Jonathan A Epstein

InstitutionUniversity of Pennsylvania
AddressUnited States
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    Publication Timeline
    COVID-19 publications
    Bar chart showing 3 Covid-19 publications, with a maximum of 1 publications in January 2021 and June 2021 and October 2021
    All Publications
    Bar chart showing 180 publications over 19 distinct years, with a maximum of 17 publications in 2008
    These graphs show COVID-19 publications by month since August 2019 and all publications written by authors of COVID-19 publications over the past 30 years.

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    Publication Field Summary
    This graph shows the number and percent of publications by field. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. To see the data as text, click here.
    Publication List
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kiseleva AA, Troisi EM, Hensley SE, Kohli RM, Epstein JA. SARS-CoV-2 spike protein binding selectively accelerates substrate-specific catalytic activity of ACE2. J Biochem. 2021 Oct 11; 170(2):299-306. PMID: 33774672.
      Citations: 1     Fields:    Translation:HumansCells
    2. Oakes AH, Epstein JA, Ganguly A, Park SH, Evans CN, Patel MS. Effect of Opt-In vs Opt-Out Framing on Enrollment in a COVID-19 Surveillance Testing Program: The COVID SAFE Randomized Clinical Trial. JAMA Netw Open. 2021 06 01; 4(6):e2112434. PMID: 34081141.
      Citations:    Fields:    Translation:HumansPHPublic Health
    3. Sikka R, Lincoln AE, Adamson BJS, Epstein JA, Krumholz HM. What's Important: Reopening Lessons from the Big Leagues' Experiences with COVID-19. J Bone Joint Surg Am. 2021 01 06; 103(1):1-3. PMID: 33196503.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    4. Sandireddy R, Cibi DM, Gupta P, Singh A, Tee N, Uemura A, Epstein JA, Singh MK. Semaphorin 3E/PlexinD1 signaling is required for cardiac ventricular compaction. JCI Insight. 2019 08 22; 4(16). PMID: 31434798.
      Citations: 12     Fields:    Translation:AnimalsCells
    5. Jain R, Poleshko A, Epstein JA. Beating the odds: programming proliferation in the mammalian heart. Genome Med. 2018 05 18; 10(1):36. PMID: 29776422.
      Citations:    Fields:    Translation:HumansAnimals
    6. Artap S, Manderfield LJ, Smith CL, Poleshko A, Aghajanian H, See K, Li L, Jain R, Epstein JA. Endocardial Hippo signaling regulates myocardial growth and cardiogenesis. Dev Biol. 2018 08 01; 440(1):22-30. PMID: 29727635.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    7. Lin W, Li D, Cheng L, Li L, Liu F, Hand NJ, Epstein JA, Rader DJ. Zinc transporter Slc39a8 is essential for cardiac ventricular compaction. J Clin Invest. 2018 02 01; 128(2):826-833. PMID: 29337306.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    8. Jain R, Epstein JA. Competent for commitment: you've got to have heart! Genes Dev. 2018 01 01; 32(1):4-13. PMID: 29440224.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    9. Epstein JA. CELL FATE DETERMINATION IN 3D: REGULATION OF GENE EXPRESSION VIA CHROMATIN INTERACTIONS WITH THE NUCLEAR MEMBRANE. Trans Am Clin Climatol Assoc. 2018; 129:121-131. PMID: 30166706.
      Citations:    Fields:    Translation:HumansAnimalsCells
    10. Poleshko A, Shah PP, Gupta M, Babu A, Morley MP, Manderfield LJ, Ifkovits JL, Calderon D, Aghajanian H, Sierra-Pagán JE, Sun Z, Wang Q, Li L, Dubois NC, Morrisey EE, Lazar MA, Smith CL, Epstein JA, Jain R. Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction. Cell. 2017 Oct 19; 171(3):573-587.e14. PMID: 29033129.
      Citations: 54     Fields:    Translation:AnimalsCells
    11. Pauerstein PT, Tellez K, Willmarth KB, Park KM, Hsueh B, Efsun Arda H, Gu X, Aghajanian H, Deisseroth K, Epstein JA, Kim SK. A radial axis defined by semaphorin-to-neuropilin signaling controls pancreatic islet morphogenesis. Development. 2017 10 15; 144(20):3744-3754. PMID: 28893946.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    12. Ramjee V, Li D, Manderfield LJ, Liu F, Engleka KA, Aghajanian H, Rodell CB, Lu W, Ho V, Wang T, Li L, Singh A, Cibi DM, Burdick JA, Singh MK, Jain R, Epstein JA. Epicardial YAP/TAZ orchestrate an immunosuppressive response following myocardial infarction. J Clin Invest. 2017 Mar 01; 127(3):899-911. PMID: 28165342.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    13. Epstein JA, Blank PS, Searle BC, Catlin AD, Cologna SM, Olson MT, Backlund PS, Coorssen JR, Yergey AL. ProteinProcessor: A probabilistic analysis using mass accuracy and the MS spectrum. Proteomics. 2016 09; 16(18):2480-90. PMID: 27546229.
      Citations: 2     Fields:    Translation:HumansAnimals
    14. Loh KM, Chen A, Koh PW, Deng TZ, Sinha R, Tsai JM, Barkal AA, Shen KY, Jain R, Morganti RM, Shyh-Chang N, Fernhoff NB, George BM, Wernig G, Salomon REA, Chen Z, Vogel H, Epstein JA, Kundaje A, Talbot WS, Beachy PA, Ang LT, Weissman IL. Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types. Cell. 2016 Jul 14; 166(2):451-467. PMID: 27419872.
      Citations: 109     Fields:    Translation:HumansCells
    15. Aghajanian H, Cho YK, Manderfield LJ, Herling MR, Gupta M, Ho VC, Li L, Degenhardt K, Aharonov A, Tzahor E, Epstein JA. Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor. Nat Commun. 2016 06 30; 7:12038. PMID: 27356767.
      Citations: 19     Fields:    Translation:AnimalsCells
    16. Singh A, Ramesh S, Cibi DM, Yun LS, Li J, Li L, Manderfield LJ, Olson EN, Epstein JA, Singh MK. Hippo Signaling Mediators Yap and Taz Are Required in the Epicardium for Coronary Vasculature Development. Cell Rep. 2016 05 17; 15(7):1384-1393. PMID: 27160901.
      Citations: 47     Fields:    Translation:AnimalsCells
    17. He S, Mansour MR, Zimmerman MW, Ki DH, Layden HM, Akahane K, Gjini E, de Groh ED, Perez-Atayde AR, Zhu S, Epstein JA, Look AT. Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain. Elife. 2016 04 27; 5. PMID: 27130733.
      Citations: 15     Fields:    Translation:AnimalsCells
    18. Yzaguirre AD, Padmanabhan A, de Groh ED, Engleka KA, Li J, Speck NA, Epstein JA. Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos. Elife. 2015 Oct 13; 4:e07780. PMID: 26460546.
      Citations: 8     Fields:    Translation:Animals
    19. Li D, Takeda N, Jain R, Manderfield LJ, Liu F, Li L, Anderson SA, Epstein JA. Hopx distinguishes hippocampal from lateral ventricle neural stem cells. Stem Cell Res. 2015 Nov; 15(3):522-529. PMID: 26451648.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    20. Han S, Zhang R, Jain R, Shi H, Zhang L, Zhou G, Sangwung P, Tugal D, Atkins GB, Prosdocimo DA, Lu Y, Han X, Tso P, Liao X, Epstein JA, Jain MK. Corrigendum: Circadian control of bile acid synthesis by a KLF15-Fgf15 axis. Nat Commun. 2015 Aug 27; 6:8270. PMID: 26527506.
