Immunoglobulin Class Switching
"Immunoglobulin Class Switching" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing.
| Descriptor ID |
D017578
|
| MeSH Number(s) |
G05.344.401.501.450 G12.500.274.501.450
|
| Concept/Terms |
Immunoglobulin Class Switching- Immunoglobulin Class Switching
- Class Switching, Immunoglobulin
- Class Switchings, Immunoglobulin
- Immunoglobulin Class Switchings
- Switching, Immunoglobulin Class
- Switchings, Immunoglobulin Class
- Class Switching
- Class Switchings
- Switching, Class
- Switchings, Class
- Isotype Switching
- Isotype Switchings
- Switching, Isotype
- Switchings, Isotype
|
Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Class Switching".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Class Switching".
This graph shows the total number of publications written about "Immunoglobulin Class Switching" by people in this website by year, and whether "Immunoglobulin Class Switching" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 5 | 6 |
| 2018 | 0 | 3 | 3 |
| 2019 | 2 | 0 | 2 |
| 2021 | 1 | 4 | 5 |
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Below are the most recent publications written about "Immunoglobulin Class Switching" by people in Profiles.
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Humoral Immunity against SARS-CoV-2 and the Impact on COVID-19 Pathogenesis. Mol Cells. 2021 Jun 30; 44(6):392-400.
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Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2. Nature. 2021 08; 596(7872):417-422.
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Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues. Science. 2021 05 14; 372(6543):738-741.
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Durable SARS-CoV-2 B cell immunity after mild or severe disease. J Clin Invest. 2021 04 01; 131(7).
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Longitudinal antibody repertoire in "mild" versus "severe" COVID-19 patients reveals immune markers associated with disease severity and resolution. Sci Adv. 2021 03; 7(10).
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Sensitive detection of total anti-Spike antibodies and isotype switching in asymptomatic and symptomatic individuals with COVID-19. Cell Rep Med. 2021 02 16; 2(2):100193.
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Flagellin-expressing virus-like particles exhibit adjuvant effects on promoting IgG isotype-switched long-lasting antibody induction and protection of influenza vaccines in CD4-deficient mice. Vaccine. 2019 06 06; 37(26):3426-3434.
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Genetic polymorphisms in genes of class switch recombination and multiple myeloma risk and survival: an IMMEnSE study. Leuk Lymphoma. 2019 07; 60(7):1803-1811.
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Hypogammaglobulinemia with decreased class-switched B-cells and dysregulated T-follicular-helper cells in IPEX syndrome. Clin Immunol. 2018 12; 197:219-223.
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A human immune system mouse model with robust lymph node development. Nat Methods. 2018 08; 15(8):623-630.