Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
"Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transcriptional co-activator for NUCLEAR RECEPTORS. It is characterized by an N-terminal LxxLL sequence, a region that interacts with PPAR GAMMA, and a C-terminal RNA RECOGNITION MOTIF. It increases expression of MITOCHONDRIAL UNCOUPLING PROTEIN to regulate genes involved in metabolic reprogramming in response to dietary restriction and the integration of CIRCADIAN RHYTHMS with ENERGY METABOLISM.
| Descriptor ID |
D000071248
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| MeSH Number(s) |
D12.644.360.024.314.650 D12.776.157.057.080.650 D12.776.157.725.813.875 D12.776.476.024.394.650 D12.776.660.675.650 D12.776.664.962.813.875 D12.776.930.617.650
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha".
Below are MeSH descriptors whose meaning is more specific than "Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha".
This graph shows the total number of publications written about "Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha" by people in this website by year, and whether "Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2004 | 0 | 9 | 9 |
| 2005 | 0 | 21 | 21 |
| 2006 | 0 | 24 | 24 |
| 2007 | 0 | 36 | 36 |
| 2008 | 0 | 43 | 43 |
| 2009 | 0 | 65 | 65 |
| 2010 | 0 | 70 | 70 |
| 2011 | 0 | 82 | 82 |
| 2012 | 0 | 113 | 113 |
| 2013 | 1 | 116 | 117 |
| 2014 | 0 | 113 | 113 |
| 2015 | 2 | 103 | 105 |
| 2016 | 61 | 84 | 145 |
| 2017 | 59 | 85 | 144 |
| 2018 | 74 | 68 | 142 |
| 2019 | 23 | 31 | 54 |
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Below are the most recent publications written about "Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha" by people in Profiles.
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Bronchial thermoplasty decreases airway remodelling by blocking epithelium-derived heat shock protein-60 secretion and protein arginine methyltransferase-1 in fibroblasts. Eur Respir J. 2019 12; 54(6).
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Prep1 regulates angiogenesis through a PGC-1a-mediated mechanism. FASEB J. 2019 12; 33(12):13893-13904.
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Cardiomyocyte-specific loss of RNA polymerase II subunit 5-mediating protein causes myocardial dysfunction and heart failure. Cardiovasc Res. 2019 Sep 01; 115(11):1617-1628.
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Mechanisms of exercise-induced survival motor neuron expression in the skeletal muscle of spinal muscular atrophy-like mice. J Physiol. 2019 09; 597(18):4757-4778.
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Fine-Tuning of PGC1a Expression Regulates Cardiac Function and Longevity. Circ Res. 2019 09 13; 125(7):707-719.
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Dual peroxisome-proliferator-activated-receptor-a/? activation inhibits SIRT1-PGC1a axis and causes cardiac dysfunction. JCI Insight. 2019 08 08; 5.
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Tetrahydrobiopterin enhances mitochondrial biogenesis and cardiac contractility via stimulation of PGC1a signaling. Biochim Biophys Acta Mol Basis Dis. 2019 11 01; 1865(11):165524.
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Promotion of Mitochondrial Biogenesis via Activation of AMPK-PGC1? Signaling Pathway by Ginger (Zingiber officinale Roscoe) Extract, and Its Major Active Component 6-Gingerol. J Food Sci. 2019 Aug; 84(8):2101-2111.
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Butyrate promotes slow-twitch myofiber formation and mitochondrial biogenesis in finishing pigs via inducing specific microRNAs and PGC-1a expression1. J Anim Sci. 2019 Jul 30; 97(8):3180-3192.
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[Effect of electroacupuncture combined with treadmill exercise on body weight and expression of PGC-1a, Irisin and AMPK in skeletal muscle of diet-induced obesity rats]. Zhen Ci Yan Jiu. 2019 Jul 25; 44(7):476-80.