      Citations: 1     Fields:    
    21. Manderfield LJ, Aghajanian H, Engleka KA, Lim LY, Liu F, Jain R, Li L, Olson EN, Epstein JA. Hippo signaling is required for Notch-dependent smooth muscle differentiation of neural crest. Development. 2015 Sep 01; 142(17):2962-71. PMID: 26253400.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    22. Jones A, Opejin A, Henderson JG, Gross C, Jain R, Epstein JA, Flavell RA, Hawiger D. Peripherally Induced Tolerance Depends on Peripheral Regulatory T Cells That Require Hopx To Inhibit Intrinsic IL-2 Expression. J Immunol. 2015 Aug 15; 195(4):1489-97. PMID: 26170384.
      Citations: 20     Fields:    Translation:AnimalsCells
    23. Jain R, Li D, Gupta M, Manderfield LJ, Ifkovits JL, Wang Q, Liu F, Liu Y, Poleshko A, Padmanabhan A, Raum JC, Li L, Morrisey EE, Lu MM, Won KJ, Epstein JA. HEART DEVELOPMENT. Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts. Science. 2015 Jun 26; 348(6242):aaa6071. PMID: 26113728.
      Citations: 51     Fields:    Translation:AnimalsCells
    24. Tomas-Roca L, Tsaalbi-Shtylik A, Jansen JG, Singh MK, Epstein JA, Altunoglu U, Verzijl H, Soria L, van Beusekom E, Roscioli T, Iqbal Z, Gilissen C, Hoischen A, de Brouwer APM, Erasmus C, Schubert D, Brunner H, Pérez Aytés A, Marin F, Aroca P, Kayserili H, Carta A, de Wind N, Padberg GW, van Bokhoven H. De novo mutations in PLXND1 and REV3L cause Möbius syndrome. Nat Commun. 2015 Jun 12; 6:7199. PMID: 26068067.
      Citations: 27     Fields:    Translation:HumansAnimals
    25. Zhou X, Crow AL, Hartiala J, Spindler TJ, Ghazalpour A, Barsky LW, Bennett BJ, Parks BW, Eskin E, Jain R, Epstein JA, Lusis AJ, Adams GB, Allayee H. The Genetic Landscape of Hematopoietic Stem Cell Frequency in Mice. Stem Cell Reports. 2015 Jul 14; 5(1):125-38. PMID: 26050929.
      Citations: 9     Fields:    Translation:AnimalsCells
    26. Jain R, Barkauskas CE, Takeda N, Bowie EJ, Aghajanian H, Wang Q, Padmanabhan A, Manderfield LJ, Gupta M, Li D, Li L, Trivedi CM, Hogan BLM, Epstein JA. Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung. Nat Commun. 2015 Apr 13; 6:6727. PMID: 25865356.
      Citations: 99     Fields:    Translation:HumansAnimalsCells
    27. Butler MG, Iben JR, Marsden KC, Epstein JA, Granato M, Weinstein BM. SNPfisher: tools for probing genetic variation in laboratory-reared zebrafish. Development. 2015 Apr 15; 142(8):1542-52. PMID: 25813542.
      Citations: 15     Fields:    Translation:Animals
    28. Minchin JE, Dahlman I, Harvey CJ, Mejhert N, Singh MK, Epstein JA, Arner P, Torres-Vázquez J, Rawls JF. Plexin D1 determines body fat distribution by regulating the type V collagen microenvironment in visceral adipose tissue. Proc Natl Acad Sci U S A. 2015 Apr 07; 112(14):4363-8. PMID: 25831505.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    29. Roger VL, Boerwinkle E, Crapo JD, Douglas PS, Epstein JA, Granger CB, Greenland P, Kohane I, Psaty BM. Roger et al. respond to "future of population studies". Am J Epidemiol. 2015 Mar 15; 181(6):372-3. PMID: 25743323.
      Citations: 1     Fields:    Translation:Humans
    30. Roger VL, Boerwinkle E, Crapo JD, Douglas PS, Epstein JA, Granger CB, Greenland P, Kohane I, Psaty BM. Strategic transformation of population studies: recommendations of the working group on epidemiology and population sciences from the National Heart, Lung, and Blood Advisory Council and Board of External Experts. Am J Epidemiol. 2015 Mar 15; 181(6):363-8. PMID: 25743324.
      Citations: 22     Fields:    Translation:Humans
    31. Manderfield LJ, Engleka KA, Aghajanian H, Gupta M, Yang S, Li L, Baggs JE, Hogenesch JB, Olson EN, Epstein JA. Pax3 and Hippo Signaling Coordinate Melanocyte Gene Expression in Neural Crest. Cell Rep. 2015 02 10; 10(5):841. PMID: 30849859.
      Citations: 1     Fields:    
    32. Epstein JA, Aghajanian H, Singh MK. Semaphorin signaling in cardiovascular development. Cell Metab. 2015 Feb 03; 21(2):163-173. PMID: 25651171.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    33. Epstein JA, Ingram DA, Hirbe AC, Gutmann DH. A multidisciplinary approach in neurofibromatosis 1--authors' reply. Lancet Neurol. 2015 Jan; 14(1):30-1. PMID: 25496893.
      Citations: 1     Fields:    Translation:Humans
    34. Manderfield LJ, Engleka KA, Aghajanian H, Gupta M, Yang S, Li L, Baggs JE, Hogenesch JB, Olson EN, Epstein JA. Pax3 and hippo signaling coordinate melanocyte gene expression in neural crest. Cell Rep. 2014 Dec 11; 9(5):1885-1895. PMID: 25466249.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    35. Li N, Yousefi M, Nakauka-Ddamba A, Jain R, Tobias J, Epstein JA, Jensen ST, Lengner CJ. Single-cell analysis of proxy reporter allele-marked epithelial cells establishes intestinal stem cell hierarchy. Stem Cell Reports. 2014 Nov 11; 3(5):876-91. PMID: 25418730.
      Citations: 47     Fields:    Translation:AnimalsCells
    36. Wolman MA, de Groh ED, McBride SM, Jongens TA, Granato M, Epstein JA. Modulation of cAMP and ras signaling pathways improves distinct behavioral deficits in a zebrafish model of neurofibromatosis type 1. Cell Rep. 2014 Sep 11; 8(5):1265-70. PMID: 25176649.
      Citations: 31     Fields:    Translation:AnimalsCells
    37. Hogan BL, Barkauskas CE, Chapman HA, Epstein JA, Jain R, Hsia CC, Niklason L, Calle E, Le A, Randell SH, Rock J, Snitow M, Krummel M, Stripp BR, Vu T, White ES, Whitsett JA, Morrisey EE. Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. Cell Stem Cell. 2014 Aug 07; 15(2):123-38. PMID: 25105578.
      Citations: 301     Fields:    Translation:HumansAnimalsCells
    38. Aghajanian H, Choi C, Ho VC, Gupta M, Singh MK, Epstein JA. Semaphorin 3d and semaphorin 3e direct endothelial motility through distinct molecular signaling pathways. J Biol Chem. 2014 Jun 27; 289(26):17971-9. PMID: 24825896.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    39. Gerhardt DM, Pajcini KV, D'altri T, Tu L, Jain R, Xu L, Chen MJ, Rentschler S, Shestova O, Wertheim GB, Tobias JW, Kluk M, Wood AW, Aster JC, Gimotty PA, Epstein JA, Speck N, Bigas A, Pear WS. The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells. Genes Dev. 2014 Mar 15; 28(6):576-93. PMID: 24637115.
      Citations: 26     Fields:    Translation:AnimalsCells
    40. Ifkovits JL, Addis RC, Epstein JA, Gearhart JD. Inhibition of TGFß signaling increases direct conversion of fibroblasts to induced cardiomyocytes. PLoS One. 2014; 9(2):e89678. PMID: 24586958.
