y, Zhu QK, Marasco WA, Baric RS, Sims AC, Pyrc K, Li W, Sui J. Human Coronavirus HKU1 Spike Protein Uses O-Acetylated Sialic Acid as an Attachment Receptor Determinant and Employs Hemagglutinin-Esterase Protein as a Receptor-Destroying Enzyme. J Virol. 2015 Jul; 89(14):7202-13. PMID: 25926653.
      Citations: 41     Fields:    Translation:HumansCells
    87. Peck KM, Cockrell AS, Yount BL, Scobey T, Baric RS, Heise MT. Glycosylation of mouse DPP4 plays a role in inhibiting Middle East respiratory syndrome coronavirus infection. J Virol. 2015 Apr; 89(8):4696-9. PMID: 25653445.
      Citations: 21     Fields:    Translation:AnimalsCells
    88. Zhang R, Li Y, Cowley TJ, Steinbrenner AD, Phillips JM, Yount BL, Baric RS, Weiss SR. The nsp1, nsp13, and M proteins contribute to the hepatotropism of murine coronavirus JHM.WU. J Virol. 2015 Apr; 89(7):3598-609. PMID: 25589656.
      Citations: 13     Fields:    Translation:AnimalsCells
    89. Gralinski LE, Baric RS. Molecular pathology of emerging coronavirus infections. J Pathol. 2015 Jan; 235(2):185-95. PMID: 25270030.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    90. Selinger C, Tisoncik-Go J, Menachery VD, Agnihothram S, Law GL, Chang J, Kelly SM, Sova P, Baric RS, Katze MG. Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates. BMC Genomics. 2014 Dec 22; 15:1161. PMID: 25534508.
      Citations: 5     Fields:    Translation:HumansCells
    91. Aevermann BD, Pickett BE, Kumar S, Klem EB, Agnihothram S, Askovich PS, Bankhead A, Bolles M, Carter V, Chang J, Clauss TR, Dash P, Diercks AH, Eisfeld AJ, Ellis A, Fan S, Ferris MT, Gralinski LE, Green RR, Gritsenko MA, Hatta M, Heegel RA, Jacobs JM, Jeng S, Josset L, Kaiser SM, Kelly S, Law GL, Li C, Li J, Long C, Luna ML, Matzke M, McDermott J, Menachery V, Metz TO, Mitchell H, Monroe ME, Navarro G, Neumann G, Podyminogin RL, Purvine SO, Rosenberger CM, Sanders CJ, Schepmoes AA, Shukla AK, Sims A, Sova P, Tam VC, Tchitchek N, Thomas PG, Tilton SC, Totura A, Wang J, Webb-Robertson BJ, Wen J, Weiss JM, Yang F, Yount B, Zhang Q, McWeeney S, Smith RD, Waters KM, et al. A comprehensive collection of systems biology data characterizing the host response to viral infection. Sci Data. 2014; 1:140033. PMID: 25977790.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    92. Menachery VD, Debbink K, Baric RS. Coronavirus non-structural protein 16: evasion, attenuation, and possible treatments. Virus Res. 2014 Dec 19; 194:191-9. PMID: 25278144.
      Citations: 17     Fields:    Translation:HumansCells
    93. Sui J, Deming M, Rockx B, Liddington RC, Zhu QK, Baric RS, Marasco WA. Effects of human anti-spike protein receptor binding domain antibodies on severe acute respiratory syndrome coronavirus neutralization escape and fitness. J Virol. 2014 Dec; 88(23):13769-80. PMID: 25231316.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    94. Yang Y, Du L, Liu C, Wang L, Ma C, Tang J, Baric RS, Jiang S, Li F. Receptor usage and cell entry of bat coronavirus HKU4 provide insight into bat-to-human transmission of MERS coronavirus. Proc Natl Acad Sci U S A. 2014 Aug 26; 111(34):12516-21. PMID: 25114257.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    95. Deng X, Agnihothram S, Mielech AM, Nichols DB, Wilson MW, StJohn SE, Larsen SD, Mesecar AD, Lenschow DJ, Baric RS, Baker SC. A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses. J Virol. 2014 Oct; 88(20):11825-33. PMID: 25100850.
      Citations: 11     Fields:    Translation:AnimalsCells
    96. Josset L, Tchitchek N, Gralinski LE, Ferris MT, Eisfeld AJ, Green RR, Thomas MJ, Tisoncik-Go J, Schroth GP, Kawaoka Y, Manuel de Villena FP, Baric RS, Heise MT, Peng X, Katze MG. Annotation of long non-coding RNAs expressed in collaborative cross founder mice in response to respiratory virus infection reveals a new class of interferon-stimulated transcripts. RNA Biol. 2014; 11(7):875-90. PMID: 24922324.
      Citations: 31     Fields:    Translation:AnimalsCells
    97. Xiong H, Morrison J, Ferris MT, Gralinski LE, Whitmore AC, Green R, Thomas MJ, Tisoncik-Go J, Schroth GP, Pardo-Manuel de Villena F, Baric RS, Heise MT, Peng X, Katze MG. Genomic profiling of collaborative cross founder mice infected with respiratory viruses reveals novel transcripts and infection-related strain-specific gene and isoform expression. G3 (Bethesda). 2014 Jun 05; 4(8):1429-44. PMID: 24902603.
      Citations: 12     Fields:    Translation:AnimalsCells
    98. Menachery VD, Eisfeld AJ, Schäfer A, Josset L, Sims AC, Proll S, Fan S, Li C, Neumann G, Tilton SC, Chang J, Gralinski LE, Long C, Green R, Williams CM, Weiss J, Matzke MM, Webb-Robertson BJ, Schepmoes AA, Shukla AK, Metz TO, Smith RD, Waters KM, Katze MG, Kawaoka Y, Baric RS. Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses. mBio. 2014 May 20; 5(3):e01174-14. PMID: 24846384.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    99. Schäfer A, Baric RS, Ferris MT. Systems approaches to Coronavirus pathogenesis. Curr Opin Virol. 2014 Jun; 6:61-9. PMID: 24842079.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    100. Tang XC, Agnihothram SS, Jiao Y, Stanhope J, Graham RL, Peterson EC, Avnir Y, Tallarico AS, Sheehan J, Zhu Q, Baric RS, Marasco WA. Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution. Proc Natl Acad Sci U S A. 2014 May 13; 111(19):E2018-26. PMID: 24778221.
