Immunoglobulin Fab Fragments
"Immunoglobulin Fab Fragments" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
| Descriptor ID |
D007140
|
| MeSH Number(s) |
D12.644.541.500.650 D12.776.124.486.485.680.650 D12.776.124.790.651.680.650 D12.776.377.715.548.680.650
|
| Concept/Terms |
Immunoglobulin Fab Fragments- Immunoglobulin Fab Fragments
- Fab Fragments, Immunoglobulin
- Immunoglobulins, Fab Fragment
- Fab Fragment Immunoglobulins
- Fragment Immunoglobulins, Fab
- Immunoglobulin Fab Fragment
- Fab Fragment, Immunoglobulin
- Fab Immunoglobulin Fragments
- Immunoglobulin Fragments, Fab
- Fab Fragments
- Immunoglobulins, Fab
|
Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Fab Fragments".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Fab Fragments".
This graph shows the total number of publications written about "Immunoglobulin Fab Fragments" by people in this website by year, and whether "Immunoglobulin Fab Fragments" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 5 | 5 | 10 |
| 1993 | 4 | 3 | 7 |
| 1994 | 4 | 4 | 8 |
| 1995 | 12 | 8 | 20 |
| 1996 | 7 | 5 | 12 |
| 1997 | 16 | 7 | 23 |
| 1998 | 10 | 5 | 15 |
| 1999 | 7 | 3 | 10 |
| 2000 | 5 | 7 | 12 |
| 2001 | 10 | 4 | 14 |
| 2002 | 58 | 42 | 100 |
| 2003 | 56 | 54 | 110 |
| 2004 | 53 | 60 | 113 |
| 2005 | 50 | 39 | 89 |
| 2006 | 38 | 34 | 72 |
| 2007 | 42 | 41 | 83 |
| 2008 | 52 | 23 | 75 |
| 2009 | 40 | 42 | 82 |
| 2010 | 49 | 40 | 89 |
| 2011 | 35 | 41 | 76 |
| 2012 | 40 | 36 | 76 |
| 2013 | 69 | 37 | 106 |
| 2014 | 39 | 37 | 76 |
| 2015 | 39 | 27 | 66 |
| 2016 | 31 | 20 | 51 |
| 2017 | 19 | 24 | 43 |
| 2018 | 20 | 22 | 42 |
| 2019 | 1 | 3 | 4 |
| 2020 | 2 | 9 | 11 |
| 2021 | 4 | 2 | 6 |
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Below are the most recent publications written about "Immunoglobulin Fab Fragments" by people in Profiles.
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Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants. Science. 2021 Aug 13; 373(6556).
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Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies. Cell. 2021 05 27; 184(11):2955-2972.e25.
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Engineered Ultra-High Affinity Synthetic Antibodies for SARS-CoV-2 Neutralization and Detection. J Mol Biol. 2021 05 14; 433(10):166956.
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SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms. Cell. 2021 05 13; 184(10):2605-2617.e18.
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Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein. Cell. 2021 04 29; 184(9):2316-2331.e15.
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Neutralizing Human Antibodies against Severe Acute Respiratory Syndrome Coronavirus 2 Isolated from a Human Synthetic Fab Phage Display Library. Int J Mol Sci. 2021 Feb 15; 22(4).
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Bispecific VH/Fab antibodies targeting neutralizing and non-neutralizing Spike epitopes demonstrate enhanced potency against SARS-CoV-2. MAbs. 2021 Jan-Dec; 13(1):1893426.
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Cross-Neutralization of a SARS-CoV-2 Antibody to a Functionally Conserved Site Is Mediated by Avidity. Immunity. 2020 12 15; 53(6):1272-1280.e5.
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Development of Patient-Derived Human Monoclonal Antibodies Against Nucleocapsid Protein of Severe Acute Respiratory Syndrome Coronavirus 2 for Coronavirus Disease 2019 Diagnosis. Front Immunol. 2020; 11:595970.
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Biosensing Cytokine IL-6: A Comparative Analysis of Natural and Synthetic Receptors. Biosensors (Basel). 2020 Aug 24; 10(9).