      Citations: 83     Fields:    Translation:AnimalsCells
    41. Worzfeld T, Swiercz JM, Sentürk A, Genz B, Korostylev A, Deng S, Xia J, Hoshino M, Epstein JA, Chan AM, Vollmar B, Acker-Palmer A, Kuner R, Offermanns S. Genetic dissection of plexin signaling in vivo. Proc Natl Acad Sci U S A. 2014 Feb 11; 111(6):2194-9. PMID: 24469813.
      Citations: 21     Fields:    Translation:AnimalsCells
    42. Zhao T, Gan Q, Stokes A, Lassiter RN, Wang Y, Chan J, Han JX, Pleasure DE, Epstein JA, Zhou CJ. ß-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation. Development. 2014 Jan; 141(1):148-57. PMID: 24284205.
      Citations: 26     Fields:    Translation:AnimalsCells
    43. Choi YI, Duke-Cohan JS, Tan J, Gui J, Singh MK, Epstein JA, Reinherz EL. Plxnd1 expression in thymocytes regulates their intrathymic migration while that in thymic endothelium impacts medullary topology. Front Immunol. 2013; 4:392. PMID: 24312099.
      Citations: 6     Fields:    
    44. Addis RC, Epstein JA. Induced regeneration--the progress and promise of direct reprogramming for heart repair. Nat Med. 2013 Jul; 19(7):829-36. PMID: 23836233.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    45. Takeda N, Jain R, Li D, Li L, Lu MM, Epstein JA. Lgr5 Identifies Progenitor Cells Capable of Taste Bud Regeneration after Injury. PLoS One. 2013; 8(6):e66314. PMID: 23824276.
      Citations: 28     Fields:    Translation:AnimalsCells
    46. Degenhardt K, Singh MK, Aghajanian H, Massera D, Wang Q, Li J, Li L, Choi C, Yzaguirre AD, Francey LJ, Gallant E, Krantz ID, Gruber PJ, Epstein JA. Semaphorin 3d signaling defects are associated with anomalous pulmonary venous connections. Nat Med. 2013 Jun; 19(6):760-5. PMID: 23685842.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    47. Addis RC, Ifkovits JL, Pinto F, Kellam LD, Esteso P, Rentschler S, Christoforou N, Epstein JA, Gearhart JD. Optimization of direct fibroblast reprogramming to cardiomyocytes using calcium activity as a functional measure of success. J Mol Cell Cardiol. 2013 Jul; 60:97-106. PMID: 23591016.
      Citations: 115     Fields:    Translation:HumansAnimalsCells
    48. Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. Molecular determinants of lung development. Ann Am Thorac Soc. 2013 Apr; 10(2):S12-6. PMID: 23607856.
      Citations: 34     Fields:    Translation:Humans
    49. Meadows SM, Ratliff LA, Singh MK, Epstein JA, Cleaver O. Resolution of defective dorsal aortae patterning in Sema3E-deficient mice occurs via angiogenic remodeling. Dev Dyn. 2013 May; 242(5):580-90. PMID: 23444297.
      Citations: 14     Fields:    Translation:Animals
    50. Singh N, Gupta M, Trivedi CM, Singh MK, Li L, Epstein JA. Murine craniofacial development requires Hdac3-mediated repression of Msx gene expression. Dev Biol. 2013 May 15; 377(2):333-44. PMID: 23506836.
      Citations: 17     Fields:    Translation:AnimalsCells
    51. Parmacek MS, Epstein JA. An epigenetic roadmap for cardiomyocyte differentiation. Circ Res. 2013 Mar 15; 112(6):881-3. PMID: 23493303.
      Citations: 2     Fields:    
    52. Takeda N, Jain R, Leboeuf MR, Padmanabhan A, Wang Q, Li L, Lu MM, Millar SE, Epstein JA. Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells. Development. 2013 Apr; 140(8):1655-64. PMID: 23487314.
      Citations: 38     Fields:    Translation:AnimalsCells
    53. Degenhardt K, Singh MK, Epstein JA. New approaches under development: cardiovascular embryology applied to heart disease. J Clin Invest. 2013 Jan; 123(1):71-4. PMID: 23281412.
      Citations: 5     Fields:    Translation:HumansAnimals
    54. Yang Y, García-Verdugo JM, Soriano-Navarro M, Srinivasan RS, Scallan JP, Singh MK, Epstein JA, Oliver G. Lymphatic endothelial progenitors bud from the cardinal vein and intersomitic vessels in mammalian embryos. Blood. 2012 Sep 13; 120(11):2340-8. PMID: 22859612.
      Citations: 82     Fields:    Translation:AnimalsCells
    55. Rentschler S, Yen AH, Lu J, Petrenko NB, Lu MM, Manderfield LJ, Patel VV, Fishman GI, Epstein JA. Myocardial Notch signaling reprograms cardiomyocytes to a conduction-like phenotype. Circulation. 2012 Aug 28; 126(9):1058-66. PMID: 22837163.
      Citations: 33     Fields:    Translation:AnimalsCells
    56. Shin J, Padmanabhan A, de Groh ED, Lee JS, Haidar S, Dahlberg S, Guo F, He S, Wolman MA, Granato M, Lawson ND, Wolfe SA, Kim SH, Solnica-Krezel L, Kanki JP, Ligon KL, Epstein JA, Look AT. Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development. Dis Model Mech. 2012 Nov; 5(6):881-94. PMID: 22773753.
      Citations: 33     Fields:    Translation:AnimalsCells
    57. Singh MK, Epstein JA. Epicardium-derived cardiac mesenchymal stem cells: expanding the outer limit of heart repair. Circ Res. 2012 Mar 30; 110(7):904-6. PMID: 22461359.
      Citations: 16     Fields:    
    58. Katz TC, Singh MK, Degenhardt K, Rivera-Feliciano J, Johnson RL, Epstein JA, Tabin CJ. Distinct compartments of the proepicardial organ give rise to coronary vascular endothelial cells. Dev Cell. 2012 Mar 13; 22(3):639-50. PMID: 22421048.
      Citations: 134     Fields:    Translation:AnimalsCells
    59. Engleka KA, Manderfield LJ, Brust RD, Li L, Cohen A, Dymecki SM, Epstein JA. Islet1 derivatives in the heart are of both neural crest and second heart field origin. Circ Res. 2012 Mar 30; 110(7):922-6. PMID: 22394517.
      Citations: 55     Fields:    Translation:AnimalsCells
    60. de la Pompa JL, Epstein JA. Coordinating tissue interactions: Notch signaling in cardiac development and disease. Dev Cell. 2012 Feb 14; 22(2):244-54. PMID: 22340493.
      Citations: 108     Fields:    Translation:HumansCells
    61. Zhang H, Qiao H, Frank RS, Huang B, Propert KJ, Margulies S, Ferrari VA, Epstein JA, Zhou R. Spin-labeling magnetic resonance imaging detects increased myocardial blood flow after endothelial cell transplantation in the infarcted heart. Circ Cardiovasc Imaging. 2012 Mar; 5(2):210-7. PMID: 22311739.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    62. Banerjee A, Trivedi CM, Damera G, Jiang M, Jester W, Hoshi T, Epstein JA, Panettieri RA. Trichostatin A abrogates airway constriction, but not inflammation, in murine and human asthma models. Am J Respir Cell Mol Biol. 2012 Feb; 46(2):132-8. PMID: 22298527.
      Citations: 29     Fields:    Translation:HumansAnimals
    63. Boudou T, Legant WR, Mu A, Borochin MA, Thavandiran N, Radisic M, Zandstra PW, Epstein JA, Margulies KB, Chen CS. A microfabricated platform to measure and manipulate the mechanics of engineered cardiac microtissues. Tissue Eng Part A. 2012 May; 18(9-10):910-9. PMID: 22092279.