      Citations: 78     Fields:    Translation:HumansAnimalsCells
    101. Agnihothram S, Yount BL, Donaldson EF, Huynh J, Menachery VD, Gralinski LE, Graham RL, Becker MM, Tomar S, Scobey TD, Osswald HL, Whitmore A, Gopal R, Ghosh AK, Mesecar A, Zambon M, Heise M, Denison MR, Baric RS. A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant. mBio. 2014 Mar 25; 5(2):e00047-14. PMID: 24667706.
      Citations: 22     Fields:    Translation:AnimalsCells
    102. Zhao J, Li K, Wohlford-Lenane C, Agnihothram SS, Fett C, Zhao J, Gale MJ, Baric RS, Enjuanes L, Gallagher T, McCray PB, Perlman S. Rapid generation of a mouse model for Middle East respiratory syndrome. Proc Natl Acad Sci U S A. 2014 Apr 01; 111(13):4970-5. PMID: 24599590.
      Citations: 145     Fields:    Translation:HumansAnimalsCells
    103. Cockrell AS, Peck KM, Yount BL, Agnihothram SS, Scobey T, Curnes NR, Baric RS, Heise MT. Mouse dipeptidyl peptidase 4 is not a functional receptor for Middle East respiratory syndrome coronavirus infection. J Virol. 2014 May; 88(9):5195-9. PMID: 24574399.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    104. Menachery VD, Yount BL, Josset L, Gralinski LE, Scobey T, Agnihothram S, Katze MG, Baric RS. Attenuation and restoration of severe acute respiratory syndrome coronavirus mutant lacking 2'-o-methyltransferase activity. J Virol. 2014 Apr; 88(8):4251-64. PMID: 24478444.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    105. Agnihothram S, Gopal R, Yount BL, Donaldson EF, Menachery VD, Graham RL, Scobey TD, Gralinski LE, Denison MR, Zambon M, Baric RS. Evaluation of serologic and antigenic relationships between middle eastern respiratory syndrome coronavirus and other coronaviruses to develop vaccine platforms for the rapid response to emerging coronaviruses. J Infect Dis. 2014 Apr 01; 209(7):995-1006. PMID: 24253287.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    106. Graham RL, Donaldson EF, Baric RS. A decade after SARS: strategies for controlling emerging coronaviruses. Nat Rev Microbiol. 2013 Dec; 11(12):836-48. PMID: 24217413.
      Citations: 136     Fields:    Translation:HumansCells
    107. Scobey T, Yount BL, Sims AC, Donaldson EF, Agnihothram SS, Menachery VD, Graham RL, Swanstrom J, Bove PF, Kim JD, Grego S, Randell SH, Baric RS. Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus. Proc Natl Acad Sci U S A. 2013 Oct 01; 110(40):16157-62. PMID: 24043791.
      Citations: 86     Fields:    Translation:HumansCells
    108. Menachery VD, Baric RS. Bugs in the system. Immunol Rev. 2013 Sep; 255(1):256-74. PMID: 23947361.
      Citations: 4     Fields:    Translation:HumansAnimals
    109. Gralinski LE, Bankhead A, Jeng S, Menachery VD, Proll S, Belisle SE, Matzke M, Webb-Robertson BJ, Luna ML, Shukla AK, Ferris MT, Bolles M, Chang J, Aicher L, Waters KM, Smith RD, Metz TO, Law GL, Katze MG, McWeeney S, Baric RS. Mechanisms of severe acute respiratory syndrome coronavirus-induced acute lung injury. mBio. 2013 Aug 06; 4(4). PMID: 23919993.
      Citations: 68     Fields:    Translation:AnimalsCells
    110. Chen Y, Rajashankar KR, Yang Y, Agnihothram SS, Liu C, Lin YL, Baric RS, Li F. Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus. J Virol. 2013 Oct; 87(19):10777-83. PMID: 23903833.
      Citations: 33     Fields:    Translation:HumansCells
    111. Mitchell HD, Eisfeld AJ, Sims AC, McDermott JE, Matzke MM, Webb-Robertson BJ, Tilton SC, Tchitchek N, Josset L, Li C, Ellis AL, Chang JH, Heegel RA, Luna ML, Schepmoes AA, Shukla AK, Metz TO, Neumann G, Benecke AG, Smith RD, Baric RS, Kawaoka Y, Katze MG, Waters KM. A network integration approach to predict conserved regulators related to pathogenicity of influenza and SARS-CoV respiratory viruses. PLoS One. 2013; 8(7):e69374. PMID: 23935999.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    112. de Groot RJ, Baker SC, Baric RS, Brown CS, Drosten C, Enjuanes L, Fouchier RA, Galiano M, Gorbalenya AE, Memish ZA, Perlman S, Poon LL, Snijder EJ, Stephens GM, Woo PC, Zaki AM, Zambon M, Ziebuhr J. Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group. J Virol. 2013 Jul; 87(14):7790-2. PMID: 23678167.
      Citations: 266     Fields:    Translation:HumansCells
    113. Josset L, Menachery VD, Gralinski LE, Agnihothram S, Sova P, Carter VS, Yount BL, Graham RL, Baric RS, Katze MG. Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus. mBio. 2013 Apr 30; 4(3):e00165-13. PMID: 23631916.
      Citations: 78     Fields:    Translation:HumansCells
    114. Chan RW, Chan MC, Agnihothram S, Chan LL, Kuok DI, Fong JH, Guan Y, Poon LL, Baric RS, Nicholls JM, Peiris JS. Tropism of and innate immune responses to the novel human betacoronavirus lineage C virus in human ex vivo respiratory organ cultures. J Virol. 2013 Jun; 87(12):6604-14. PMID: 23552422.
      Citations: 63     Fields:    Translation:HumansCells
    115. Sims AC, Tilton SC, Menachery VD, Gralinski LE, Schäfer A, Matzke MM, Webb-Robertson BJ, Chang J, Luna ML, Long CE, Shukla AK, Bankhead AR, Burkett SE, Zornetzer G, Tseng CT, Metz TO, Pickles R, McWeeney S, Smith RD, Katze MG, Waters KM, Baric RS. Release of severe acute respiratory syndrome coronavirus nuclear import block enhances host transcription in human lung cells. J Virol. 2013 Apr; 87(7):3885-902. PMID: 23365422.
      Citations: 38     Fields:    Translation:HumansCells
    116. Plant EP, Sims AC, Baric RS, Dinman JD, Taylor DR. Altering SARS coronavirus frameshift efficiency affects genomic and subgenomic RNA production. Viruses. 2013 Jan 18; 5(1):279-94. PMID: 23334702.
