Arachidonate 12-Lipoxygenase
"Arachidonate 12-Lipoxygenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the oxidation of arachidonic acid to yield 12-hydroperoxyarachidonate (12-HPETE) which is itself rapidly converted by a peroxidase to 12-hydroxy-5,8,10,14-eicosatetraenoate (12-HETE). The 12-hydroperoxides are preferentially formed in PLATELETS.
| Descriptor ID |
D001092
|
| MeSH Number(s) |
D08.811.682.690.416.583.500.060 D12.776.556.579.374.568.500.025
|
| Concept/Terms |
Arachidonate 12-Lipoxygenase- Arachidonate 12-Lipoxygenase
- 12-Lipoxygenase, Arachidonate
- Arachidonate 12 Lipoxygenase
- Arachidonic Acid 12-Lipoxygenase
- 12-Lipoxygenase, Arachidonic Acid
- Arachidonic Acid 12 Lipoxygenase
- 12-Lipoxygenase
- 12 Lipoxygenase
|
Below are MeSH descriptors whose meaning is more general than "Arachidonate 12-Lipoxygenase".
Below are MeSH descriptors whose meaning is more specific than "Arachidonate 12-Lipoxygenase".
This graph shows the total number of publications written about "Arachidonate 12-Lipoxygenase" by people in this website by year, and whether "Arachidonate 12-Lipoxygenase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Arachidonate 12-Lipoxygenase" by people in Profiles.
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Cutting Edge: Severe SARS-CoV-2 Infection in Humans Is Defined by a Shift in the Serum Lipidome, Resulting in Dysregulation of Eicosanoid Immune Mediators. J Immunol. 2021 01 15; 206(2):329-334.
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Transcriptomic and lipidomic profiling of eicosanoid/docosanoid signalling in affected and non-affected skin of human atopic dermatitis patients. Exp Dermatol. 2019 02; 28(2):177-189.
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Inhibition of Arachidonate 12/15-Lipoxygenase Improves a-Galactosidase Efficacy in iPSC-Derived Cardiomyocytes from Fabry Patients. Int J Mol Sci. 2018 May 16; 19(5).
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Investigation of calcium-dependent activity and conformational dynamics of zebra fish 12-lipoxygenase. Biochim Biophys Acta Gen Subj. 2017 Aug; 1861(8):2099-2111.