      Citations: 170     Fields:    Translation:AnimalsCells
    64. Manderfield LJ, High FA, Engleka KA, Liu F, Li L, Rentschler S, Epstein JA. Notch activation of Jagged1 contributes to the assembly of the arterial wall. Circulation. 2012 Jan 17; 125(2):314-23. PMID: 22147907.
      Citations: 54     Fields:    Translation:AnimalsCells
    65. Singh MK, Lu MM, Massera D, Epstein JA. MicroRNA-processing enzyme Dicer is required in epicardium for coronary vasculature development. J Biol Chem. 2011 Nov 25; 286(47):41036-45. PMID: 21969379.
      Citations: 23     Fields:    Translation:AnimalsCells
    66. Zhu C, Smith T, McNulty J, Rayla AL, Lakshmanan A, Siekmann AF, Buffardi M, Meng X, Shin J, Padmanabhan A, Cifuentes D, Giraldez AJ, Look AT, Epstein JA, Lawson ND, Wolfe SA. Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish. Development. 2011 Oct; 138(20):4555-64. PMID: 21937602.
      Citations: 51     Fields:    Translation:AnimalsCells
    67. Singh N, Trivedi CM, Lu M, Mullican SE, Lazar MA, Epstein JA. Histone deacetylase 3 regulates smooth muscle differentiation in neural crest cells and development of the cardiac outflow tract. Circ Res. 2011 Nov 11; 109(11):1240-9. PMID: 21959220.
      Citations: 25     Fields:    Translation:Animals
    68. Li D, Epstein JA. Micro-managing myocyte mitosis. Circ Res. 2011 Sep 02; 109(6):611-3. PMID: 21885834.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    69. Epstein JA. Politicizing NIH funding: a bridge to nowhere. J Clin Invest. 2011 Sep; 121(9):3362-3. PMID: 21881213.
      Citations: 2     Fields:    Translation:Humans
    70. Sun Z, Singh N, Mullican SE, Everett LJ, Li L, Yuan L, Liu X, Epstein JA, Lazar MA. Diet-induced lethality due to deletion of the Hdac3 gene in heart and skeletal muscle. J Biol Chem. 2011 Sep 23; 286(38):33301-9. PMID: 21808063.
      Citations: 47     Fields:    Translation:HumansAnimals
    71. Zygmunt T, Gay CM, Blondelle J, Singh MK, Flaherty KM, Means PC, Herwig L, Krudewig A, Belting HG, Affolter M, Epstein JA, Torres-Vázquez J. Semaphorin-PlexinD1 signaling limits angiogenic potential via the VEGF decoy receptor sFlt1. Dev Cell. 2011 Aug 16; 21(2):301-14. PMID: 21802375.
      Citations: 72     Fields:    Translation:AnimalsCells
    72. Anokye-Danso F, Trivedi CM, Juhr D, Gupta M, Cui Z, Tian Y, Zhang Y, Yang W, Gruber PJ, Epstein JA, Morrisey EE. Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell. 2011 Apr 08; 8(4):376-88. PMID: 21474102.
      Citations: 502     Fields:    Translation:HumansAnimalsCells
    73. Epstein JA. Enhancing discovery and saving money with MERIT. J Clin Invest. 2011 Apr; 121(4):1226. PMID: 21490403.
      Citations: 1     Fields:    Translation:Humans
    74. Olson MT, Epstein JA, Sackett DL, Yergey AL. Production of reliable MALDI spectra with quality threshold clustering of replicates. J Am Soc Mass Spectrom. 2011 Jun; 22(6):969-75. PMID: 21953038.
      Citations: 3     Fields:    Translation:HumansCells
    75. Trivedi CM, Cappola TP, Margulies KB, Epstein JA. Homeodomain only protein x is down-regulated in human heart failure. J Mol Cell Cardiol. 2011 Jun; 50(6):1056-8. PMID: 21382376.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    76. Iben JR, Epstein JA, Bayfield MA, Bruinsma MW, Hasson S, Bacikova D, Ahmad D, Rockwell D, Kittler EL, Zapp ML, Maraia RJ. Comparative whole genome sequencing reveals phenotypic tRNA gene duplication in spontaneous Schizosaccharomyces pombe La mutants. Nucleic Acids Res. 2011 Jun; 39(11):4728-42. PMID: 21317186.
      Citations: 11     Fields:    Translation:AnimalsCells
    77. Rentschler S, Harris BS, Kuznekoff L, Jain R, Manderfield L, Lu MM, Morley GE, Patel VV, Epstein JA. Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways. J Clin Invest. 2011 Feb; 121(2):525-33. PMID: 21266778.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    78. Rentschler S, Epstein JA. Kicking the epicardium up a notch. Circ Res. 2011 Jan 07; 108(1):6-8. PMID: 21212389.
      Citations: 4     Fields:    Translation:AnimalsCells
    79. Trivedi CM, Epstein JA. Heart-healthy hypertrophy. Cell Metab. 2011 Jan 05; 13(1):3-4. PMID: 21195341.
      Citations: 3     Fields:    
    80. Jain R, Engleka KA, Rentschler SL, Manderfield LJ, Li L, Yuan L, Epstein JA. Cardiac neural crest orchestrates remodeling and functional maturation of mouse semilunar valves. J Clin Invest. 2011 Jan; 121(1):422-30. PMID: 21157040.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    81. LeBoeuf M, Terrell A, Trivedi S, Sinha S, Epstein JA, Olson EN, Morrisey EE, Millar SE. Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells. Dev Cell. 2010 Dec 14; 19(6):807-18. PMID: 21093383.
      Citations: 117     Fields:    Translation:HumansAnimalsCells
    82. Albrecht I, Niesner U, Janke M, Menning A, Loddenkemper C, Kühl AA, Lepenies I, Lexberg MH, Westendorf K, Hradilkova K, Grün J, Hamann A, Epstein JA, Chang HD, Tokoyoda K, Radbruch A. Persistence of effector memory Th1 cells is regulated by Hopx. Eur J Immunol. 2010 Nov; 40(11):2993-3006. PMID: 21061432.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    83. Epstein JA. Franklin H. Epstein Lecture. Cardiac development and implications for heart disease. N Engl J Med. 2010 Oct 21; 363(17):1638-47. PMID: 20961247.
      Citations: 39     Fields:    Translation:HumansCells
    84. Lee JS, Padmanabhan A, Shin J, Zhu S, Guo F, Kanki JP, Epstein JA, Look AT. Oligodendrocyte progenitor cell numbers and migration are regulated by the zebrafish orthologs of the NF1 tumor suppressor gene. Hum Mol Genet. 2010 Dec 01; 19(23):4643-53. PMID: 20858602.
      Citations: 24     Fields:    Translation:AnimalsCells
    85. Trivedi CM, Zhu W, Wang Q, Jia C, Kee HJ, Li L, Hannenhalli S, Epstein JA. Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation. Dev Cell. 2010 Sep 14; 19(3):450-9. PMID: 20833366.
      Citations: 63     Fields:    Translation:AnimalsCells
    86. Kapitsinou PP, Liu Q, Unger TL, Rha J, Davidoff O, Keith B, Epstein JA, Moores SL, Erickson-Miller CL, Haase VH. Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia. Blood. 2010 Oct 21; 116(16):3039-48. PMID: 20628150.
      Citations: 118     Fields:    Translation:Animals
    87. Stoller JZ, Huang L, Tan CC, Huang F, Zhou DD, Yang J, Gelb BD, Epstein JA. Ash2l interacts with Tbx1 and is required during early embryogenesis. Exp Biol Med (Maywood). 2010 May; 235(5):569-76. PMID: 20463296.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    88. Degenhardt K, Wright AC, Horng D, Padmanabhan A, Epstein JA. Rapid 3D phenotyping of cardiovascular development in mouse embryos by micro-CT with iodine staining. Circ Cardiovasc Imaging. 2010 May; 3(3):314-22. PMID: 20190279.
