Eduardo N Chini

InstitutionThe Robert and Arlene Kogod Center on Aging
AddressRochester
Minnesota
United States
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    Publication Timeline
    COVID-19 publications
    Bar chart showing 1 Covid-19 publications, with a maximum of 1 publications in November 2020
    All Publications
    Bar chart showing 56 publications over 18 distinct years, with a maximum of 7 publications in 2006
    These graphs show COVID-19 publications by month since August 2019 and all publications written by authors of COVID-19 publications over the past 30 years.

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    Publication Field Summary
    This graph shows the number and percent of publications by field. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. To see the data as text, click here.
    Publication List
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Goplen NP, Wu Y, Son YM, Li C, Wang Z, Cheon IS, Jiang L, Zhu B, Ayasoufi K, Chini EN, Johnson AJ, Vassallo R, Limper AH, Zhang N, Sun J. Tissue-resident CD8+ T cells drive age-associated chronic lung sequelae after viral pneumonia. Sci Immunol. 2020 11 06; 5(53). PMID: 33158975.
      Citations: 20     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    2. Hogan KA, Chini CCS, Chini EN. The Multi-faceted Ecto-enzyme CD38: Roles in Immunomodulation, Cancer, Aging, and Metabolic Diseases. Front Immunol. 2019; 10:1187. PMID: 31214171.
      Citations: 60     Fields:    Translation:HumansAnimals
    3. de Oliveira GC, Kanamori KS, Auxiliadora-Martins M, Chini CCS, Chini EN. Measuring CD38 Hydrolase and Cyclase Activities: 1,N6-Ethenonicotinamide Adenine Dinucleotide (e-NAD) and Nicotinamide Guanine Dinucleotide (NGD) Fluorescence-based Methods. Bio Protoc. 2018 07 20; 8(14). PMID: 30112426.
      Citations: 1     
    4. Tarragó MG, Chini CCS, Kanamori KS, Warner GM, Caride A, de Oliveira GC, Rud M, Samani A, Hein KZ, Huang R, Jurk D, Cho DS, Boslett JJ, Miller JD, Zweier JL, Passos JF, Doles JD, Becherer DJ, Chini EN. A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline. Cell Metab. 2018 May 01; 27(5):1081-1095.e10. PMID: 29719225.
      Citations: 75     Fields:    Translation:HumansAnimalsCells
    5. Chini EN, Chini CCS, Espindola Netto JM, de Oliveira GC, van Schooten W. The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging. Trends Pharmacol Sci. 2018 04; 39(4):424-436. PMID: 29482842.
      Citations: 47     Fields:    Translation:HumansAnimals
    6. Chaker M, Minden A, Chen S, Weiss RH, Chini EN, Mahipal A, Azmi AS. Rho GTPase effectors and NAD metabolism in cancer immune suppression. Expert Opin Ther Targets. 2018 01; 22(1):9-17. PMID: 29207896.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    7. Espindola-Netto JM, Chini CCS, Tarragó M, Wang E, Dutta S, Pal K, Mukhopadhyay D, Sola-Penna M, Chini EN. Preclinical efficacy of the novel competitive NAMPT inhibitor STF-118804 in pancreatic cancer. Oncotarget. 2017 Oct 17; 8(49):85054-85067. PMID: 29156703.
      Citations: 15     Fields:    
    8. Matalonga J, Glaria E, Bresque M, Escande C, Carbó JM, Kiefer K, Vicente R, León TE, Beceiro S, Pascual-García M, Serret J, Sanjurjo L, Morón-Ros S, Riera A, Paytubi S, Juarez A, Sotillo F, Lindbom L, Caelles C, Sarrias MR, Sancho J, Castrillo A, Chini EN, Valledor AF. The Nuclear Receptor LXR Limits Bacterial Infection of Host Macrophages through a Mechanism that Impacts Cellular NAD Metabolism. Cell Rep. 2017 01 31; 18(5):1241-1255. PMID: 28147278.