      Citations: 13     Fields:    Translation:HumansCells
    117. Ishimaru D, Plant EP, Sims AC, Yount BL, Roth BM, Eldho NV, Pérez-Alvarado GC, Armbruster DW, Baric RS, Dinman JD, Taylor DR, Hennig M. RNA dimerization plays a role in ribosomal frameshifting of the SARS coronavirus. Nucleic Acids Res. 2013 Feb 01; 41(4):2594-608. PMID: 23275571.
      Citations: 12     Fields:    Translation:Cells
    118. Graham RL, Becker MM, Eckerle LD, Bolles M, Denison MR, Baric RS. A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease. Nat Med. 2012 Dec; 18(12):1820-6. PMID: 23142821.
      Citations: 67     Fields:    Translation:AnimalsCells
    119. Anderson LJ, Baric RS. Emerging human coronaviruses--disease potential and preparedness. N Engl J Med. 2012 Nov 08; 367(19):1850-2. PMID: 23075144.
      Citations: 12     Fields:    Translation:HumansCells
    120. Huynh J, Li S, Yount B, Smith A, Sturges L, Olsen JC, Nagel J, Johnson JB, Agnihothram S, Gates JE, Frieman MB, Baric RS, Donaldson EF. Evidence supporting a zoonotic origin of human coronavirus strain NL63. J Virol. 2012 Dec; 86(23):12816-25. PMID: 22993147.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    121. Rani M, Bolles M, Donaldson EF, Van Blarcom T, Baric R, Iverson B, Georgiou G. Increased antibody affinity confers broad in vitro protection against escape mutants of severe acute respiratory syndrome coronavirus. J Virol. 2012 Sep; 86(17):9113-21. PMID: 22696652.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    122. Totura AL, Baric RS. SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon. Curr Opin Virol. 2012 Jun; 2(3):264-75. PMID: 22572391.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    123. Varshney B, Agnihothram S, Agnihotram S, Tan YJ, Baric R, Lal SK. SARS coronavirus 3b accessory protein modulates transcriptional activity of RUNX1b. PLoS One. 2012; 7(1):e29542. PMID: 22253733.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    124. Frieman M, Basu D, Matthews K, Taylor J, Jones G, Pickles R, Baric R, Engel DA. Yeast based small molecule screen for inhibitors of SARS-CoV. PLoS One. 2011; 6(12):e28479. PMID: 22164298.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    125. Bolles M, Donaldson E, Baric R. SARS-CoV and emergent coronaviruses: viral determinants of interspecies transmission. Curr Opin Virol. 2011 Dec; 1(6):624-34. PMID: 22180768.
      Citations: 33     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    126. Peng X, Gralinski L, Ferris MT, Frieman MB, Thomas MJ, Proll S, Korth MJ, Tisoncik JR, Heise M, Luo S, Schroth GP, Tumpey TM, Li C, Kawaoka Y, Baric RS, Katze MG. Integrative deep sequencing of the mouse lung transcriptome reveals differential expression of diverse classes of small RNAs in response to respiratory virus infection. mBio. 2011; 2(6). PMID: 22086488.
      Citations: 35     Fields:    Translation:AnimalsCells
    127. Frieman M, Yount B, Agnihothram S, Page C, Donaldson E, Roberts A, Vogel L, Woodruff B, Scorpio D, Subbarao K, Baric RS. Molecular determinants of severe acute respiratory syndrome coronavirus pathogenesis and virulence in young and aged mouse models of human disease. J Virol. 2012 Jan; 86(2):884-97. PMID: 22072787.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    128. Bolles M, Deming D, Long K, Agnihothram S, Whitmore A, Ferris M, Funkhouser W, Gralinski L, Totura A, Heise M, Baric RS. A double-inactivated severe acute respiratory syndrome coronavirus vaccine provides incomplete protection in mice and induces increased eosinophilic proinflammatory pulmonary response upon challenge. J Virol. 2011 Dec; 85(23):12201-15. PMID: 21937658.
      Citations: 85     Fields:    Translation:AnimalsCellsPHPublic Health
    129. Rockx B, Feldmann F, Brining D, Gardner D, LaCasse R, Kercher L, Long D, Rosenke R, Virtaneva K, Sturdevant DE, Porcella SF, Mattoon J, Parnell M, Baric RS, Feldmann H. Comparative pathogenesis of three human and zoonotic SARS-CoV strains in cynomolgus macaques. PLoS One. 2011 Apr 20; 6(4):e18558. PMID: 21533129.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    130. Denison MR, Graham RL, Donaldson EF, Eckerle LD, Baric RS. Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity. RNA Biol. 2011 Mar-Apr; 8(2):270-9. PMID: 21593585.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    131. te Velthuis AJ, van den Worm SH, Sims AC, Baric RS, Snijder EJ, van Hemert MJ. Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture. PLoS Pathog. 2010 Nov 04; 6(11):e1001176. PMID: 21079686.
      Citations: 77     Fields:    Translation:AnimalsCells
    132. Sheahan T, Whitmore A, Long K, Ferris M, Rockx B, Funkhouser W, Donaldson E, Gralinski L, Collier M, Heise M, Davis N, Johnston R, Baric RS. Successful vaccination strategies that protect aged mice from lethal challenge from influenza virus and heterologous severe acute respiratory syndrome coronavirus. J Virol. 2011 Jan; 85(1):217-30. PMID: 20980507.
      Citations: 32     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    133. Peng X, Gralinski L, Armour CD, Ferris MT, Thomas MJ, Proll S, Bradel-Tretheway BG, Korth MJ, Castle JC, Biery MC, Bouzek HK, Haynor DR, Frieman MB, Heise M, Raymond CK, Baric RS, Katze MG. Unique signatures of long noncoding RNA expression in response to virus infection and altered innate immune signaling. mBio. 2010 Oct 26; 1(5). PMID: 20978541.
      Citations: 94     Fields:    Translation:AnimalsCells
    134. Pyrc K, Sims AC, Dijkman R, Jebbink M, Long C, Deming D, Donaldson E, Vabret A, Baric R, van der Hoek L, Pickles R. Culturing the unculturable: human coronavirus HKU1 infects, replicates, and produces progeny virions in human ciliated airway epithelial cell cultures. J Virol. 2010 Nov; 84(21):11255-63. PMID: 20719951.