      Citations: 104     Fields:    Translation:Animals
    89. Chokas AL, Trivedi CM, Lu MM, Tucker PW, Li S, Epstein JA, Morrisey EE. Foxp1/2/4-NuRD interactions regulate gene expression and epithelial injury response in the lung via regulation of interleukin-6. J Biol Chem. 2010 Apr 23; 285(17):13304-13. PMID: 20185820.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    90. Jain R, Rentschler S, Epstein JA. Notch and cardiac outflow tract development. Ann N Y Acad Sci. 2010 Feb; 1188:184-90. PMID: 20201902.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    91. Degenhardt KR, Milewski RC, Padmanabhan A, Miller M, Singh MK, Lang D, Engleka KA, Wu M, Li J, Zhou D, Antonucci N, Li L, Epstein JA. Distinct enhancers at the Pax3 locus can function redundantly to regulate neural tube and neural crest expressions. Dev Biol. 2010 Mar 15; 339(2):519-27. PMID: 20045680.
      Citations: 27     Fields:    Translation:AnimalsCells
    92. Rentschler S, Jain R, Epstein JA. Tissue-tissue interactions during morphogenesis of the outflow tract. Pediatr Cardiol. 2010 Apr; 31(3):408-13. PMID: 20039033.
      Citations: 12     Fields:    Translation:HumansCells
    93. Potrykus K, Murphy H, Chen X, Epstein JA, Cashel M. Imprecise transcription termination within Escherichia coli greA leader gives rise to an array of short transcripts, GraL. Nucleic Acids Res. 2010 Mar; 38(5):1636-51. PMID: 20008510.
      Citations: 11     Fields:    Translation:Cells
    94. Padmanabhan A, Lee JS, Ismat FA, Lu MM, Lawson ND, Kanki JP, Look AT, Epstein JA. Cardiac and vascular functions of the zebrafish orthologues of the type I neurofibromatosis gene NFI. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22305-10. PMID: 19966217.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    95. Singh MK, Li Y, Li S, Cobb RM, Zhou D, Lu MM, Epstein JA, Morrisey EE, Gruber PJ. Gata4 and Gata5 cooperatively regulate cardiac myocyte proliferation in mice. J Biol Chem. 2010 Jan 15; 285(3):1765-72. PMID: 19889636.
      Citations: 40     Fields:    Translation:AnimalsCells
    96. Zhu W, Trivedi CM, Zhou D, Yuan L, Lu MM, Epstein JA. Inpp5f is a polyphosphoinositide phosphatase that regulates cardiac hypertrophic responsiveness. Circ Res. 2009 Dec 04; 105(12):1240-7. PMID: 19875726.
      Citations: 35     Fields:    Translation:HumansAnimals
    97. Levin MD, Lu MM, Petrenko NB, Hawkins BJ, Gupta TH, Lang D, Buckley PT, Jochems J, Liu F, Spurney CF, Yuan LJ, Jacobson JT, Brown CB, Huang L, Beermann F, Margulies KB, Madesh M, Eberwine JH, Epstein JA, Patel VV. Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers. J Clin Invest. 2009 Nov; 119(11):3420-36. PMID: 19855129.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    98. Epstein JA, Turka LA, Birnbaum M, Koretzky G. The physician's voice in the health care debate. J Clin Invest. 2009 Oct; 119(10):2846. PMID: 20069703.
      Citations: 2     Fields:    Translation:Humans
    99. Parmacek MS, Epstein JA. Cardiomyocyte renewal. N Engl J Med. 2009 Jul 02; 361(1):86-8. PMID: 19571289.
      Citations: 29     Fields:    Translation:HumansCells
    100. Xu J, Ismat FA, Wang T, Lu MM, Antonucci N, Epstein JA. Cardiomyocyte-specific loss of neurofibromin promotes cardiac hypertrophy and dysfunction. Circ Res. 2009 Jul 31; 105(3):304-11. PMID: 19574548.
      Citations: 22     Fields:    Translation:AnimalsCells
    101. High FA, Jain R, Stoller JZ, Antonucci NB, Lu MM, Loomes KM, Kaestner KH, Pear WS, Epstein JA. Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development. J Clin Invest. 2009 Jul; 119(7):1986-96. PMID: 19509466.
      Citations: 78     Fields:    Translation:AnimalsCells
    102. Epstein JA. Reinvestment and recovery. J Clin Invest. 2009 Jun; 119(6):1398. PMID: 19487815.
      Citations:    Fields:    Translation:Humans
    103. Aziz A, Miyake T, Engleka KA, Epstein JA, McDermott JC. Menin expression modulates mesenchymal cell commitment to the myogenic and osteogenic lineages. Dev Biol. 2009 Aug 01; 332(1):116-30. PMID: 19464283.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    104. Nishijo K, Hosoyama T, Bjornson CR, Schaffer BS, Prajapati SI, Bahadur AN, Hansen MS, Blandford MC, McCleish AT, Rubin BP, Epstein JA, Rando TA, Capecchi MR, Keller C. Biomarker system for studying muscle, stem cells, and cancer in vivo. FASEB J. 2009 Aug; 23(8):2681-90. PMID: 19332644.
      Citations: 82     Fields:    Translation:HumansAnimalsCells
    105. Epstein JA, Niemitz EL. Stem cells by the shore: Meeting summary of the 2008 MDI Stem Cell Symposium. Epigenetics. 2009 Feb 16; 4(2):125-6. PMID: 19305143.
      Citations:    Fields:    Translation:HumansAnimalsCells
    106. Griffith AV, Cardenas K, Carter C, Gordon J, Iberg A, Engleka K, Epstein JA, Manley NR, Richie ER. Increased thymus- and decreased parathyroid-fated organ domains in Splotch mutant embryos. Dev Biol. 2009 Mar 01; 327(1):216-27. PMID: 19135046.
      Citations: 18     Fields:    Translation:Animals
    107. Choi YI, Duke-Cohan JS, Ahmed WB, Handley MA, Mann F, Epstein JA, Clayton LK, Reinherz EL. PlexinD1 glycoprotein controls migration of positively selected thymocytes into the medulla. Immunity. 2008 Dec 19; 29(6):888-98. PMID: 19027330.
      Citations: 56     Fields:    Translation:AnimalsCells
    108. Zhang Y, Singh MK, Degenhardt KR, Lu MM, Bennett J, Yoshida Y, Epstein JA. Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects. Dev Biol. 2009 Jan 01; 325(1):82-93. PMID: 18992737.
      Citations: 45     Fields:    Translation:AnimalsCells
    109. Kerkela R, Kockeritz L, Macaulay K, Zhou J, Doble BW, Beahm C, Greytak S, Woulfe K, Trivedi CM, Woodgett JR, Epstein JA, Force T, Huggins GS. Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation. J Clin Invest. 2008 Nov; 118(11):3609-18. PMID: 18830417.
      Citations: 116     Fields:    Translation:AnimalsCells
    110. Liu F, Levin MD, Petrenko NB, Lu MM, Wang T, Yuan LJ, Stout AL, Epstein JA, Patel VV. Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin. J Mol Cell Cardiol. 2008 Dec; 45(6):715-23. PMID: 18926829.
      Citations: 52     Fields:    Translation:Animals
    111. Trivedi CM, Lu MM, Wang Q, Epstein JA. Transgenic overexpression of Hdac3 in the heart produces increased postnatal cardiac myocyte proliferation but does not induce hypertrophy. J Biol Chem. 2008 Sep 26; 283(39):26484-9. PMID: 18625706.
