"Amitriptyline" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
| Descriptor ID |
D000639
|
| MeSH Number(s) |
D02.455.426.559.847.181.384.100 D04.615.181.384.100
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Amitriptyline".
Below are MeSH descriptors whose meaning is more specific than "Amitriptyline".
This graph shows the total number of publications written about "Amitriptyline" by people in this website by year, and whether "Amitriptyline" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 0 | 1 | 1 |
| 1994 | 2 | 0 | 2 |
| 1995 | 3 | 1 | 4 |
| 1996 | 1 | 0 | 1 |
| 1997 | 2 | 0 | 2 |
| 1998 | 0 | 1 | 1 |
| 1999 | 2 | 0 | 2 |
| 2000 | 4 | 1 | 5 |
| 2001 | 2 | 1 | 3 |
| 2002 | 6 | 1 | 7 |
| 2003 | 2 | 4 | 6 |
| 2004 | 6 | 3 | 9 |
| 2005 | 8 | 5 | 13 |
| 2006 | 5 | 7 | 12 |
| 2007 | 7 | 5 | 12 |
| 2008 | 6 | 1 | 7 |
| 2009 | 9 | 11 | 20 |
| 2010 | 6 | 6 | 12 |
| 2011 | 10 | 5 | 15 |
| 2012 | 5 | 10 | 15 |
| 2013 | 14 | 8 | 22 |
| 2014 | 5 | 10 | 15 |
| 2015 | 8 | 4 | 12 |
| 2016 | 12 | 8 | 20 |
| 2017 | 15 | 7 | 22 |
| 2018 | 7 | 3 | 10 |
| 2019 | 5 | 0 | 5 |
To return to the timeline, click here.
Below are the most recent publications written about "Amitriptyline" by people in Profiles.
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Transfer of Cyclobenzaprine into Human Milk and Subsequent Infant Exposure. J Hum Lact. 2019 Aug; 35(3):559-562.
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Amitriptyline Treatment Mitigates Sepsis-Induced Tumor Necrosis Factor Expression and Coagulopathy. Shock. 2019 03; 51(3):356-363.
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Multi-Spectroscopic Characterization of Human Serum Albumin Binding with Cyclobenzaprine Hydrochloride: Insights from Biophysical and In Silico Approaches. Int J Mol Sci. 2019 Feb 03; 20(3).
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High concentration of topical amitriptyline for treating chemotherapy-induced neuropathies. Support Care Cancer. 2019 Aug; 27(8):3053-3059.
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Amitriptyline Reduces Inflammation and Mortality in a Murine Model of Sepsis. Cell Physiol Biochem. 2019; 52(3):565-579.
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Drug-induced Creutzfeldt-Jakob disease-like syndrome: early CSF analysis as useful tool for differential diagnosis. BMJ Case Rep. 2018 Dec 04; 11(1).
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Efficacy of Low-Dose Amitriptyline for Chronic Low Back Pain: A Randomized Clinical Trial. JAMA Intern Med. 2018 11 01; 178(11):1474-1481.
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Tranylcypromine Plus Amitriptyline for Electroconvulsive Therapy-Resistant Depression: A Long-Term Study. J Clin Psychopharmacol. 2018 Oct; 38(5):502-504.
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Trends and Patterns of Antidepressant Use in French Children and Adolescents From 2009 to 2016: A Population-Based Study in the French Health Insurance Database. J Clin Psychopharmacol. 2018 Aug; 38(4):327-335.
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The Changing Landscape of Pediatric Migraine Therapy: A Review. JAMA Neurol. 2018 07 01; 75(7):881-887.