      Citations: 34     Fields:    Translation:AnimalsCells
    9. Chini CCS, Tarragó MG, Chini EN. NAD and the aging process: Role in life, death and everything in between. Mol Cell Endocrinol. 2017 Nov 05; 455:62-74. PMID: 27825999.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    10. Li F, Wang P, Liu K, Tarrago MG, Lu J, Chini EN, Ma X. A High Dose of Isoniazid Disturbs Endobiotic Homeostasis in Mouse Liver. Drug Metab Dispos. 2016 11; 44(11):1742-1751. PMID: 27531952.
      Citations: 7     Fields:    Translation:AnimalsCells
    11. Camacho-Pereira J, Tarragó MG, Chini CCS, Nin V, Escande C, Warner GM, Puranik AS, Schoon RA, Reid JM, Galina A, Chini EN. CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism. Cell Metab. 2016 06 14; 23(6):1127-1139. PMID: 27304511.
      Citations: 193     Fields:    Translation:AnimalsCells
    12. Tulino R, Benjamin AC, Jolinon N, Smith DL, Chini EN, Carnemolla A, Bates GP. SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington's Disease Mice. PLoS One. 2016; 11(1):e0145425. PMID: 26815359.
      Citations: 11     Fields:    Translation:AnimalsCells
    13. Chini CC, Espindola-Netto JM, Mondal G, Guerrico AM, Nin V, Escande C, Sola-Penna M, Zhang JS, Billadeau DD, Chini EN. SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent Pathway. Clin Cancer Res. 2016 05 15; 22(10):2496-507. PMID: 26655844.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    14. Warner G, Hein KZ, Nin V, Edwards M, Chini CC, Hopp K, Harris PC, Torres VE, Chini EN. Food Restriction Ameliorates the Development of Polycystic Kidney Disease. J Am Soc Nephrol. 2016 05; 27(5):1437-47. PMID: 26538633.
      Citations: 47     Fields:    Translation:AnimalsCells
    15. Mathison A, Escande C, Calvo E, Seo S, White T, Salmonson A, Faubion WA, Buttar N, Iovanna J, Lomberk G, Chini EN, Urrutia R. Phenotypic Characterization of Mice Carrying Homozygous Deletion of KLF11, a Gene in Which Mutations Cause Human Neonatal and MODY VII Diabetes. Endocrinology. 2015 Oct; 156(10):3581-95. PMID: 26248217.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    16. Palmer AK, Tchkonia T, LeBrasseur NK, Chini EN, Xu M, Kirkland JL. Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity. Diabetes. 2015 Jul; 64(7):2289-98. PMID: 26106186.
      Citations: 115     Fields:    Translation:HumansAnimalsCells
    17. Wang Y, Cao Y, Yamada S, Thirunavukkarasu M, Nin V, Joshi M, Rishi MT, Bhattacharya S, Camacho-Pereira J, Sharma AK, Shameer K, Kocher JP, Sanchez JA, Wang E, Hoeppner LH, Dutta SK, Leof EB, Shah V, Claffey KP, Chini EN, Simons M, Terzic A, Maulik N, Mukhopadhyay D. Cardiomyopathy and Worsened Ischemic Heart Failure in SM22-a Cre-Mediated Neuropilin-1 Null Mice: Dysregulation of PGC1a and Mitochondrial Homeostasis. Arterioscler Thromb Vasc Biol. 2015 Jun; 35(6):1401-12. PMID: 25882068.
      Citations: 14     Fields:    Translation:AnimalsCells
    18. Clasen BF, Poulsen MM, Escande C, Pedersen SB, Møller N, Chini EN, Jessen N, Jørgensen JO. Growth hormone signaling in muscle and adipose tissue of obese human subjects: associations with measures of body composition and interaction with resveratrol treatment. J Clin Endocrinol Metab. 2014 Dec; 99(12):E2565-73. PMID: 25050904.
      Citations: 5     Fields:    Translation:AnimalsCells
    19. Roy D, Mondal S, Wang C, He X, Khurana A, Giri S, Hoffmann R, Jung DB, Kim SH, Chini EN, Periera JC, Folmes CD, Mariani A, Dowdy SC, Bakkum-Gamez JN, Riska SM, Oberg AL, Karoly ED, Bell LN, Chien J, Shridhar V. Erratum to: Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab. 2014; 2:24. PMID: 26075069.