      Citations: 49     Fields:    Translation:AnimalsCells
    112. Granger A, Abdullah I, Huebner F, Stout A, Wang T, Huebner T, Epstein JA, Gruber PJ. Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice. FASEB J. 2008 Oct; 22(10):3549-60. PMID: 18606865.
      Citations: 119     Fields:    Translation:AnimalsCells
    113. Lagha M, Kormish JD, Rocancourt D, Manceau M, Epstein JA, Zaret KS, Relaix F, Buckingham ME. Pax3 regulation of FGF signaling affects the progression of embryonic progenitor cells into the myogenic program. Genes Dev. 2008 Jul 01; 22(13):1828-37. PMID: 18593883.
      Citations: 64     Fields:    Translation:AnimalsCells
    114. Wu M, Li J, Engleka KA, Zhou B, Lu MM, Plotkin JB, Epstein JA. Persistent expression of Pax3 in the neural crest causes cleft palate and defective osteogenesis in mice. J Clin Invest. 2008 Jun; 118(6):2076-87. PMID: 18483623.
      Citations: 36     Fields:    Translation:Animals
    115. De Toni A, Zbinden M, Epstein JA, Ruiz i Altaba A, Prochiantz A, Caillé I. Regulation of survival in adult hippocampal and glioblastoma stem cell lineages by the homeodomain-only protein HOP. Neural Dev. 2008 May 28; 3:13. PMID: 18507846.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    116. Tan CC, Sindhu KV, Li S, Nishio H, Stoller JZ, Oishi K, Puttreddy S, Lee TJ, Epstein JA, Walsh MJ, Gelb BD. Transcription factor Ap2delta associates with Ash2l and ALR, a trithorax family histone methyltransferase, to activate Hoxc8 transcription. Proc Natl Acad Sci U S A. 2008 May 27; 105(21):7472-7. PMID: 18495928.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    117. Stoller JZ, Degenhardt KR, Huang L, Zhou DD, Lu MM, Epstein JA. Cre reporter mouse expressing a nuclear localized fusion of GFP and beta-galactosidase reveals new derivatives of Pax3-expressing precursors. Genesis. 2008 Apr; 46(4):200-4. PMID: 18395835.
      Citations: 30     Fields:    Translation:AnimalsCells
    118. Epstein JA. Currying favor for the heart. J Clin Invest. 2008 Mar; 118(3):850-2. PMID: 18292806.
      Citations: 6     Fields:    Translation:HumansAnimals
    119. High FA, Lu MM, Pear WS, Loomes KM, Kaestner KH, Epstein JA. Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development. Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):1955-9. PMID: 18245384.
      Citations: 140     Fields:    Translation:AnimalsCells
    120. Huang J, Cheng L, Li J, Chen M, Zhou D, Lu MM, Proweller A, Epstein JA, Parmacek MS. Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice. J Clin Invest. 2008 Feb; 118(2):515-25. PMID: 18188448.
      Citations: 67     Fields:    Translation:AnimalsCells
    121. Hori K, Cholewa-Waclaw J, Nakada Y, Glasgow SM, Masui T, Henke RM, Wildner H, Martarelli B, Beres TM, Epstein JA, Magnuson MA, Macdonald RJ, Birchmeier C, Johnson JE. A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling. Genes Dev. 2008 Jan 15; 22(2):166-78. PMID: 18198335.
      Citations: 73     Fields:    Translation:AnimalsCells
    122. High FA, Epstein JA. The multifaceted role of Notch in cardiac development and disease. Nat Rev Genet. 2008 Jan; 9(1):49-61. PMID: 18071321.
      Citations: 139     Fields:    Translation:HumansAnimalsCells
    123. Xu J, Ismat FA, Wang T, Yang J, Epstein JA. NF1 regulates a Ras-dependent vascular smooth muscle proliferative injury response. Circulation. 2007 Nov 06; 116(19):2148-56. PMID: 17967772.
      Citations: 29     Fields:    Translation:AnimalsCells
    124. Engleka KA, Wu M, Zhang M, Antonucci NB, Epstein JA. Menin is required in cranial neural crest for palatogenesis and perinatal viability. Dev Biol. 2007 Nov 15; 311(2):524-37. PMID: 17927973.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    125. Vasyutina E, Lenhard DC, Wende H, Erdmann B, Epstein JA, Birchmeier C. RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4443-8. PMID: 17360543.
      Citations: 91     Fields:    Translation:AnimalsCells
    126. Trivedi CM, Luo Y, Yin Z, Zhang M, Zhu W, Wang T, Floss T, Goettlicher M, Noppinger PR, Wurst W, Ferrari VA, Abrams CS, Gruber PJ, Epstein JA. Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity. Nat Med. 2007 Mar; 13(3):324-31. PMID: 17322895.
      Citations: 206     Fields:    Translation:AnimalsCells
    127. High FA, Zhang M, Proweller A, Tu L, Parmacek MS, Pear WS, Epstein JA. An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation. J Clin Invest. 2007 Feb; 117(2):353-63. PMID: 17273555.
      Citations: 117     Fields:    Translation:HumansAnimalsCells
    128. Campbell JM, Vestal ML, Blank PS, Stein SE, Epstein JA, Yergey AL. Fragmentation of leucine enkephalin as a function of laser fluence in a MALDI TOF-TOF. J Am Soc Mass Spectrom. 2007 Apr; 18(4):607-16. PMID: 17204430.
      Citations: 5     Fields:    
    129. High F, Epstein JA. Signalling pathways regulating cardiac neural crest migration and differentiation. Novartis Found Symp. 2007; 283:152-61; discussion 161-4, 238-41. PMID: 18300420.
      Citations: 9     Fields:    Translation:AnimalsCells
    130. Luo Y, High FA, Epstein JA, Radice GL. N-cadherin is required for neural crest remodeling of the cardiac outflow tract. Dev Biol. 2006 Nov 15; 299(2):517-28. PMID: 17014840.
      Citations: 42     Fields:    Translation:AnimalsCells
    131. Kook H, Yung WW, Simpson RJ, Kee HJ, Shin S, Lowry JA, Loughlin FE, Yin Z, Epstein JA, Mackay JP. Analysis of the structure and function of the transcriptional coregulator HOP. Biochemistry. 2006 Sep 05; 45(35):10584-90. PMID: 16939210.
      Citations: 16     Fields:    Translation:AnimalsCells
    132. Hannenhalli S, Putt ME, Gilmore JM, Wang J, Parmacek MS, Epstein JA, Morrisey EE, Margulies KB, Cappola TP. Transcriptional genomics associates FOX transcription factors with human heart failure. Circulation. 2006 Sep 19; 114(12):1269-76. PMID: 16952980.
      Citations: 98     Fields:    Translation:HumansAnimalsCells
    133. Ismat FA, Xu J, Lu MM, Epstein JA. The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice. J Clin Invest. 2006 Sep; 116(9):2378-84. PMID: 16906226.
      Citations: 27     Fields:    Translation:AnimalsCells
    134. Olson MT, Epstein JA, Yergey AL. De novo peptide sequencing using exhaustive enumeration of peptide composition. J Am Soc Mass Spectrom. 2006 Aug; 17(8):1041-1049. PMID: 16735127.
      Citations: 11     Fields:    Translation:Cells
    135. Liu S, Liu F, Schneider AE, St Amand T, Epstein JA, Gutstein DE. Distinct cardiac malformations caused by absence of connexin 43 in the neural crest and in the non-crest neural tube. Development. 2006 May; 133(10):2063-73. PMID: 16624854.
