"Thioacetazone" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A thiosemicarbazone that is used in association with other antimycobacterial agents in the initial and continuation phases of antituberculosis regimens. Thiacetazone containing regimens are less effective than the short-course regimen recommended by the International Union Against Tuberculosis and are used in some developing countries to reduce drug costs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p217)
| Descriptor ID |
D013828
|
| MeSH Number(s) |
D02.845.746.703.702 D02.886.803.702
|
| Concept/Terms |
TB I-698- TB I-698
- TB I 698
- TB I698
- TBI-698
- TBI 698
- TBI698
|
Below are MeSH descriptors whose meaning is more general than "Thioacetazone".
Below are MeSH descriptors whose meaning is more specific than "Thioacetazone".
This graph shows the total number of publications written about "Thioacetazone" by people in this website by year, and whether "Thioacetazone" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 1 | 0 | 1 |
| 1993 | 1 | 1 | 2 |
| 1997 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 1 | 2 |
| 2009 | 1 | 0 | 1 |
| 2012 | 2 | 0 | 2 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 1 | 1 | 2 |
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Below are the most recent publications written about "Thioacetazone" by people in Profiles.
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Resistance to Thiacetazone Derivatives Active against Mycobacterium abscessus Involves Mutations in the MmpL5 Transcriptional Repressor MAB_4384. Antimicrob Agents Chemother. 2017 04; 61(4).
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Group 5 drugs for multidrug-resistant tuberculosis: individual patient data meta-analysis. Eur Respir J. 2017 01; 49(1).
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A new dehydratase conferring innate resistance to thiacetazone and intra-amoebal survival of Mycobacterium smegmatis. Mol Microbiol. 2015 Jun; 96(5):1085-102.
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Pharmacovigilance and tuberculosis: applying the lessons of thioacetazone. Bull World Health Organ. 2014 Dec 01; 92(12):918-9.
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Synthesis, antitubercular activity and mechanism of resistance of highly effective thiacetazone analogues. PLoS One. 2013; 8(1):e53162.
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A common mechanism of inhibition of the Mycobacterium tuberculosis mycolic acid biosynthetic pathway by isoxyl and thiacetazone. J Biol Chem. 2012 Nov 09; 287(46):38434-41.
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Exposure of mycobacteria to cell wall-inhibitory drugs decreases production of arabinoglycerolipid related to Mycolyl-arabinogalactan-peptidoglycan metabolism. J Biol Chem. 2012 Mar 30; 287(14):11060-9.
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Mycolic acid methyltransferase, MmaA4, is necessary for thiacetazone susceptibility in Mycobacterium tuberculosis. Mol Microbiol. 2009 Mar; 71(5):1263-77.
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Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria. PLoS One. 2007 Dec 19; 2(12):e1343.
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EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets. Antimicrob Agents Chemother. 2007 Mar; 51(3):1055-63.