      Citations: 43     Fields:    Translation:HumansCells
    135. Zornetzer GA, Frieman MB, Rosenzweig E, Korth MJ, Page C, Baric RS, Katze MG. Transcriptomic analysis reveals a mechanism for a prefibrotic phenotype in STAT1 knockout mice during severe acute respiratory syndrome coronavirus infection. J Virol. 2010 Nov; 84(21):11297-309. PMID: 20702617.
      Citations: 19     Fields:    Translation:AnimalsCells
    136. Eckerle LD, Becker MM, Halpin RA, Li K, Venter E, Lu X, Scherbakova S, Graham RL, Baric RS, Stockwell TB, Spiro DJ, Denison MR. Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing. PLoS Pathog. 2010 May 06; 6(5):e1000896. PMID: 20463816.
      Citations: 85     Fields:    Translation:AnimalsCells
    137. Frieman MB, Chen J, Morrison TE, Whitmore A, Funkhouser W, Ward JM, Lamirande EW, Roberts A, Heise M, Subbarao K, Baric RS. SARS-CoV pathogenesis is regulated by a STAT1 dependent but a type I, II and III interferon receptor independent mechanism. PLoS Pathog. 2010 Apr 08; 6(4):e1000849. PMID: 20386712.
      Citations: 51     Fields:    Translation:AnimalsCells
    138. Rockx B, Donaldson E, Frieman M, Sheahan T, Corti D, Lanzavecchia A, Baric RS. Escape from human monoclonal antibody neutralization affects in vitro and in vivo fitness of severe acute respiratory syndrome coronavirus. J Infect Dis. 2010 Mar 15; 201(6):946-55. PMID: 20144042.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    139. Graham RL, Baric RS. Recombination, reservoirs, and the modular spike: mechanisms of coronavirus cross-species transmission. J Virol. 2010 Apr; 84(7):3134-46. PMID: 19906932.
      Citations: 129     Fields:    Translation:HumansAnimalsCells
    140. Freundt EC, Yu L, Goldsmith CS, Welsh S, Cheng A, Yount B, Liu W, Frieman MB, Buchholz UJ, Screaton GR, Lippincott-Schwartz J, Zaki SR, Xu XN, Baric RS, Subbarao K, Lenardo MJ. The open reading frame 3a protein of severe acute respiratory syndrome-associated coronavirus promotes membrane rearrangement and cell death. J Virol. 2010 Jan; 84(2):1097-109. PMID: 19889773.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    141. Day CW, Baric R, Cai SX, Frieman M, Kumaki Y, Morrey JD, Smee DF, Barnard DL. A new mouse-adapted strain of SARS-CoV as a lethal model for evaluating antiviral agents in vitro and in vivo. Virology. 2009 Dec 20; 395(2):210-22. PMID: 19853271.
      Citations: 40     Fields:    Translation:AnimalsCells
    142. Rockx B, Baas T, Zornetzer GA, Haagmans B, Sheahan T, Frieman M, Dyer MD, Teal TH, Proll S, van den Brand J, Baric R, Katze MG. Early upregulation of acute respiratory distress syndrome-associated cytokines promotes lethal disease in an aged-mouse model of severe acute respiratory syndrome coronavirus infection. J Virol. 2009 Jul; 83(14):7062-74. PMID: 19420084.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    143. Frieman M, Ratia K, Johnston RE, Mesecar AD, Baric RS. Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-kappaB signaling. J Virol. 2009 Jul; 83(13):6689-705. PMID: 19369340.
      Citations: 79     Fields:    Translation:HumansCells
    144. Liao HI, Olson CA, Hwang S, Deng H, Wong E, Baric RS, Roberts RW, Sun R. mRNA display design of fibronectin-based intrabodies that detect and inhibit severe acute respiratory syndrome coronavirus nucleocapsid protein. J Biol Chem. 2009 Jun 26; 284(26):17512-20. PMID: 19364769.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    145. Miknis ZJ, Donaldson EF, Umland TC, Rimmer RA, Baric RS, Schultz LW. Severe acute respiratory syndrome coronavirus nsp9 dimerization is essential for efficient viral growth. J Virol. 2009 Apr; 83(7):3007-18. PMID: 19153232.
      Citations: 12     Fields:    Translation:Cells
    146. Sheahan T, Morrison TE, Funkhouser W, Uematsu S, Akira S, Baric RS, Heise MT. MyD88 is required for protection from lethal infection with a mouse-adapted SARS-CoV. PLoS Pathog. 2008 Dec; 4(12):e1000240. PMID: 19079579.
      Citations: 66     Fields:    Translation:AnimalsCells
    147. Basu D, Walkiewicz MP, Frieman M, Baric RS, Auble DT, Engel DA. Novel influenza virus NS1 antagonists block replication and restore innate immune function. J Virol. 2009 Feb; 83(4):1881-91. PMID: 19052087.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    148. Frieman M, Baric R. Mechanisms of severe acute respiratory syndrome pathogenesis and innate immunomodulation. Microbiol Mol Biol Rev. 2008 Dec; 72(4):672-85, Table of Contents. PMID: 19052324.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    149. Becker MM, Graham RL, Donaldson EF, Rockx B, Sims AC, Sheahan T, Pickles RJ, Corti D, Johnston RE, Baric RS, Denison MR. Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice. Proc Natl Acad Sci U S A. 2008 Dec 16; 105(50):19944-9. PMID: 19036930.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    150. Donaldson EF, Yount B, Sims AC, Burkett S, Pickles RJ, Baric RS. Systematic assembly of a full-length infectious clone of human coronavirus NL63. J Virol. 2008 Dec; 82(23):11948-57. PMID: 18818320.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    151. Sheahan T, Rockx B, Donaldson E, Corti D, Baric R. Pathways of cross-species transmission of synthetically reconstructed zoonotic severe acute respiratory syndrome coronavirus. J Virol. 2008 Sep; 82(17):8721-32. PMID: 18579604.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    152. Lamirande EW, DeDiego ML, Roberts A, Jackson JP, Alvarez E, Sheahan T, Shieh WJ, Zaki SR, Baric R, Enjuanes L, Subbarao K. A live attenuated severe acute respiratory syndrome coronavirus is immunogenic and efficacious in golden Syrian hamsters. J Virol. 2008 Aug; 82(15):7721-4. PMID: 18463152.
      Citations: 33     Fields:    Translation:AnimalsCells
    153. Sparks JS, Donaldson EF, Lu X, Baric RS, Denison MR. A novel mutation in murine hepatitis virus nsp5, the viral 3C-like proteinase, causes temperature-sensitive defects in viral growth and protein processing. J Virol. 2008 Jun; 82(12):5999-6008. PMID: 18385240.