      Citations: 20     Fields:    Translation:Animals
    136. Nowotschin S, Liao J, Gage PJ, Epstein JA, Campione M, Morrow BE. Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field. Development. 2006 Apr; 133(8):1565-73. PMID: 16556915.
      Citations: 57     Fields:    Translation:AnimalsCells
    137. Yin Z, Gonzales L, Kolla V, Rath N, Zhang Y, Lu MM, Kimura S, Ballard PL, Beers MF, Epstein JA, Morrisey EE. Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression. Am J Physiol Lung Cell Mol Physiol. 2006 Aug; 291(2):L191-9. PMID: 16510470.
      Citations: 48     Translation:HumansAnimalsCells
    138. St Amand TR, Lu JT, Zamora M, Gu Y, Stricker J, Hoshijima M, Epstein JA, Ross JJ, Ruiz-Lozano P, Chien KR. Distinct roles of HF-1b/Sp4 in ventricular and neural crest cells lineages affect cardiac conduction system development. Dev Biol. 2006 Mar 15; 291(2):208-17. PMID: 16430881.
      Citations: 12     Fields:    Translation:AnimalsCells
    139. Schienda J, Engleka KA, Jun S, Hansen MS, Epstein JA, Tabin CJ, Kunkel LM, Kardon G. Somitic origin of limb muscle satellite and side population cells. Proc Natl Acad Sci U S A. 2006 Jan 24; 103(4):945-50. PMID: 16418263.
      Citations: 76     Fields:    Translation:AnimalsCells
    140. Kee HJ, Sohn IS, Nam KI, Park JE, Qian YR, Yin Z, Ahn Y, Jeong MH, Bang YJ, Kim N, Kim JK, Kim KK, Epstein JA, Kook H. Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic banding. Circulation. 2006 Jan 03; 113(1):51-9. PMID: 16380549.
      Citations: 122     Fields:    Translation:Animals
    141. Wynder C, Hakimi MA, Epstein JA, Shilatifard A, Shiekhattar R. Recruitment of MLL by HMG-domain protein iBRAF promotes neural differentiation. Nat Cell Biol. 2005 Nov; 7(11):1113-7. PMID: 16227968.
      Citations: 36     Fields:    Translation:AnimalsCells
    142. Wang J, Sridurongrit S, Dudas M, Thomas P, Nagy A, Schneider MD, Epstein JA, Kaartinen V. Atrioventricular cushion transformation is mediated by ALK2 in the developing mouse heart. Dev Biol. 2005 Oct 01; 286(1):299-310. PMID: 16140292.
      Citations: 80     Fields:    Translation:AnimalsCells
    143. Stoller JZ, Epstein JA. Cardiac neural crest. Semin Cell Dev Biol. 2005 Dec; 16(6):704-15. PMID: 16054405.
      Citations: 75     Fields:    Translation:HumansAnimalsCells
    144. Epstein JA, Parmacek MS. Recent advances in cardiac development with therapeutic implications for adult cardiovascular disease. Circulation. 2005 Jul 26; 112(4):592-7. PMID: 16043659.
      Citations: 14     Fields:    Translation:HumansAnimals
    145. Ackerman KG, Herron BJ, Vargas SO, Huang H, Tevosian SG, Kochilas L, Rao C, Pober BR, Babiuk RP, Epstein JA, Greer JJ, Beier DR. Fog2 is required for normal diaphragm and lung development in mice and humans. PLoS Genet. 2005 Jul; 1(1):58-65. PMID: 16103912.
      Citations: 75     Fields:    
    146. Briegel KJ, Baldwin HS, Epstein JA, Joyner AL. Congenital heart disease reminiscent of partial trisomy 2p syndrome in mice transgenic for the transcription factor Lbh. Development. 2005 Jul; 132(14):3305-16. PMID: 15958514.
      Citations: 25     Fields:    Translation:AnimalsCells
    147. Li J, Zhu X, Chen M, Cheng L, Zhou D, Lu MM, Du K, Epstein JA, Parmacek MS. Myocardin-related transcription factor B is required in cardiac neural crest for smooth muscle differentiation and cardiovascular development. Proc Natl Acad Sci U S A. 2005 Jun 21; 102(25):8916-21. PMID: 15951419.
      Citations: 56     Fields:    Translation:AnimalsCells
    148. Engleka KA, Gitler AD, Zhang M, Zhou DD, High FA, Epstein JA. Insertion of Cre into the Pax3 locus creates a new allele of Splotch and identifies unexpected Pax3 derivatives. Dev Biol. 2005 Apr 15; 280(2):396-406. PMID: 15882581.
      Citations: 123     Fields:    Translation:AnimalsCells
    149. Brown CB, Engleka KA, Wenning J, Min Lu M, Epstein JA. Identification of a hypaxial somite enhancer element regulating Pax3 expression in migrating myoblasts and characterization of hypaxial muscle Cre transgenic mice. Genesis. 2005 Apr; 41(4):202-9. PMID: 15789408.
      Citations: 26     Fields:    Translation:AnimalsCells
    150. Ismat FA, Zhang M, Kook H, Huang B, Zhou R, Ferrari VA, Epstein JA, Patel VV. Homeobox protein Hop functions in the adult cardiac conduction system. Circ Res. 2005 Apr 29; 96(8):898-903. PMID: 15790958.
      Citations: 30     Fields:    Translation:Animals
    151. Abdullah I, Lepore JJ, Epstein JA, Parmacek MS, Gruber PJ. MRL mice fail to heal the heart in response to ischemia-reperfusion injury. Wound Repair Regen. 2005 Mar-Apr; 13(2):205-8. PMID: 15828946.
      Citations: 16     Fields:    Translation:Animals
    152. Lang D, Lu MM, Huang L, Engleka KA, Zhang M, Chu EY, Lipner S, Skoultchi A, Millar SE, Epstein JA. Pax3 functions at a nodal point in melanocyte stem cell differentiation. Nature. 2005 Feb 24; 433(7028):884-7. PMID: 15729346.
      Citations: 132     Fields:    Translation:HumansAnimalsCells
    153. Parmacek MS, Epstein JA. Pursuing cardiac progenitors: regeneration redux. Cell. 2005 Feb 11; 120(3):295-8. PMID: 15707888.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    154. Stoller JZ, Epstein JA. Identification of a novel nuclear localization signal in Tbx1 that is deleted in DiGeorge syndrome patients harboring the 1223delC mutation. Hum Mol Genet. 2005 Apr 01; 14(7):885-92. PMID: 15703190.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    155. Epstein FH, Epstein JA. A perspective on the value of aquatic models in biomedical research. Exp Biol Med (Maywood). 2005 Jan; 230(1):1-7. PMID: 15618120.
      Citations: 1     Fields:    Translation:Animals
    156. Horwitz PA, Tsai EJ, Putt ME, Gilmore JM, Lepore JJ, Parmacek MS, Kao AC, Desai SS, Goldberg LR, Brozena SC, Jessup ML, Epstein JA, Cappola TP. Detection of cardiac allograft rejection and response to immunosuppressive therapy with peripheral blood gene expression. Circulation. 2004 Dec 21; 110(25):3815-21. PMID: 15583081.
      Citations: 43     Fields:    Translation:Humans
    157. Araki T, Mohi MG, Ismat FA, Bronson RT, Williams IR, Kutok JL, Yang W, Pao LI, Gilliland DG, Epstein JA, Neel BG. Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation. Nat Med. 2004 Aug; 10(8):849-57. PMID: 15273746.
      Citations: 180     Fields:    Translation:Animals
    158. Kaartinen V, Dudas M, Nagy A, Sridurongrit S, Lu MM, Epstein JA. Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells. Development. 2004 Jul; 131(14):3481-90. PMID: 15226263.
      Citations: 89     Fields:    Translation:AnimalsCells
    159. Gitler AD, Lu MM, Epstein JA. PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development. Dev Cell. 2004 Jul; 7(1):107-16. PMID: 15239958.
