Immunoglobulin Heavy Chains
"Immunoglobulin Heavy Chains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The largest of polypeptide chains comprising immunoglobulins. They contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kDa.
| Descriptor ID |
D007143
|
| MeSH Number(s) |
D12.776.124.486.485.705.500 D12.776.124.790.651.705.500 D12.776.377.715.548.705.500
|
| Concept/Terms |
Immunoglobulin Heavy Chains- Immunoglobulin Heavy Chains
- Heavy Chains, Immunoglobulin
- Ig Heavy Chains
- Heavy Chains, Ig
- Immunoglobulins, Heavy-Chain
- Immunoglobulins, Heavy Chain
- Heavy-Chain Immunoglobulins
- Heavy Chain Immunoglobulins
- Immunoglobulin Heavy Chain
- Heavy Chain, Immunoglobulin
|
Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Heavy Chains".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Heavy Chains".
This graph shows the total number of publications written about "Immunoglobulin Heavy Chains" by people in this website by year, and whether "Immunoglobulin Heavy Chains" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 4 | 5 | 9 |
| 1992 | 6 | 8 | 14 |
| 1993 | 9 | 10 | 19 |
| 1994 | 8 | 10 | 18 |
| 1995 | 14 | 16 | 30 |
| 1996 | 7 | 7 | 14 |
| 1997 | 6 | 11 | 17 |
| 1998 | 6 | 16 | 22 |
| 1999 | 4 | 21 | 25 |
| 2000 | 11 | 16 | 27 |
| 2001 | 14 | 17 | 31 |
| 2002 | 45 | 68 | 113 |
| 2003 | 53 | 58 | 111 |
| 2004 | 52 | 70 | 122 |
| 2005 | 61 | 64 | 125 |
| 2006 | 58 | 63 | 121 |
| 2007 | 52 | 63 | 115 |
| 2008 | 36 | 63 | 99 |
| 2009 | 50 | 72 | 122 |
| 2010 | 40 | 70 | 110 |
| 2011 | 48 | 58 | 106 |
| 2012 | 40 | 76 | 116 |
| 2013 | 52 | 76 | 128 |
| 2014 | 54 | 60 | 114 |
| 2015 | 47 | 81 | 128 |
| 2016 | 51 | 55 | 106 |
| 2017 | 35 | 46 | 81 |
| 2018 | 37 | 46 | 83 |
| 2019 | 10 | 16 | 26 |
| 2020 | 2 | 3 | 5 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Immunoglobulin Heavy Chains" by people in Profiles.
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Stereotypic neutralizing VH antibodies against SARS-CoV-2 spike protein receptor binding domain in patients with COVID-19 and healthy individuals. Sci Transl Med. 2021 01 27; 13(578).
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An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain. Cell Rep. 2020 10 20; 33(3):108274.
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High Potency of a Bivalent Human VH Domain in SARS-CoV-2 Animal Models. Cell. 2020 10 15; 183(2):429-441.e16.
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Structural basis of a shared antibody response to SARS-CoV-2. Science. 2020 08 28; 369(6507):1119-1123.
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Identification of Human Single-Domain Antibodies against SARS-CoV-2. Cell Host Microbe. 2020 06 10; 27(6):891-898.e5.
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Potent neutralization of SARS-CoV-2 by human antibody heavy-chain variable domains isolated from a large library with a new stable scaffold. MAbs. 2020 01 01; 12(1):1778435.
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Characterization of the internal translation initiation region in monoclonal antibodies expressed in Escherichia coli. J Biol Chem. 2019 11 29; 294(48):18046-18056.
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Construction of Anti-hPD-L1 HCAb Nb6 and in Situ124I Labeling for Noninvasive Detection of PD-L1 Expression in Human Bone Sarcoma. Bioconjug Chem. 2019 10 16; 30(10):2614-2623.
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Cutting Edge: Ig H Chains Are Sufficient to Determine Most B Cell Clonal Relationships. J Immunol. 2019 10 01; 203(7):1687-1692.
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High-Throughput Immunogenetics Reveals a Lack of Physiological T Cell Clusters in Patients With Autoimmune Cytopenias. Front Immunol. 2019; 10:1897.