Suppressor of Cytokine Signaling 3 Protein

"Suppressor of Cytokine Signaling 3 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.
MeSH information
A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS3 inhibits cytokine signaling by binding to RECEPTOR PROTEIN-TYROSINE KINASES as well as CYTOKINE RECEPTOR GP130; ERYTHROPOIETIN RECEPTORS; INSULIN RECEPTOR; and the LEPTIN RECEPTOR. Its functions include suppression of ERYTHROPOIESIS in the fetal liver.


Publications
This graph shows the total number of publications written about "Suppressor of Cytokine Signaling 3 Protein" by people in this website by year, and whether "Suppressor of Cytokine Signaling 3 Protein" was a major or minor topic of these publications.
Bar chart showing 787 publications over 22 distinct years, with a maximum of 66 publications in 2012
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