      Citations: 133     Fields:    Translation:HumansAnimalsCells
    160. Torres-Vázquez J, Gitler AD, Fraser SD, Berk JD, Fishman MC, Childs S, Epstein JA, Weinstein BM. Semaphorin-plexin signaling guides patterning of the developing vasculature. Dev Cell. 2004 Jul; 7(1):117-23. PMID: 15239959.
      Citations: 130     Fields:    Translation:HumansAnimalsCells
    161. Liao J, Kochilas L, Nowotschin S, Arnold JS, Aggarwal VS, Epstein JA, Brown MC, Adams J, Morrow BE. Full spectrum of malformations in velo-cardio-facial syndrome/DiGeorge syndrome mouse models by altering Tbx1 dosage. Hum Mol Genet. 2004 Aug 01; 13(15):1577-85. PMID: 15190012.
      Citations: 99     Fields:    Translation:Animals
    162. Akiyama H, Chaboissier MC, Behringer RR, Rowitch DH, Schedl A, Epstein JA, de Crombrugghe B. Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa. Proc Natl Acad Sci U S A. 2004 Apr 27; 101(17):6502-7. PMID: 15096597.
      Citations: 92     Fields:    Translation:Animals
    163. Chang CP, McDill BW, Neilson JR, Joist HE, Epstein JA, Crabtree GR, Chen F. Calcineurin is required in urinary tract mesenchyme for the development of the pyeloureteral peristaltic machinery. J Clin Invest. 2004 Apr; 113(7):1051-8. PMID: 15057312.
      Citations: 65     Fields:    Translation:HumansAnimals
    164. Brown CB, Wenning JM, Lu MM, Epstein DJ, Meyers EN, Epstein JA. Cre-mediated excision of Fgf8 in the Tbx1 expression domain reveals a critical role for Fgf8 in cardiovascular development in the mouse. Dev Biol. 2004 Mar 01; 267(1):190-202. PMID: 14975726.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    165. Gruber PJ, Epstein JA. Development gone awry: congenital heart disease. Circ Res. 2004 Feb 20; 94(3):273-83. PMID: 14976138.
      Citations: 32     Fields:    Translation:HumansAnimals
    166. Gitler AD, Kong Y, Choi JK, Zhu Y, Pear WS, Epstein JA. Tie2-Cre-induced inactivation of a conditional mutant Nf1 allele in mouse results in a myeloproliferative disorder that models juvenile myelomonocytic leukemia. Pediatr Res. 2004 Apr; 55(4):581-4. PMID: 14739366.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    167. Milewski RC, Chi NC, Li J, Brown C, Lu MM, Epstein JA. Identification of minimal enhancer elements sufficient for Pax3 expression in neural crest and implication of Tead2 as a regulator of Pax3. Development. 2004 Feb; 131(4):829-37. PMID: 14736747.
      Citations: 48     Fields:    Translation:AnimalsCells
    168. Gitler AD, Lu MM, Jiang YQ, Epstein JA, Gruber PJ. Molecular markers of cardiac endocardial cushion development. Dev Dyn. 2003 Dec; 228(4):643-50. PMID: 14648841.
      Citations: 45     Fields:    Translation:AnimalsCells
    169. Epstein JA, Neel BG. Signal transduction: an eye on organ development. Nature. 2003 Nov 20; 426(6964):238-9. PMID: 14628032.
      Citations: 1     Fields:    Translation:AnimalsCells
    170. Katz SG, Williams A, Yang J, Fujiwara Y, Tsang AP, Epstein JA, Orkin SH. Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14030-5. PMID: 14614148.
      Citations: 19     Fields:    Translation:Animals
    171. Lang D, Brown CB, Milewski R, Jiang YQ, Lu MM, Epstein JA. Distinct enhancers regulate neural expression of Pax7. Genomics. 2003 Nov; 82(5):553-60. PMID: 14559212.
      Citations: 8     Fields:    Translation:AnimalsCells
    172. Kook H, Epstein JA. Hopping to the beat. Hop regulation of cardiac gene expression. Trends Cardiovasc Med. 2003 Oct; 13(7):261-4. PMID: 14522464.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    173. Kook H, Lepore JJ, Gitler AD, Lu MM, Wing-Man Yung W, Mackay J, Zhou R, Ferrari V, Gruber P, Epstein JA. Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop. J Clin Invest. 2003 Sep; 112(6):863-71. PMID: 12975471.
      Citations: 123     Fields:    Translation:HumansAnimalsCells
    174. Bowen NJ, Jordan IK, Epstein JA, Wood V, Levin HL. Retrotransposons and their recognition of pol II promoters: a comprehensive survey of the transposable elements from the complete genome sequence of Schizosaccharomyces pombe. Genome Res. 2003 Sep; 13(9):1984-97. PMID: 12952871.
      Citations: 71     Fields:    Translation:AnimalsCells
    175. Lang D, Epstein JA. Sox10 and Pax3 physically interact to mediate activation of a conserved c-RET enhancer. Hum Mol Genet. 2003 Apr 15; 12(8):937-45. PMID: 12668617.
      Citations: 67     Fields:    Translation:HumansAnimalsCells
    176. Gitler AD, Epstein JA. Regulating heart development: the role of Nf1. Cell Cycle. 2003 Mar-Apr; 2(2):96-8. PMID: 12695655.
      Citations: 4     Translation:HumansAnimalsCells
    177. Gitler AD, Zhu Y, Ismat FA, Lu MM, Yamauchi Y, Parada LF, Epstein JA. Nf1 has an essential role in endothelial cells. Nat Genet. 2003 Jan; 33(1):75-9. PMID: 12469121.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    178. Kochilas L, Merscher-Gomez S, Lu MM, Potluri V, Liao J, Kucherlapati R, Morrow B, Epstein JA. The role of neural crest during cardiac development in a mouse model of DiGeorge syndrome. Dev Biol. 2002 Nov 01; 251(1):157-66. PMID: 12413905.
      Citations: 24     Fields:    Translation:Animals
    179. Chen F, Kook H, Milewski R, Gitler AD, Lu MM, Li J, Nazarian R, Schnepp R, Jen K, Biben C, Runke G, Mackay JP, Novotny J, Schwartz RJ, Harvey RP, Mullins MC, Epstein JA. Hop is an unusual homeobox gene that modulates cardiac development. Cell. 2002 Sep 20; 110(6):713-23. PMID: 12297045.
      Citations: 95     Fields:    Translation:AnimalsCells
    180. Glaser R, Lu MM, Narula N, Epstein JA. Smooth muscle cells, but not myocytes, of host origin in transplanted human hearts. Circulation. 2002 Jul 02; 106(1):17-9. PMID: 12093763.
      Citations: 40     Fields:    Translation:HumansCells
    181. Epstein JA, Rader DJ, Parmacek MS. Perspective: cardiovascular disease in the postgenomic era--lessons learned and challenges ahead. Endocrinology. 2002 Jun; 143(6):2045-50. PMID: 12021168.
      Citations: 3     Fields:    Translation:HumansAnimals
    182. Friedman JM, Arbiser J, Epstein JA, Gutmann DH, Huot SJ, Lin AE, McManus B, Korf BR. Cardiovascular disease in neurofibromatosis 1: report of the NF1 Cardiovascular Task Force. Genet Med. 2002 May-Jun; 4(3):105-11. PMID: 12180143.
      Citations: 87     Fields:    Translation:Humans
    183. Chi N, Epstein JA. Getting your Pax straight: Pax proteins in development and disease. Trends Genet. 2002 Jan; 18(1):41-7. PMID: 11750700.
      Citations: 130     Fields:    Translation:HumansAnimals