      Citations: 9     Fields:    Translation:AnimalsCells
    154. Pacciarini F, Ghezzi S, Canducci F, Sims A, Sampaolo M, Ferioli E, Clementi M, Poli G, Conaldi PG, Baric R, Vicenzi E. Persistent replication of severe acute respiratory syndrome coronavirus in human tubular kidney cells selects for adaptive mutations in the membrane protein. J Virol. 2008 Jun; 82(11):5137-44. PMID: 18367528.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    155. Rockx B, Corti D, Donaldson E, Sheahan T, Stadler K, Lanzavecchia A, Baric R. Structural basis for potent cross-neutralizing human monoclonal antibody protection against lethal human and zoonotic severe acute respiratory syndrome coronavirus challenge. J Virol. 2008 Apr; 82(7):3220-35. PMID: 18199635.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    156. Donaldson EF, Sims AC, Baric RS. Systematic assembly and genetic manipulation of the mouse hepatitis virus A59 genome. Methods Mol Biol. 2008; 454:293-315. PMID: 19057869.
      Citations: 2     Fields:    Translation:AnimalsCells
    157. Sheahan T, Rockx B, Donaldson E, Sims A, Pickles R, Corti D, Baric R. Mechanisms of zoonotic severe acute respiratory syndrome coronavirus host range expansion in human airway epithelium. J Virol. 2008 Mar; 82(5):2274-85. PMID: 18094188.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    158. McRoy WC, Baric RS. Amino acid substitutions in the S2 subunit of mouse hepatitis virus variant V51 encode determinants of host range expansion. J Virol. 2008 Feb; 82(3):1414-24. PMID: 18032498.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    159. Wathelet MG, Orr M, Frieman MB, Baric RS. Severe acute respiratory syndrome coronavirus evades antiviral signaling: role of nsp1 and rational design of an attenuated strain. J Virol. 2007 Nov; 81(21):11620-33. PMID: 17715225.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
    160. Deming DJ, Graham RL, Denison MR, Baric RS. Processing of open reading frame 1a replicase proteins nsp7 to nsp10 in murine hepatitis virus strain A59 replication. J Virol. 2007 Oct; 81(19):10280-91. PMID: 17634238.
      Citations: 23     Fields:    Translation:AnimalsCells
    161. Zhu Z, Chakraborti S, He Y, Roberts A, Sheahan T, Xiao X, Hensley LE, Prabakaran P, Rockx B, Sidorov IA, Corti D, Vogel L, Feng Y, Kim JO, Wang LF, Baric R, Lanzavecchia A, Curtis KM, Nabel GJ, Subbarao K, Jiang S, Dimitrov DS. Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):12123-8. PMID: 17620608.
      Citations: 76     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    162. Frieman M, Yount B, Heise M, Kopecky-Bromberg SA, Palese P, Baric RS. Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane. J Virol. 2007 Sep; 81(18):9812-24. PMID: 17596301.
      Citations: 125     Fields:    Translation:HumansAnimalsCells
    163. von Brunn A, Teepe C, Simpson JC, Pepperkok R, Friedel CC, Zimmer R, Roberts R, Baric R, Haas J. Analysis of intraviral protein-protein interactions of the SARS coronavirus ORFeome. PLoS One. 2007 May 23; 2(5):e459. PMID: 17520018.
      Citations: 62     Fields:    Translation:Cells
    164. Rockx B, Sheahan T, Donaldson E, Harkema J, Sims A, Heise M, Pickles R, Cameron M, Kelvin D, Baric R. Synthetic reconstruction of zoonotic and early human severe acute respiratory syndrome coronavirus isolates that produce fatal disease in aged mice. J Virol. 2007 Jul; 81(14):7410-23. PMID: 17507479.
      Citations: 34     Fields:    Translation:AnimalsCells
    165. Roberts A, Lamirande EW, Vogel L, Jackson JP, Paddock CD, Guarner J, Zaki SR, Sheahan T, Baric R, Subbarao K. Animal models and vaccines for SARS-CoV infection. Virus Res. 2008 Apr; 133(1):20-32. PMID: 17499378.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    166. Baric RS. SARS-CoV: lessons for global health. Virus Res. 2008 Apr; 133(1):1-3. PMID: 17467837.
      Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
    167. Frieman M, Heise M, Baric R. SARS coronavirus and innate immunity. Virus Res. 2008 Apr; 133(1):101-12. PMID: 17451827.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    168. Donaldson EF, Graham RL, Sims AC, Denison MR, Baric RS. Analysis of murine hepatitis virus strain A59 temperature-sensitive mutant TS-LA6 suggests that nsp10 plays a critical role in polyprotein processing. J Virol. 2007 Jul; 81(13):7086-98. PMID: 17428870.
      Citations: 21     Fields:    Translation:AnimalsCells
    169. Enjuanes L, Dediego ML, Alvarez E, Deming D, Sheahan T, Baric R. Vaccines to prevent severe acute respiratory syndrome coronavirus-induced disease. Virus Res. 2008 Apr; 133(1):45-62. PMID: 17416434.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    170. Donaldson EF, Sims AC, Graham RL, Denison MR, Baric RS. Murine hepatitis virus replicase protein nsp10 is a critical regulator of viral RNA synthesis. J Virol. 2007 Jun; 81(12):6356-68. PMID: 17392363.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    171. Roberts A, Deming D, Paddock CD, Cheng A, Yount B, Vogel L, Herman BD, Sheahan T, Heise M, Genrich GL, Zaki SR, Baric R, Subbarao K. A mouse-adapted SARS-coronavirus causes disease and mortality in BALB/c mice. PLoS Pathog. 2007 Jan; 3(1):e5. PMID: 17222058.
      Citations: 151     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    172. Deming D, Sheahan T, Heise M, Yount B, Davis N, Sims A, Suthar M, Harkema J, Whitmore A, Pickles R, West A, Donaldson E, Curtis K, Johnston R, Baric R. Vaccine efficacy in senescent mice challenged with recombinant SARS-CoV bearing epidemic and zoonotic spike variants. PLoS Med. 2006 Dec; 3(12):e525. PMID: 17194199.
      Citations: 68     Fields:    Translation:AnimalsCellsPHPublic Health
    173. Kopecky-Bromberg SA, Martínez-Sobrido L, Frieman M, Baric RA, Palese P. Severe acute respiratory syndrome coronavirus open reading frame (ORF) 3b, ORF 6, and nucleocapsid proteins function as interferon antagonists. J Virol. 2007 Jan; 81(2):548-57. PMID: 17108024.
