"Silymarin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mixture of flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum. It consists primarily of silybin and its isomers, silicristin and silidianin. Silymarin displays antioxidant and membrane stabilizing activity. It protects various tissues and organs against chemical injury, and shows potential as an antihepatoxic agent.
| Descriptor ID |
D012838
|
| MeSH Number(s) |
D03.383.663.283.266.450.268.777 D03.633.100.150.266.450.268.777
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Silymarin".
Below are MeSH descriptors whose meaning is more specific than "Silymarin".
This graph shows the total number of publications written about "Silymarin" by people in this website by year, and whether "Silymarin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 3 | 0 | 3 |
| 1997 | 1 | 0 | 1 |
| 1999 | 1 | 0 | 1 |
| 2001 | 2 | 0 | 2 |
| 2002 | 4 | 1 | 5 |
| 2003 | 3 | 0 | 3 |
| 2004 | 3 | 0 | 3 |
| 2005 | 1 | 3 | 4 |
| 2006 | 5 | 6 | 11 |
| 2007 | 5 | 6 | 11 |
| 2008 | 6 | 4 | 10 |
| 2009 | 11 | 7 | 18 |
| 2010 | 11 | 5 | 16 |
| 2011 | 19 | 3 | 22 |
| 2012 | 19 | 3 | 22 |
| 2013 | 22 | 1 | 23 |
| 2014 | 14 | 7 | 21 |
| 2015 | 18 | 7 | 25 |
| 2016 | 19 | 4 | 23 |
| 2017 | 27 | 9 | 36 |
| 2018 | 17 | 6 | 23 |
| 2019 | 6 | 1 | 7 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Silymarin" by people in Profiles.
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Phyto-pharmacological perspective of Silymarin: A potential prophylactic or therapeutic agent for COVID-19, based on its promising immunomodulatory, anti-coagulant and anti-viral property. Phytother Res. 2021 Aug; 35(8):4246-4257.
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SARS-CoV-2 Main Protease Active Site Ligands in the Human Metabolome. Molecules. 2021 Mar 05; 26(5).
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Silymarin Enriched Extract (Silybum marianum) Additive Effect on Doxorubicin-Mediated Cytotoxicity in PC-3 Prostate Cancer Cells. Planta Med. 2019 Aug; 85(11-12):997-1007.
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Protective effects of curcumin and silymarin against paracetamol induced hepatotoxicity in adult male albino rats. Gene. 2019 Sep 05; 712:143966.
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Hepatoprotective efficacy of Premna integrifolia L. leaves against aflatoxin B1-induced toxicity in mice. Toxicon. 2019 Aug; 166:88-100.
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Treatment options for nonalcoholic fatty liver disease: a double-blinded randomized placebo-controlled trial. Eur J Gastroenterol Hepatol. 2019 05; 31(5):613-617.
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Immunoregulatory Effects of Silymarin on Proliferation and Activation of Th1 Cells Isolated from Newly Diagnosed and IFN-ß1b-Treated MS Patients. Inflammation. 2019 Feb; 42(1):54-63.
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Beneficial Effect of Silymarin in Pressure Overload Induced Experimental Cardiac Hypertrophy. Cardiovasc Toxicol. 2019 02; 19(1):23-35.
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Metabolic effect of berberine-silymarin association: A meta-analysis of randomized, double-blind, placebo-controlled clinical trials. Phytother Res. 2019 Apr; 33(4):862-870.
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Evaluation of silymarin/duck's feet-derived collagen/hydroxyapatite sponges for bone tissue regeneration. Mater Sci Eng C Mater Biol Appl. 2019 Apr; 97:347-355.