"Complement C1q" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subcomponent of complement C1, composed of six copies of three polypeptide chains (A, B, and C), each encoded by a separate gene (C1QA; C1QB; C1QC). This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY.
| Descriptor ID |
D015922
|
| MeSH Number(s) |
D12.776.124.486.274.050.270
|
| Concept/Terms |
Complement C1q- Complement C1q
- C1q, Complement
- Complement Component 1q
- Component 1q, Complement
- C1q Complement
- Complement, C1q
- Complement 1q
|
Below are MeSH descriptors whose meaning is more general than "Complement C1q".
Below are MeSH descriptors whose meaning is more specific than "Complement C1q".
This graph shows the total number of publications written about "Complement C1q" by people in this website by year, and whether "Complement C1q" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2017 | 2 | 1 | 3 |
| 2018 | 4 | 3 | 7 |
| 2019 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Complement C1q" by people in Profiles.
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Clinical Characteristics and Immune Injury Mechanisms in 71 Patients with COVID-19. mSphere. 2020 07 15; 5(4).
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Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion. J Vis Exp. 2019 06 15; (148).
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Anti-perlecan antibodies and acute humoral rejection in hypersensitized patients without forbidden HLA specificities after kidney transplantation. Transpl Immunol. 2019 02; 52:53-56.
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Complement Component C1q as Serum Biomarker to Detect Active Tuberculosis. Front Immunol. 2018; 9:2427.
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Active Human Complement Reduces the Zika Virus Load via Formation of the Membrane-Attack Complex. Front Immunol. 2018; 9:2177.
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The disappointing contribution of anti-human leukocyte antigen donor-specific antibodies characteristics for predicting allograft loss. Nephrol Dial Transplant. 2018 10 01; 33(10):1853-1863.
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Whole Exome Sequencing in Early-onset Systemic Lupus Erythematosus. J Rheumatol. 2018 12; 45(12):1671-1679.
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Prognostic Value of the Persistence of C1q-Binding Anti-HLA Antibodies in Acute Antibody-Mediated Rejection in Kidney Transplantation. Transplantation. 2018 04; 102(4):688-698.
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Zika virus infection elicits auto-antibodies to C1q. Sci Rep. 2018 01 30; 8(1):1882.
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[Hypocomplementemic urticarial vasculitis]. Rev Med Interne. 2018 Feb; 39(2):90-98.