      Citations: 171     Fields:    Translation:HumansCells
    174. Yount B, Roberts RS, Lindesmith L, Baric RS. Rewiring the severe acute respiratory syndrome coronavirus (SARS-CoV) transcription circuit: engineering a recombination-resistant genome. Proc Natl Acad Sci U S A. 2006 Aug 15; 103(33):12546-51. PMID: 16891412.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    175. Lawler JV, Endy TP, Hensley LE, Garrison A, Fritz EA, Lesar M, Baric RS, Kulesh DA, Norwood DA, Wasieloski LP, Ulrich MP, Slezak TR, Vitalis E, Huggins JW, Jahrling PB, Paragas J. Cynomolgus macaque as an animal model for severe acute respiratory syndrome. PLoS Med. 2006 May; 3(5):e149. PMID: 16605302.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    176. Frieman MB, Yount B, Sims AC, Deming DJ, Morrison TE, Sparks J, Denison M, Heise M, Baric RS. SARS coronavirus accessory ORFs encode luxury functions. Adv Exp Med Biol. 2006; 581:149-52. PMID: 17037522.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    177. McRoy WC, Baric RS. Spike gene determinants of mouse hepatitis virus host range expansion. Adv Exp Med Biol. 2006; 581:301-4. PMID: 17037548.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    178. Sims AC, Yount B, Burkett SE, Baric RS, Pickles RJ. SARS CoV replication and pathogenesis in human airway epithelial cultures. Adv Exp Med Biol. 2006; 581:535-8. PMID: 17037593.
      Citations: 4     Fields:    Translation:HumansCells
    179. Sheahan T, Deming D, Donaldson E, Pickles R, Baric R. Resurrection of an "extinct" SARS-CoV isolate GD03 from late 2003. Adv Exp Med Biol. 2006; 581:547-50. PMID: 17037596.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    180. Baric RS, Sheahan T, Deming D, Donaldson E, Yount B, Sims AC, Roberts RS, Frieman M, Rockx B. SARS coronavirus vaccine development. Adv Exp Med Biol. 2006; 581:553-60. PMID: 17037597.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    181. Roberts RS, Yount BL, Sims AC, Baker S, Baric RS. Renilla luciferase as a reporter to assess SARS-CoV mRNA transcription regulation and efficacy of anti-SARS-CoV agents. Adv Exp Med Biol. 2006; 581:597-600. PMID: 17037604.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    182. Donaldson EF, Sims AC, Deming DJ, Baric RS. Mutational analysis of MHV-A59 replicase protein-nsp10. Adv Exp Med Biol. 2006; 581:61-6. PMID: 17037505.
      Citations: 1     Fields:    Translation:AnimalsCells
    183. Graham RL, Sims AC, Baric RS, Denison MR. The nsp2 proteins of mouse hepatitis virus and SARS coronavirus are dispensable for viral replication. Adv Exp Med Biol. 2006; 581:67-72. PMID: 17037506.
      Citations: 4     Fields:    Translation:AnimalsCells
    184. Deming DJ, Graham RL, Denison MR, Baric RS. MHV-A59 ORF1a replicase protein nsp7-nsp10 processing in replication. Adv Exp Med Biol. 2006; 581:101-4. PMID: 17037513.
      Citations: 2     Fields:    Translation:AnimalsCells
    185. Pekosz A, Schaecher SR, Diamond MS, Fremont DH, Sims AC, Baric RS. Structure, expression, and intracellular localization of the SARS-CoV accessory proteins 7a and 7b. Adv Exp Med Biol. 2006; 581:115-20. PMID: 17037516.
      Citations: 6     Fields:    Translation:AnimalsCells
    186. Johnson RF, Feng M, Liu P, Millership JJ, Yount B, Baric RS, Leibowitz JL. Effect of mutations in the mouse hepatitis virus 3'(+)42 protein binding element on RNA replication. J Virol. 2005 Dec; 79(23):14570-85. PMID: 16282457.
      Citations: 17     Fields:    Translation:AnimalsCells
    187. Yount B, Roberts RS, Sims AC, Deming D, Frieman MB, Sparks J, Denison MR, Davis N, Baric RS. Severe acute respiratory syndrome coronavirus group-specific open reading frames encode nonessential functions for replication in cell cultures and mice. J Virol. 2005 Dec; 79(23):14909-22. PMID: 16282490.
      Citations: 94     Fields:    Translation:AnimalsCells
    188. Sims AC, Baric RS, Yount B, Burkett SE, Collins PL, Pickles RJ. Severe acute respiratory syndrome coronavirus infection of human ciliated airway epithelia: role of ciliated cells in viral spread in the conducting airways of the lungs. J Virol. 2005 Dec; 79(24):15511-24. PMID: 16306622.
      Citations: 96     Fields:    Translation:HumansCells
    189. Graham RL, Sims AC, Brockway SM, Baric RS, Denison MR. The nsp2 replicase proteins of murine hepatitis virus and severe acute respiratory syndrome coronavirus are dispensable for viral replication. J Virol. 2005 Nov; 79(21):13399-411. PMID: 16227261.
      Citations: 59     Fields:    Translation:AnimalsCells
    190. Baric RS, Sims AC. Humanized mice develop coronavirus respiratory disease. Proc Natl Acad Sci U S A. 2005 Jun 07; 102(23):8073-4. PMID: 15928078.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    191. Sperry SM, Kazi L, Graham RL, Baric RS, Weiss SR, Denison MR. Single-amino-acid substitutions in open reading frame (ORF) 1b-nsp14 and ORF 2a proteins of the coronavirus mouse hepatitis virus are attenuating in mice. J Virol. 2005 Mar; 79(6):3391-400. PMID: 15731233.
      Citations: 43     Fields:    Translation:AnimalsCells
    192. Brian DA, Baric RS. Coronavirus genome structure and replication. Curr Top Microbiol Immunol. 2005; 287:1-30. PMID: 15609507.
      Citations: 132     Fields:    Translation:HumansAnimalsCells
    193. Baric RS, Sims AC. Development of mouse hepatitis virus and SARS-CoV infectious cDNA constructs. Curr Top Microbiol Immunol. 2005; 287:229-52. PMID: 15609514.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    194. Denison MR, Yount B, Brockway SM, Graham RL, Sims AC, Lu X, Baric RS. Cleavage between replicase proteins p28 and p65 of mouse hepatitis virus is not required for virus replication. J Virol. 2004 Jun; 78(11):5957-65. PMID: 15140993.
