Orotate Phosphoribosyltransferase
"Orotate Phosphoribosyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The enzyme catalyzing the formation of orotidine-5'-phosphoric acid (orotidylic acid) from orotic acid and 5-phosphoribosyl-1-pyrophosphate in the course of pyrimidine nucleotide biosynthesis. EC 2.4.2.10.
| Descriptor ID |
D009962
|
| MeSH Number(s) |
D08.811.913.400.725.700
|
| Concept/Terms |
Orotate Phosphoribosyltransferase- Orotate Phosphoribosyltransferase
- Phosphoribosyltransferase, Orotate
- Orotidylic Acid Phosphorylase
- Phosphorylase, Orotidylic Acid
- Orotidine-5'-Phosphate Pyrophosphorylase
- Orotidine 5' Phosphate Pyrophosphorylase
- Pyrophosphorylase, Orotidine-5'-Phosphate
- OMPase
- Orotidine-5'-Monophosphate Phosphohydrolase
- Orotidine 5' Monophosphate Phosphohydrolase
- Phosphohydrolase, Orotidine-5'-Monophosphate
|
Below are MeSH descriptors whose meaning is more general than "Orotate Phosphoribosyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Orotate Phosphoribosyltransferase".
This graph shows the total number of publications written about "Orotate Phosphoribosyltransferase" by people in this website by year, and whether "Orotate Phosphoribosyltransferase" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 |
| 2000 | 2 | 0 | 2 |
| 2002 | 0 | 1 | 1 |
| 2003 | 2 | 1 | 3 |
| 2004 | 4 | 2 | 6 |
| 2005 | 3 | 2 | 5 |
| 2006 | 5 | 3 | 8 |
| 2007 | 3 | 0 | 3 |
| 2009 | 0 | 3 | 3 |
| 2010 | 2 | 3 | 5 |
| 2011 | 2 | 3 | 5 |
| 2012 | 3 | 3 | 6 |
| 2013 | 0 | 1 | 1 |
| 2014 | 2 | 1 | 3 |
| 2015 | 2 | 0 | 2 |
| 2016 | 3 | 2 | 5 |
| 2017 | 4 | 1 | 5 |
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Below are the most recent publications written about "Orotate Phosphoribosyltransferase" by people in Profiles.
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Orotate phosphoribosyltransferase as a predictor of benefit from S-1 adjuvant chemotherapy for cholangiocarcinoma patients. J Gastroenterol Hepatol. 2019 Jun; 34(6):1108-1115.
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Conditional disruption of hepatic carbamoyl phosphate synthetase 1 in mice results in hyperammonemia without orotic aciduria and can be corrected by liver-directed gene therapy. Mol Genet Metab. 2018 08; 124(4):243-253.
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Development of new promising antimetabolite, DFP-11207 with self-controlled toxicity in rodents. Drug Des Devel Ther. 2017; 11:1693-1705.
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Uridine monophosphate synthetase enables eukaryotic de novo NAD+ biosynthesis from quinolinic acid. J Biol Chem. 2017 07 07; 292(27):11147-11153.
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Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase. Cell. 2017 Apr 06; 169(2):258-272.e17.
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Bifunctional activity of fused Plasmodium falciparum orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase. Parasitol Int. 2018 Feb; 67(1):79-84.
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A phase II study of preoperative chemoradiation with tegafur-uracil plus leucovorin for locally advanced rectal cancer with pharmacogenetic analysis. Radiat Oncol. 2017 Mar 27; 12(1):62.
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Mild orotic aciduria in UMPS heterozygotes: a metabolic finding without clinical consequences. J Inherit Metab Dis. 2017 05; 40(3):423-431.
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Development of a pyrE-based selective system for Thermotoga sp. strain RQ7. Extremophiles. 2017 Mar; 21(2):297-306.
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Phase II trial of S-1 plus leucovorin in patients with advanced gastric cancer and clinical prediction by S-1 pharmacogenetic pathway. Cancer Chemother Pharmacol. 2017 Jan; 79(1):69-79.