      Citations:    
    20. Kong S, Thiruppathi M, Qiu Q, Lin Z, Dong H, Chini EN, Prabhakar BS, Fang D. DBC1 is a suppressor of B cell activation by negatively regulating alternative NF-?B transcriptional activity. J Immunol. 2014 Dec 01; 193(11):5515-24. PMID: 25362179.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    21. Roy D, Mondal S, Wang C, He X, Khurana A, Giri S, Hoffmann R, Jung DB, Kim SH, Chini EN, Periera JC, Folmes CD, Mariani A, Dowdy SC, Bakkum-Gamez JN, Riska SM, Oberg AL, Karoly ED, Bell LN, Chien J, Shridhar V. Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab. 2014; 2:13. PMID: 25225614.
      Citations: 18     
    22. Escande C, Nin V, Pirtskhalava T, Chini CC, Thereza Barbosa M, Mathison A, Urrutia R, Tchkonia T, Kirkland JL, Chini EN. Deleted in Breast Cancer 1 regulates cellular senescence during obesity. Aging Cell. 2014 Oct; 13(5):951-3. PMID: 24992635.
      Citations: 8     Fields:    Translation:Animals
    23. Nin V, Chini CC, Escande C, Capellini V, Chini EN. Deleted in breast cancer 1 (DBC1) protein regulates hepatic gluconeogenesis. J Biol Chem. 2014 Feb 28; 289(9):5518-27. PMID: 24415752.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    24. Calliari A, Bobba N, Escande C, Chini EN. Resveratrol delays Wallerian degeneration in a NAD(+) and DBC1 dependent manner. Exp Neurol. 2014 Jan; 251:91-100. PMID: 24252177.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    25. Chini CC, Guerrico AM, Nin V, Camacho-Pereira J, Escande C, Barbosa MT, Chini EN. Targeting of NAD metabolism in pancreatic cancer cells: potential novel therapy for pancreatic tumors. Clin Cancer Res. 2014 Jan 01; 20(1):120-30. PMID: 24025713.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    26. Chini CC, Escande C, Nin V, Chini EN. DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erba. Biochem J. 2013 May 01; 451(3):453-61. PMID: 23398316.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    27. Lomberk G, Grzenda A, Mathison A, Escande C, Zhang JS, Calvo E, Miller LJ, Iovanna J, Chini EN, Fernandez-Zapico ME, Urrutia R. Krüppel-like factor 11 regulates the expression of metabolic genes via an evolutionarily conserved protein interaction domain functionally disrupted in maturity onset diabetes of the young. J Biol Chem. 2013 Jun 14; 288(24):17745-58. PMID: 23589285.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    28. Escande C, Nin V, Price NL, Capellini V, Gomes AP, Barbosa MT, O'Neil L, White TA, Sinclair DA, Chini EN. Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes. 2013 Apr; 62(4):1084-93. PMID: 23172919.
      Citations: 90     Fields:    Translation:HumansAnimalsCells
    29. Nin V, Escande C, Chini CC, Giri S, Camacho-Pereira J, Matalonga J, Lou Z, Chini EN. Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase. J Biol Chem. 2012 Jul 06; 287(28):23489-501. PMID: 22553202.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    30. Chini CC, Escande C, Nin V, Chini EN. HDAC3 is negatively regulated by the nuclear protein DBC1. J Biol Chem. 2010 Dec 24; 285(52):40830-7. PMID: 21030595.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    31. Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, Leeuwenburgh C, McBurney M, Nabeshima Y, Neri C, Oberdoerffer P, Pestell RG, Rogina B, Sadoshima J, Sartorelli V, Serrano M, Sinclair DA, Steegborn C, Tatar M, Tissenbaum HA, Tong Q, Tsubota K, Vaquero A, Verdin E. Dietary restriction: standing up for sirtuins. Science. 2010 Aug 27; 329(5995):1012-3; author reply 1013-4. PMID: 20798296.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    32. Hartman WR, Pelleymounter LL, Moon I, Kalari K, Liu M, Wu TY, Escande C, Nin V, Chini EN, Weinshilboum RM. CD38 expression, function, and gene resequencing in a human lymphoblastoid cell line-based model system. Leuk Lymphoma. 2010 Jul; 51(7):1315-25. PMID: 20470215.