      Citations: 27     Fields:    Translation:Cells
    195. Curtis KM, Yount B, Sims AC, Baric RS. Reverse genetic analysis of the transcription regulatory sequence of the coronavirus transmissible gastroenteritis virus. J Virol. 2004 Jun; 78(11):6061-6. PMID: 15141005.
      Citations: 4     Fields:    Translation:Cells
    196. Yount B, Curtis KM, Fritz EA, Hensley LE, Jahrling PB, Prentice E, Denison MR, Geisbert TW, Baric RS. Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12995-3000. PMID: 14569023.
      Citations: 127     Fields:    Translation:HumansAnimalsCells
    197. Yount B, Denison MR, Weiss SR, Baric RS. Systematic assembly of a full-length infectious cDNA of mouse hepatitis virus strain A59. J Virol. 2002 Nov; 76(21):11065-78. PMID: 12368349.
      Citations: 140     Fields:    Translation:AnimalsCells
    198. Curtis KM, Yount B, Baric RS. Heterologous gene expression from transmissible gastroenteritis virus replicon particles. J Virol. 2002 Feb; 76(3):1422-34. PMID: 11773416.
      Citations: 48     Fields:    Translation:AnimalsCells
    199. Baric RS, Curtis KM, Yount B. MHV subgenomic negative strand function. Adv Exp Med Biol. 2001; 494:459-65. PMID: 11774508.
      Citations: 2     Fields:    Translation:AnimalsCells
    200. Curtis KM, Yount B, Baric RS. A simple strategy to assemble infectious RNA and DNA clones. Adv Exp Med Biol. 2001; 494:475-81. PMID: 11774510.
      Citations: 1     Fields:    Translation:AnimalsCells
    201. Yount B, Curtis KM, Baric RS. Strategy for systematic assembly of large RNA and DNA genomes: transmissible gastroenteritis virus model. J Virol. 2000 Nov; 74(22):10600-11. PMID: 11044104.
      Citations: 87     Fields:    Translation:AnimalsCells
    202. Baric RS, Yount B. Subgenomic negative-strand RNA function during mouse hepatitis virus infection. J Virol. 2000 May; 74(9):4039-46. PMID: 10756015.
      Citations: 36     Fields:    Translation:AnimalsCells
    203. Alexander LK, Keene BW, Yount BL, Geratz JD, Small JD, Baric RS. ECG changes after rabbit coronavirus infection. J Electrocardiol. 1999 Jan; 32(1):21-32. PMID: 10037086.
      Citations: 6     Fields:    Translation:Animals
    204. Baric RS, Sullivan E, Hensley L, Yount B, Chen W. Persistent infection promotes cross-species transmissibility of mouse hepatitis virus. J Virol. 1999 Jan; 73(1):638-49. PMID: 9847369.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    205. Stalcup RP, Baric RS, Leibowitz JL. Genetic complementation among three panels of mouse hepatitis virus gene 1 mutants. Virology. 1998 Feb 01; 241(1):112-21. PMID: 9454722.
      Citations: 7     Fields:    Translation:AnimalsCells
    206. Chen W, Yount B, Hensley L, Baric RS. Receptor homologue scanning functions in the maintenance of MHV-A59 persistence in vitro. Adv Exp Med Biol. 1998; 440:743-50. PMID: 9782353.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    207. Hensley LE, Holmes KV, Beauchemin N, Baric RS. Virus-receptor interactions and interspecies transfer of a mouse hepatitis virus. Adv Exp Med Biol. 1998; 440:33-41. PMID: 9782262.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    208. Hensley LE, Baric RS. Human biliary glycoproteins function as receptors for interspecies transfer of mouse hepatitis virus. Adv Exp Med Biol. 1998; 440:43-52. PMID: 9782263.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    209. Baric RS, Yount B, Hensley L, Peel SA, Chen W. Episodic evolution mediates interspecies transfer of a murine coronavirus. J Virol. 1997 Mar; 71(3):1946-55. PMID: 9032326.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    210. Chen W, Madden VJ, Bagnell CR, Baric RS. Host-derived intracellular immunization against mouse hepatitis virus infection. Virology. 1997 Feb 17; 228(2):318-32. PMID: 9123839.
      Citations: 18     Fields:    Translation:AnimalsCells
    211. Chen W, Baric RS. Molecular anatomy of mouse hepatitis virus persistence: coevolution of increased host cell resistance and virus virulence. J Virol. 1996 Jun; 70(6):3947-60. PMID: 8648732.
      Citations: 42     Fields:    Translation:AnimalsCells
    212. Chen W, Baric RS. Function of a 5'-end genomic RNA mutation that evolves during persistent mouse hepatitis virus infection in vitro. J Virol. 1995 Dec; 69(12):7529-40. PMID: 7494259.
      Citations: 16     Fields:    Translation:AnimalsCells
    213. Baric RS, Schaad MC. Evidence that MHV subgenomic negative strands are functional templates. Adv Exp Med Biol. 1995; 380:491-7. PMID: 8830529.
      Citations:    Fields:    Translation:AnimalsCells
    214. Baric RS, Fu K, Chen W, Yount B. High recombination and mutation rates in mouse hepatitis virus suggest that coronaviruses may be potentially important emerging viruses. Adv Exp Med Biol. 1995; 380:571-6. PMID: 8830544.
      Citations: 6     Fields:    Translation:AnimalsCells
    215. Chen W, Baric RS. Evolution and persistence mechanisms of mouse hepatitis virus. Adv Exp Med Biol. 1995; 380:63-71. PMID: 8830548.
      Citations: 1     Fields:    Translation:AnimalsCells
    216. Alexander LK, Keene BW, Baric RS. Echocardiographic changes following rabbit coronavirus infection. Adv Exp Med Biol. 1995; 380:113-5. PMID: 8830464.
      Citations: 1     Fields:    Translation:Animals
    217. Schaad MC, Baric RS. Genetics of mouse hepatitis virus transcription: evidence that subgenomic negative strands are functional templates. J Virol. 1994 Dec; 68(12):8169-79. PMID: 7966608.
      Citations: 40     Fields:    Translation:AnimalsCells
    218. Fu K, Baric RS. Map locations of mouse hepatitis virus temperature-sensitive mutants: confirmation of variable rates of recombination. J Virol. 1994 Nov; 68(11):7458-66. PMID: 7933129.
