"Khellin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A vasodilator that also has bronchodilatory action. It has been employed in the treatment of angina pectoris, in the treatment of asthma, and in conjunction with ultraviolet light A, has been tried in the treatment of vitiligo. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1024)
| Descriptor ID |
D007666
|
| MeSH Number(s) |
D03.383.663.283.446.794.300 D03.633.100.150.446.794.300 D03.633.300.770.300
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Khellin".
Below are MeSH descriptors whose meaning is more specific than "Khellin".
This graph shows the total number of publications written about "Khellin" by people in this website by year, and whether "Khellin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 2 | 0 | 2 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Khellin" by people in Profiles.
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Visnagin attenuates acute pancreatitis via Nrf2/NF?B pathway and abrogates associated multiple organ dysfunction. Biomed Pharmacother. 2019 Apr; 112:108629.
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Functional nutrition as integrated approach in vitiligo management. Dermatol Ther. 2019 07; 32(4):e12625.
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Highly potent visnagin derivatives inhibit Cyp1 and prevent doxorubicin cardiotoxicity. JCI Insight. 2018 01 11; 3(1).
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Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase. Sci Transl Med. 2014 Dec 10; 6(266):266ra170.
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Khellin and visnagin differentially modulate AHR signaling and downstream CYP1A activity in human liver cells. PLoS One. 2013; 8(9):e74917.
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Pharmacokinetic evaluation of visnagin and Ammi visnaga aqueous extract after oral administration in rats. Planta Med. 2012 Nov; 78(17):1831-6.
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Molecular modeling study bioactive natural product of khellin analogues as a novel potential pharmacophore of EGFR inhibitors. J Enzyme Inhib Med Chem. 2013 Dec; 28(6):1171-81.
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Nonlinear pharmacokinetics of visnagin in rats after intravenous bolus administration. Eur J Pharm Sci. 2012 Jan 23; 45(1-2):79-89.
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Determination of visnagin in rat plasma by liquid chromatography with tandem mass spectrometry and its application to in vivo pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Mar 01; 877(7):653-6.
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Vitiligo: phototherapeutic options. J Am Acad Dermatol. 1999 Apr; 40(4):645.