      Citations: 7     Fields:    Translation:HumansCells
    33. Novak CM, Escande C, Burghardt PR, Zhang M, Barbosa MT, Chini EN, Britton SL, Koch LG, Akil H, Levine JA. Spontaneous activity, economy of activity, and resistance to diet-induced obesity in rats bred for high intrinsic aerobic capacity. Horm Behav. 2010 Aug; 58(3):355-67. PMID: 20350549.
      Citations: 62     Fields:    Translation:Animals
    34. Novak CM, Escande C, Gerber SM, Chini EN, Zhang M, Britton SL, Koch LG, Levine JA. Endurance capacity, not body size, determines physical activity levels: role of skeletal muscle PEPCK. PLoS One. 2009 Jun 12; 4(6):e5869. PMID: 19521512.
      Citations: 32     Fields:    Translation:HumansAnimals
    35. Nagamune K, Hicks LM, Fux B, Brossier F, Chini EN, Sibley LD. Abscisic acid controls calcium-dependent egress and development in Toxoplasma gondii. Nature. 2008 Jan 10; 451(7175):207-10. PMID: 18185591.
      Citations: 83     Fields:    Translation:AnimalsCells
    36. Nagamune K, Moreno SN, Chini EN, Sibley LD. Calcium regulation and signaling in apicomplexan parasites. Subcell Biochem. 2008; 47:70-81. PMID: 18512342.
      Citations: 50     Fields:    Translation:AnimalsCells
    37. Perkins WJ, Taniguchi M, Warner DO, Chini EN, Jones KA. Reduction in soluble guanylyl cyclase-specific activity following prolonged treatment of porcine pulmonary artery with nitric oxide. Am J Physiol Lung Cell Mol Physiol. 2007 Jul; 293(1):L84-95. PMID: 17384083.
      Citations: 5     Translation:Animals
    38. Umesh A, Thompson MA, Chini EN, Yip KP, Sham JS. Integrin ligands mobilize Ca2+ from ryanodine receptor-gated stores and lysosome-related acidic organelles in pulmonary arterial smooth muscle cells. J Biol Chem. 2006 Nov 10; 281(45):34312-23. PMID: 16963791.
      Citations: 15     Fields:    Translation:AnimalsCells
    39. Aksoy P, Escande C, White TA, Thompson M, Soares S, Benech JC, Chini EN. Regulation of SIRT 1 mediated NAD dependent deacetylation: a novel role for the multifunctional enzyme CD38. Biochem Biophys Res Commun. 2006 Oct 13; 349(1):353-9. PMID: 16935261.
      Citations: 62     Fields:    Translation:AnimalsCells
    40. Nakayama T, Penheiter AR, Penheiter SG, Chini EN, Thompson M, Warner DO, Jones KA. Differential effects of volatile anesthetics on M3 muscarinic receptor coupling to the Galphaq heterotrimeric G protein. Anesthesiology. 2006 Aug; 105(2):313-24. PMID: 16871065.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    41. Kip SN, Smelter M, Iyanoye A, Chini EN, Prakash YS, Pabelick CM, Sieck GC. Agonist-induced cyclic ADP ribose production in airway smooth muscle. Arch Biochem Biophys. 2006 Aug 15; 452(2):102-7. PMID: 16846589.
      Citations: 6     Fields:    Translation:AnimalsCells
    42. Soares S, Thompson M, White T, Isbell A, Yamasaki M, Prakash Y, Lund FE, Galione A, Chini EN. NAADP as a second messenger: neither CD38 nor base-exchange reaction are necessary for in vivo generation of NAADP in myometrial cells. Am J Physiol Cell Physiol. 2007 Jan; 292(1):C227-39. PMID: 16790499.
      Citations: 34     Translation:HumansAnimalsCells
    43. Aksoy P, White TA, Thompson M, Chini EN. Regulation of intracellular levels of NAD: a novel role for CD38. Biochem Biophys Res Commun. 2006 Jul 14; 345(4):1386-92. PMID: 16730329.
