Interferon-Induced Helicase, IFIH1
"Interferon-Induced Helicase, IFIH1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DEAD box RNA helicase that contains two N-terminal CASPASE ACTIVATION AND RECRUITMENT DOMAINS. It functions as a sensor of viral NUCLEIC ACIDS such as DOUBLE-STRANDED RNA and activates the INNATE IMMUNE RESPONSE by inducing the expression of INTERFERON-ALPHA and INTERFERON-BETA. It may also regulate cell growth and APOPTOSIS.
Descriptor ID |
D000072640
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MeSH Number(s) |
D08.811.913.696.445.735.720.249.875
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Concept/Terms |
Interferon-Induced Helicase, IFIH1- Interferon-Induced Helicase, IFIH1
- Helicase, IFIH1 Interferon-Induced
- IFIH1 Interferon-Induced Helicase
- Interferon Induced Helicase, IFIH1
- Helicard
- Melanoma Differentiation-Associated Protein 5
- Melanoma Differentiation Associated Protein 5
- CADM-140 Autoantigen
- Autoantigen, CADM-140
- CADM 140 Autoantigen
- Interferon Induced with Helicase C Domain 1
- Interferon-Induced Helicase C Domain-Containing Protein 1
- Interferon Induced Helicase C Domain Containing Protein 1
- IFIH1 Protein
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Below are MeSH descriptors whose meaning is more general than "Interferon-Induced Helicase, IFIH1".
Below are MeSH descriptors whose meaning is more specific than "Interferon-Induced Helicase, IFIH1".
This graph shows the total number of publications written about "Interferon-Induced Helicase, IFIH1" by people in this website by year, and whether "Interferon-Induced Helicase, IFIH1" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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2006 | 0 | 1 | 1 |
2008 | 0 | 1 | 1 |
2011 | 0 | 2 | 2 |
2012 | 0 | 1 | 1 |
2014 | 0 | 2 | 2 |
2015 | 0 | 2 | 2 |
2016 | 1 | 1 | 2 |
2017 | 6 | 4 | 10 |
2018 | 6 | 1 | 7 |
2019 | 0 | 4 | 4 |
2020 | 1 | 0 | 1 |
2021 | 2 | 6 | 8 |
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Below are the most recent publications written about "Interferon-Induced Helicase, IFIH1" by people in Profiles.
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COVID-19 and Myositis: What We Know So Far. Curr Rheumatol Rep. 2021 07 03; 23(8):63.
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SARS-CoV-2 sensing by RIG-I and MDA5 links epithelial infection to macrophage inflammation. EMBO J. 2021 08 02; 40(15):e107826.
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The RNA sensor MDA5 detects SARS-CoV-2 infection. Sci Rep. 2021 07 01; 11(1):13638.
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RIG-I-Like Receptor-Mediated Recognition of Viral Genomic RNA of Severe Acute Respiratory Syndrome Coronavirus-2 and Viral Escape From the Host Innate Immune Responses. Front Immunol. 2021; 12:700926.
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Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell. Cell Rep. 2021 07 13; 36(2):109364.
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Opposing forces fight over the same ground to regulate interferon signaling. Biochem J. 2021 05 28; 478(10):1853-1859.
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SARS-CoV-2 Membrane Protein Inhibits Type I Interferon Production Through Ubiquitin-Mediated Degradation of TBK1. Front Immunol. 2021; 12:662989.
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SARS-CoV-2 ORF9b antagonizes type I and III interferons by targeting multiple components of the RIG-I/MDA-5-MAVS, TLR3-TRIF, and cGAS-STING signaling pathways. J Med Virol. 2021 09; 93(9):5376-5389.
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COVID-19 shares clinical features with anti-melanoma differentiation-associated protein 5 positive dermatomyositis and adult Still's disease. Clin Exp Rheumatol. 2021 May-Jun; 39(3):631-638.
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Understanding and managing anti-MDA 5 dermatomyositis, including potential COVID-19 mimicry. Rheumatol Int. 2021 06; 41(6):1021-1036.