SAM Domain and HD Domain-Containing Protein 1
"SAM Domain and HD Domain-Containing Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A host restriction triphosphorylhydrolase and dNTPase that contains an N-terminal STERILE ALPHA MOTIF and central, conserved ASPARTATE and HISTIDINE (HD) domain. It acts on single-stranded RNA, yielding deoxynucleosides and triphosphate, and functions in anti-viral defense through its dNTPase activity, reducing cellular dNTP levels below what is required for retroviral reverse transcription in DENDRITIC CELLS and MYELOID CELLS. It also has RIBONUCLEASE activity which blocks early replication of retroviruses such as HIV-1. Mutations in the SAMHD1 gene are associated with type 5 Aicardi-Goutieres syndrome (AGS5) and type 2 chilblain LUPUS (CHBL2).
Descriptor ID |
D000076106
|
MeSH Number(s) |
D08.811.277.040.725 D08.811.277.352.700.843
|
Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "SAM Domain and HD Domain-Containing Protein 1".
Below are MeSH descriptors whose meaning is more specific than "SAM Domain and HD Domain-Containing Protein 1".
This graph shows the total number of publications written about "SAM Domain and HD Domain-Containing Protein 1" by people in this website by year, and whether "SAM Domain and HD Domain-Containing Protein 1" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
---|
2012 | 0 | 1 | 1 |
2013 | 0 | 2 | 2 |
2014 | 0 | 1 | 1 |
2017 | 3 | 2 | 5 |
2018 | 4 | 2 | 6 |
2020 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "SAM Domain and HD Domain-Containing Protein 1" by people in Profiles.
-
Dysregulation of the mevalonate pathway during SARS-CoV-2 infection: An in silico study. J Med Virol. 2021 04; 93(4):2396-2405.
-
Host SAMHD1 protein restricts endogenous reverse transcription of HIV-1 in nondividing macrophages. Retrovirology. 2018 10 13; 15(1):69.
-
The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1. Proc Natl Acad Sci U S A. 2018 10 23; 115(43):E10022-E10031.
-
IL-15 regulates susceptibility of CD4+ T cells to HIV infection. Proc Natl Acad Sci U S A. 2018 10 09; 115(41):E9659-E9667.
-
Interplay of ancestral non-primate lentiviruses with the virus-restricting SAMHD1 proteins of their hosts. J Biol Chem. 2018 10 19; 293(42):16402-16412.
-
The aryl hydrocarbon receptor and interferon gamma generate antiviral states via transcriptional repression. Elife. 2018 08 22; 7.
-
Cyclin E2-CDK2 mediates SAMHD1 phosphorylation to abrogate its restriction of HBV replication in hepatoma cells. FEBS Lett. 2018 06; 592(11):1893-1904.
-
T cells with low CD2 levels express reduced restriction factors and are preferentially infected in therapy naïve chronic HIV-1 patients. J Int AIDS Soc. 2017 09 19; 20(1):21865.
-
Potential role of tyrosine kinase inhibitors during primary HIV-1 infection. Expert Rev Anti Infect Ther. 2017 05; 15(5):421-423.
-
SAMHD1 is active in cycling cells permissive to HIV-1 infection. Antiviral Res. 2017 06; 142:123-135.