      Citations: 124     Fields:    Translation:HumansAnimalsCells
    44. White TA, Xue A, Chini EN, Thompson M, Sieck GC, Wylam ME. Role of transient receptor potential C3 in TNF-alpha-enhanced calcium influx in human airway myocytes. Am J Respir Cell Mol Biol. 2006 Aug; 35(2):243-51. PMID: 16574942.
      Citations: 55     Fields:    Translation:HumansCells
    45. Chini EN, Nagamune K, Wetzel DM, Sibley LD. Evidence that the cADPR signalling pathway controls calcium-mediated microneme secretion in Toxoplasma gondii. Biochem J. 2005 Jul 15; 389(Pt 2):269-77. PMID: 15773818.
      Citations: 25     Fields:    Translation:AnimalsCells
    46. Soares SM, Thompson M, Chini EN. Role of the second-messenger cyclic-adenosine 5'-diphosphate-ribose on adrenocorticotropin secretion from pituitary cells. Endocrinology. 2005 May; 146(5):2186-92. PMID: 15718277.
      Citations: 4     Fields:    Translation:AnimalsCells
    47. Burrow B, Burkle C, Warner DO, Chini EN. Postoperative outcome of patients with narcolepsy. A retrospective analysis. J Clin Anesth. 2005 Feb; 17(1):21-5. PMID: 15721725.
      Citations: 8     Fields:    Translation:Humans
    48. Chini EN, Brown MJ, Farrell MA, Charboneau JW. Hypertensive crisis in a patient undergoing percutaneous radiofrequency ablation of an adrenal mass under general anesthesia. Anesth Analg. 2004 Dec; 99(6):1867-1869. PMID: 15562089.
      Citations: 19     Fields:    Translation:Humans
    49. Thompson M, Barata da Silva H, Zielinska W, White TA, Bailey JP, Lund FE, Sieck GC, Chini EN. Role of CD38 in myometrial Ca2+ transients: modulation by progesterone. Am J Physiol Endocrinol Metab. 2004 Dec; 287(6):E1142-8. PMID: 15339743.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    50. Zielinska W, Barata H, Chini EN. Metabolism of cyclic ADP-ribose: Zinc is an endogenous modulator of the cyclase/NAD glycohydrolase ratio of a CD38-like enzyme from human seminal fluid. Life Sci. 2004 Feb 20; 74(14):1781-90. PMID: 14741735.
      Citations: 13     Fields:    Translation:HumansAnimals
    51. Barata H, Thompson M, Zielinska W, Han YS, Mantilla CB, Prakash YS, Feitoza S, Sieck G, Chini EN. The role of cyclic-ADP-ribose-signaling pathway in oxytocin-induced Ca2+ transients in human myometrium cells. Endocrinology. 2004 Feb; 145(2):881-9. PMID: 14563702.
      Citations: 17     Fields:    Translation:HumansCells
    52. Chini EN, Chini CC, Barata da Silva H, Zielinska W. The cyclic-ADP-ribose signaling pathway in human myometrium. Arch Biochem Biophys. 2002 Nov 15; 407(2):152-9. PMID: 12413485.
      Citations: 1     Fields:    Translation:HumansCells
    53. Chini EN, Keller TF, Prakash YS, Pabelick CM, Sieck G. Effect of halothane on cADP-ribose-induced Ca(2+) release system in tracheal smooth muscle. Anesthesiology. 2002 Oct; 97(4):1022-4. PMID: 12357177.
      Citations:    Fields:    Translation:AnimalsCells
    54. Chini EN, De Toledo FG. Nicotinic acid adenine dinucleotide phosphate: a new intracellular second messenger? Am J Physiol Cell Physiol. 2002 Jun; 282(6):C1191-8. PMID: 11997232.
      Citations: 8     Translation:HumansAnimalsCells
    55. Chini EN. Interactions between intracellular Ca2+ stores: Ca2+ released from the NAADP pool potentiates cADPR-induced Ca2+ release. Braz J Med Biol Res. 2002 May; 35(5):543-7. PMID: 12011938.
      Citations:    Fields:    Translation:AnimalsCells
    56. Chini EN, Chini CC, Kato I, Takasawa S, Okamoto H. CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues. Biochem J. 2002 Feb 15; 362(Pt 1):125-30. PMID: 11829748.
      Citations: 25     Fields:    Translation:AnimalsCells