"Enzyme Reactivators" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Compounds which restore enzymatic activity by removing an inhibitory group bound to the reactive site of the enzyme.
| Descriptor ID |
D004793
|
| MeSH Number(s) |
D27.505.519.405
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Enzyme Reactivators".
Below are MeSH descriptors whose meaning is more specific than "Enzyme Reactivators".
This graph shows the total number of publications written about "Enzyme Reactivators" by people in this website by year, and whether "Enzyme Reactivators" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1995 | 1 | 1 | 2 |
| 1996 | 2 | 0 | 2 |
| 1997 | 1 | 1 | 2 |
| 2002 | 1 | 2 | 3 |
| 2003 | 2 | 1 | 3 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 3 | 3 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
| 2008 | 3 | 0 | 3 |
| 2009 | 1 | 1 | 2 |
| 2010 | 2 | 1 | 3 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 2 | 0 | 2 |
| 2015 | 2 | 0 | 2 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Enzyme Reactivators" by people in Profiles.
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In Vitro Evaluation of Neutral Aryloximes as Reactivators for Electrophorus eel Acetylcholinesterase Inhibited by Paraoxon. Biomolecules. 2019 10 08; 9(10).
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Alcohol Metabolic Inefficiency: Structural Characterization of Polymorphism-Induced ALDH2 Dysfunctionality and Allosteric Site Identification for Design of Potential Wildtype Reactivators. Protein J. 2018 06; 37(3):216-222.
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In silico studies on the role of mutant Y337A to reactivate tabun inhibited mAChE with K048. Chem Biol Interact. 2015 Dec 05; 242:299-306.
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Development of surface modified biodegradable polymeric nanoparticles to deliver GSE24.2 peptide to cells: a promising approach for the treatment of defective telomerase disorders. Eur J Pharm Biopharm. 2015 Apr; 91:91-102.
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Reactivation of plasma butyrylcholinesterase by pralidoxime chloride in patients poisoned by WHO class II toxicity organophosphorus insecticides. Toxicol Sci. 2014 Apr; 138(2):482.
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Plasma butyrylcholinesterase as a marker of clinical outcome in diethyl organophosphorus insecticide poisoned patients treated with pralidoxime. Toxicol Sci. 2014 Apr; 138(2):483-4.
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Reactivation of plasma butyrylcholinesterase by pralidoxime chloride in patients poisoned by WHO class II toxicity organophosphorus insecticides. Toxicol Sci. 2013 Dec; 136(2):274-83.
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Reactivating PP2A by FTY720 as a novel therapy for AML with C-KIT tyrosine kinase domain mutation. J Cell Biochem. 2012 Apr; 113(4):1314-22.
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Amidine-oximes: reactivators for organophosphate exposure. J Med Chem. 2011 May 12; 54(9):3319-30.
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Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature. 2011 Jan 06; 469(7328):102-6.