Alpha-Ketoglutarate-Dependent Dioxygenase FTO
"Alpha-Ketoglutarate-Dependent Dioxygenase FTO" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. It has highest activity towards single-stranded RNA containing 3-methyluracil, followed by SINGLE-STRANDED DNA containing 3-methylthymine and specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA (mRNA) in higher EUKARYOTES. It contributes to the regulation of the global metabolic rate, energy HOMEOSTASIS, as well as body fat accumulation by regulating the differentiation of ADIPOCYTES into BROWN FAT CELLS or WHITE FAT CELLS.
| Descriptor ID |
D000071516
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| MeSH Number(s) |
D08.811.074.062.968 D08.811.682.662.582.242 D08.811.682.690.416.139.992
|
| Concept/Terms |
Alpha-Ketoglutarate-Dependent Dioxygenase FTO- Alpha-Ketoglutarate-Dependent Dioxygenase FTO
- Alpha Ketoglutarate Dependent Dioxygenase FTO
- FTO, Alpha-Ketoglutarate-Dependent Dioxygenase
- Fat Mass and Obesity Associated (FTO) Protein
- Alpha-Ketoglutarate-Dependent Dioxygenase
- Alpha Ketoglutarate Dependent Dioxygenase
- Dioxygenase, Alpha-Ketoglutarate-Dependent
- Fat Mass and Obesity Associated Protein
- AlkB Homolog 9 Protein
|
Below are MeSH descriptors whose meaning is more general than "Alpha-Ketoglutarate-Dependent Dioxygenase FTO".
Below are MeSH descriptors whose meaning is more specific than "Alpha-Ketoglutarate-Dependent Dioxygenase FTO".
This graph shows the total number of publications written about "Alpha-Ketoglutarate-Dependent Dioxygenase FTO" by people in this website by year, and whether "Alpha-Ketoglutarate-Dependent Dioxygenase FTO" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 1 | 1 |
| 2017 | 2 | 1 | 3 |
| 2018 | 5 | 0 | 5 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Alpha-Ketoglutarate-Dependent Dioxygenase FTO" by people in Profiles.
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Methyltransferase-like 3 Modulates Severe Acute Respiratory Syndrome Coronavirus-2 RNA N6-Methyladenosine Modification and Replication. mBio. 2021 08 31; 12(4):e0106721.
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The Influence of FTO Polymorphism rs9939609 on Obesity, Some Clinical Features, and Disturbance of Carbohydrate Metabolism in Patients with Psoriasis. Biomed Res Int. 2019; 2019:7304345.
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Influence of FTO rs9939609 and Mediterranean diet on body composition and weight loss: a randomized clinical trial. J Transl Med. 2018 11 12; 16(1):308.
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Associations between obesity candidate gene polymorphisms (fat mass and obesity-associated (FTO), melanocortin-4 receptor (MC4R), leptin (LEP) and leptin receptor (LEPR)) and dietary intake in pregnant women. Br J Nutr. 2018 08; 120(4):454-463.
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Association of FTO rs9939609 with Obesity. Med Princ Pract. 2018; 27(5):496.
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Increased N6-methyladenosine causes infertility is associated with FTO expression. J Cell Physiol. 2018 09; 233(9):7055-7066.
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Breastfeeding moderates FTO related adiposity: a birth cohort study with 30 years of follow-up. Sci Rep. 2018 02 07; 8(1):2530.
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Excessive fuel availability amplifies the FTO-mediated obesity risk: results from the TUEF and Whitehall II studies. Sci Rep. 2017 11 14; 7(1):15486.
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Meta-analysis of gene-environment interaction exploiting gene-environment independence across multiple case-control studies. Stat Med. 2017 Oct 30; 36(24):3895-3909.
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Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis. Hum Mol Genet. 2017 07 01; 26(13):2398-2411.