      Citations: 21     Fields:    Translation:Cells
    219. Schaad MC, Baric RS. Evidence for new transcriptional units encoded at the 3' end of the mouse hepatitis virus genome. Virology. 1993 Sep; 196(1):190-8. PMID: 8395114.
      Citations: 12     Fields:    Translation:AnimalsCells
    220. Baker SC, Gao H, Baric RS. Altered proteolytic processing of the polymerase polyprotein in RNA(-) temperature sensitive mutants of murine coronavirus. Adv Exp Med Biol. 1993; 342:215-9. PMID: 8209733.
      Citations: 1     Fields:    Translation:Cells
    221. Hughes SA, Denison MR, Bonilla P, Leibowitz JL, Baric RS, Weiss SR. A newly identified MHV-A59 ORF1a polypeptide p65 is temperature sensitive in two RNA negative mutants. Adv Exp Med Biol. 1993; 342:221-6. PMID: 8209734.
      Citations: 1     Fields:    Translation:AnimalsCells
    222. Alexander LK, Keene BW, Small JD, Yount B, Baric RS. Electrocardiographic changes following rabbit coronavirus-induced myocarditis and dilated cardiomyopathy. Adv Exp Med Biol. 1993; 342:365-70. PMID: 8209755.
      Citations: 4     Fields:    Translation:Animals
    223. Schaad MC, Chen W, Peel SA, Baric RS. Studies into the mechanism for MHV transcription. Adv Exp Med Biol. 1993; 342:85-90. PMID: 8209776.
      Citations: 4     Fields:    Translation:Cells
    224. Alexander LK, Small JD, Edwards S, Baric RS. An experimental model for dilated cardiomyopathy after rabbit coronavirus infection. J Infect Dis. 1992 Nov; 166(5):978-85. PMID: 1328411.
      Citations: 10     Fields:    Translation:Animals
    225. Fu K, Baric RS. Evidence for variable rates of recombination in the MHV genome. Virology. 1992 Jul; 189(1):88-102. PMID: 1318616.
      Citations: 21     Fields:    Translation:Cells
    226. Edwards S, Small JD, Geratz JD, Alexander LK, Baric RS. An experimental model for myocarditis and congestive heart failure after rabbit coronavirus infection. J Infect Dis. 1992 Jan; 165(1):134-40. PMID: 1309370.
      Citations: 9     Fields:    Translation:Animals
    227. Schaad MC, Stohlman SA, Egbert J, Lum K, Fu K, Wei T, Baric RS. Genetics of mouse hepatitis virus transcription: identification of cistrons which may function in positive and negative strand RNA synthesis. Virology. 1990 Aug; 177(2):634-45. PMID: 2164727.
      Citations: 18     Fields:    Translation:AnimalsCells
    228. Baric RS, Fu K, Schaad MC, Stohlman SA. Establishing a genetic recombination map for murine coronavirus strain A59 complementation groups. Virology. 1990 Aug; 177(2):646-56. PMID: 2164728.
      Citations: 49     Fields:    Translation:AnimalsCells
    229. Baric RS, Schaad MC, Wei T, Fu KS, Lum K, Shieh C, Stohlman SA. Murine coronavirus temperature sensitive mutants. Adv Exp Med Biol. 1990; 276:349-56. PMID: 1966422.
      Citations: 3     Fields:    Translation:AnimalsCells
    230. Stohlman SA, Baric RS, Nelson GN, Soe LH, Welter LM, Deans RJ. Specific interaction between coronavirus leader RNA and nucleocapsid protein. J Virol. 1988 Nov; 62(11):4288-95. PMID: 2845141.
      Citations: 61     Fields:    Translation:Cells
    231. Baric RS, Nelson GW, Fleming JO, Deans RJ, Keck JG, Casteel N, Stohlman SA. Interactions between coronavirus nucleocapsid protein and viral RNAs: implications for viral transcription. J Virol. 1988 Nov; 62(11):4280-7. PMID: 2845140.
      Citations: 62     Fields:    Translation:Cells
    232. Baric RS, Shieh CK, Stohlman SA, Lai MM. Analysis of intracellular small RNAs of mouse hepatitis virus: evidence for discontinuous transcription. Virology. 1987 Feb; 156(2):342-54. PMID: 3027983.
      Citations: 22     Fields:    Translation:Cells
    233. Baric RS, Shieh CK, Stohlman SA, Lai MM. Studies into the mechanism of MHV transcription. Adv Exp Med Biol. 1987; 218:137-49. PMID: 2829521.
      Citations: 2     Fields:    Translation:Cells
    234. Lai MM, Baric RS, Makino S, Keck JG, Egbert J, Leibowitz JL, Stohlman SA. Recombination between nonsegmented RNA genomes of murine coronaviruses. J Virol. 1985 Nov; 56(2):449-56. PMID: 2997467.
      Citations: 56     Fields:    Translation:Cells
    235. Baric RS, Stohlman SA, Razavi MK, Lai MM. Characterization of leader-related small RNAs in coronavirus-infected cells: further evidence for leader-primed mechanism of transcription. Virus Res. 1985 Jul; 3(1):19-33. PMID: 2992183.
      Citations: 32     Fields:    Translation:AnimalsCells
    236. Lai MM, Baric RS, Brayton PR, Stohlman SA. Characterization of leader RNA sequences on the virion and mRNAs of mouse hepatitis virus, a cytoplasmic RNA virus. Proc Natl Acad Sci U S A. 1984 Jun; 81(12):3626-30. PMID: 6328522.
      Citations: 83     Fields:    Translation:Cells
    237. Lai MM, Baric RS, Brayton PR, Stohlman SA. Studies on the mechanism of RNA synthesis of a murine coronavirus. Adv Exp Med Biol. 1984; 173:187-200. PMID: 6331110.
      Citations: 1     Fields:    Translation:AnimalsCells
    238. Baric RS, Stohlman SA, Lai MM. Characterization of replicative intermediate RNA of mouse hepatitis virus: presence of leader RNA sequences on nascent chains. J Virol. 1983 Dec; 48(3):633-40. PMID: 6313963.
      Citations: 52     Fields:    Translation:AnimalsCells
    239. Lai MM, Patton CD, Baric RS, Stohlman SA. Presence of leader sequences in the mRNA of mouse hepatitis virus. J Virol. 1983 Jun; 46(3):1027-33. PMID: 6304334.
      Citations: 58     Fields:    Translation:Cells
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