"Silymarin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mixture of flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum. It consists primarily of silybin and its isomers, silicristin and silidianin. Silymarin displays antioxidant and membrane stabilizing activity. It protects various tissues and organs against chemical injury, and shows potential as an antihepatoxic agent.
| Descriptor ID |
D012838
|
| MeSH Number(s) |
D03.383.663.283.266.450.268.777 D03.633.100.150.266.450.268.777
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Silymarin".
Below are MeSH descriptors whose meaning is more specific than "Silymarin".
This graph shows the total number of publications written about "Silymarin" by people in this website by year, and whether "Silymarin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 2 | 0 | 2 |
| 1997 | 2 | 0 | 2 |
| 2001 | 3 | 0 | 3 |
| 2002 | 4 | 4 | 8 |
| 2003 | 5 | 1 | 6 |
| 2004 | 4 | 0 | 4 |
| 2005 | 2 | 7 | 9 |
| 2006 | 8 | 10 | 18 |
| 2007 | 5 | 12 | 17 |
| 2008 | 7 | 6 | 13 |
| 2009 | 13 | 16 | 29 |
| 2010 | 23 | 10 | 33 |
| 2011 | 35 | 5 | 40 |
| 2012 | 41 | 5 | 46 |
| 2013 | 40 | 4 | 44 |
| 2014 | 28 | 10 | 38 |
| 2015 | 38 | 10 | 48 |
| 2016 | 28 | 6 | 34 |
| 2017 | 47 | 17 | 64 |
| 2018 | 24 | 7 | 31 |
| 2019 | 10 | 4 | 14 |
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Below are the most recent publications written about "Silymarin" by people in Profiles.
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Protective effects of curcumin and silymarin against paracetamol induced hepatotoxicity in adult male albino rats. Gene. 2019 Sep 05; 712:143966.
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Hepatoprotective efficacy of Premna integrifolia L. leaves against aflatoxin B1-induced toxicity in mice. Toxicon. 2019 Aug; 166:88-100.
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Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. Phytother Res. 2019 Jun; 33(6):1627-1638.
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Treatment options for nonalcoholic fatty liver disease: a double-blinded randomized placebo-controlled trial. Eur J Gastroenterol Hepatol. 2019 05; 31(5):613-617.
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Effects of silymarin on p65 NF-?B, p38 MAPK and CYP450 in LPS-induced hoof dermal inflammatory cells of dairy cows. BMC Vet Res. 2019 Apr 30; 15(1):127.
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Formulation of Nanomicelles to Improve the Solubility and the Oral Absorption of Silymarin. Molecules. 2019 Apr 30; 24(9).
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Silibinin inhibits in vitro ketosis by regulating HMGCS2 and NF-kB: elucidation of signaling molecule relationship under ketotic conditions. In Vitro Cell Dev Biol Anim. 2019 May; 55(5):368-375.
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Tyrosinase inhibitory study of flavonolignans from the seeds of Silybum marianum (Milk thistle). Bioorg Med Chem. 2019 06 15; 27(12):2499-2507.
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Effects of silymarin supplementation on blood lipids: A systematic review and meta-analysis of clinical trials. Phytother Res. 2019 Apr; 33(4):871-880.
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Dextrose modified bilosomes for peroral delivery: improved therapeutic potential and stability of silymarin in diethylnitrosamine-induced hepatic carcinoma in rats. J Liposome Res. 2019 Sep; 29(3):251-263.