2',5'-Oligoadenylate Synthetase
"2',5'-Oligoadenylate Synthetase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. These oligonucleotides activate an endoribonuclease (RNase L) which cleaves single-stranded RNA. Interferons can act as inducers of these reactions.
| Descriptor ID |
D015088
|
| MeSH Number(s) |
D08.811.913.696.445.625
|
| Concept/Terms |
2',5'-Oligoadenylate Synthetase- 2',5'-Oligoadenylate Synthetase
- 2',5' Oligoadenylate Synthetase
- Synthetase, 2',5'-Oligoadenylate
- 2,5 Oligoadenylate Polymerase
- Oligoadenylate Polymerase, 2,5
- Polymerase, 2,5 Oligoadenylate
- 2',5'-Oligoadenylate Polymerase
- 2',5' Oligoadenylate Polymerase
- Polymerase, 2',5'-Oligoadenylate
- (2'-5')An Polymerase
- ATP-(2'-5')oligo(A)adenylyltransferase
- 2',5'-Oligo(A) Synthetase
- 2',5'-Oligo(A) Polymerase
- 2,5 Oligoadenylate Synthetase
- Oligoadenylate Synthetase, 2,5
- Synthetase, 2,5 Oligoadenylate
- 2-5A Synthetase
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Below are MeSH descriptors whose meaning is more general than "2',5'-Oligoadenylate Synthetase".
Below are MeSH descriptors whose meaning is more specific than "2',5'-Oligoadenylate Synthetase".
This graph shows the total number of publications written about "2',5'-Oligoadenylate Synthetase" by people in this website by year, and whether "2',5'-Oligoadenylate Synthetase" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 1 | 2 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 1 | 2 |
| 2016 | 1 | 1 | 2 |
| 2017 | 3 | 1 | 4 |
| 2018 | 2 | 0 | 2 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 2 | 2 |
| 2021 | 2 | 0 | 2 |
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Below are the most recent publications written about "2',5'-Oligoadenylate Synthetase" by people in Profiles.
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A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance. Elife. 2021 08 17; 10.
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Endomembrane targeting of human OAS1 p46 augments antiviral activity. Elife. 2021 08 03; 10.
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Genome-wide screening of SARS-CoV-2 infection-related genes based on the blood leukocytes sequencing data set of patients with COVID-19. J Med Virol. 2021 09; 93(9):5544-5554.
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A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity. Nat Med. 2021 04; 27(4):659-667.
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Genetic mechanisms of critical illness in COVID-19. Nature. 2021 03; 591(7848):92-98.
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Interferon-Induced Transmembrane Protein (IFITM3) Is Upregulated Explicitly in SARS-CoV-2 Infected Lung Epithelial Cells. Front Immunol. 2020; 11:1372.
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LGP2 plays a critical role in MDA5-mediated antiviral activity against duck enteritis virus. Mol Immunol. 2019 12; 116:160-166.
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Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS. J Exp Med. 2019 05 06; 216(5):1199-1213.
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Expression of the OAS Gene Family Is Highly Modulated in Subjects Affected by Juvenile Dermatomyositis, Resembling an Immune Response to a dsRNA Virus Infection. Int J Mol Sci. 2018 Sep 17; 19(9).
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A novel mechanism of RNase L inhibition: Theiler's virus L* protein prevents 2-5A from binding to RNase L. PLoS Pathog. 2018 04; 14(4):e1006989.