Immunoglobulin Fab Fragments
"Immunoglobulin Fab Fragments" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
| Descriptor ID |
D007140
|
| MeSH Number(s) |
D12.644.541.500.650 D12.776.124.486.485.680.650 D12.776.124.790.651.680.650 D12.776.377.715.548.680.650
|
| Concept/Terms |
Immunoglobulin Fab Fragments- Immunoglobulin Fab Fragments
- Fab Fragments, Immunoglobulin
- Immunoglobulins, Fab Fragment
- Fab Fragment Immunoglobulins
- Fragment Immunoglobulins, Fab
- Immunoglobulin Fab Fragment
- Fab Fragment, Immunoglobulin
- Fab Immunoglobulin Fragments
- Immunoglobulin Fragments, Fab
- Fab Fragments
- Immunoglobulins, Fab
|
Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Fab Fragments".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Fab Fragments".
This graph shows the total number of publications written about "Immunoglobulin Fab Fragments" by people in this website by year, and whether "Immunoglobulin Fab Fragments" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 10 | 12 | 22 |
| 1992 | 11 | 12 | 23 |
| 1993 | 5 | 12 | 17 |
| 1994 | 13 | 7 | 20 |
| 1995 | 14 | 17 | 31 |
| 1996 | 6 | 11 | 17 |
| 1997 | 20 | 14 | 34 |
| 1998 | 20 | 13 | 33 |
| 1999 | 18 | 15 | 33 |
| 2000 | 10 | 8 | 18 |
| 2001 | 12 | 11 | 23 |
| 2002 | 79 | 55 | 134 |
| 2003 | 79 | 73 | 152 |
| 2004 | 69 | 67 | 136 |
| 2005 | 66 | 46 | 112 |
| 2006 | 56 | 48 | 104 |
| 2007 | 62 | 60 | 122 |
| 2008 | 70 | 36 | 106 |
| 2009 | 53 | 57 | 110 |
| 2010 | 69 | 58 | 127 |
| 2011 | 52 | 52 | 104 |
| 2012 | 49 | 50 | 99 |
| 2013 | 84 | 51 | 135 |
| 2014 | 55 | 45 | 100 |
| 2015 | 49 | 36 | 85 |
| 2016 | 40 | 35 | 75 |
| 2017 | 29 | 30 | 59 |
| 2018 | 31 | 30 | 61 |
| 2019 | 7 | 5 | 12 |
| 2020 | 2 | 8 | 10 |
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Below are the most recent publications written about "Immunoglobulin Fab Fragments" by people in Profiles.
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Biosensing Cytokine IL-6: A Comparative Analysis of Natural and Synthetic Receptors. Biosensors (Basel). 2020 Aug 24; 10(9).
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Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient. Nat Struct Mol Biol. 2020 10; 27(10):950-958.
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Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody. Science. 2020 09 18; 369(6510):1505-1509.
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Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike. Nature. 2020 08; 584(7821):450-456.
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High-Dose Intravenous Immunoglobulins in the Treatment of Severe Acute Viral Pneumonia: The Known Mechanisms and Clinical Effects. Front Immunol. 2020; 11:1660.
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A perspective on potential antibody-dependent enhancement of SARS-CoV-2. Nature. 2020 08; 584(7821):353-363.
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Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies. Cell. 2020 08 20; 182(4):828-842.e16.
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Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody. Nature. 2020 07; 583(7815):290-295.
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Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry. J Virol. 2020 02 14; 94(5).
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Development of a hyperimmune equine serum therapy for COVID-19 in Argentina. Medicina (B Aires). 2020; 80 Suppl 3:1-6.