"Pemetrexed" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A guanine-derived ANTINEOPLASTIC AGENT that functions as a NUCLEIC ACID SYNTHESIS INHIBITOR through its binding to, and inhibition of, THYMIDYLATE SYNTHASE.
| Descriptor ID |
D000068437
|
| MeSH Number(s) |
D03.633.100.759.758.399.454.650 D12.125.067.625.525 D12.125.119.409.525
|
| Concept/Terms |
Pemetrexed- Pemetrexed
- MTA
- N-(4-(2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo(2,3-d)pyrimdin-5-yl)ethyl)benzoyl)glutamic acid
LY 231514- LY 231514
- 231514, LY
- LY-231,514
- LY231514
- LY 231,514
- 231,514, LY
- LY-231514
|
Below are MeSH descriptors whose meaning is more general than "Pemetrexed".
Below are MeSH descriptors whose meaning is more specific than "Pemetrexed".
This graph shows the total number of publications written about "Pemetrexed" by people in this website by year, and whether "Pemetrexed" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 0 | 1 | 1 |
| 2017 | 6 | 5 | 11 |
| 2018 | 5 | 6 | 11 |
| 2019 | 1 | 2 | 3 |
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Below are the most recent publications written about "Pemetrexed" by people in Profiles.
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Prioritizing potential ACE2 inhibitors in the COVID-19 pandemic: Insights from a molecular mechanics-assisted structure-based virtual screening experiment. J Mol Graph Model. 2020 11; 100:107697.
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2-Deoxy-glucose Enhances the Effect of Cisplatin and Pemetrexed in Reducing Malignant Pleural Mesothelioma Cell Proliferation But Not Spheroid Growth. Anticancer Res. 2019 Jul; 39(7):3809-3814.
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Association between certain non-small cell lung cancer driver mutations and predictive markers for chemotherapy or programmed death-ligand 1 inhibition. Cancer Sci. 2019 Jun; 110(6):2014-2021.
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Opposite effects of Vaccinia and modified Vaccinia Ankara on trained immunity. Eur J Clin Microbiol Infect Dis. 2019 Mar; 38(3):449-456.
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Exploiting FAsting-mimicking Diet and MEtformin to Improve the Efficacy of Platinum-pemetrexed Chemotherapy in Advanced LKB1-inactivated Lung Adenocarcinoma: The FAME Trial. Clin Lung Cancer. 2019 05; 20(3):e413-e417.
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Novel anticancers and dermatological adversities: old rivals but new challenges. BMJ Case Rep. 2018 Dec 14; 11(1).
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The evolving role of pemetrexed disodium for the treatment of non-small cell lung cancer. Expert Opin Pharmacother. 2018 Dec; 19(17):1969-1976.
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CNS Efficacy of Osimertinib in Patients With T790M-Positive Advanced Non-Small-Cell Lung Cancer: Data From a Randomized Phase III Trial (AURA3). J Clin Oncol. 2018 09 10; 36(26):2702-2709.
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Cisplatin-Based First-Line Treatment of Elderly Patients With Advanced Non-Small-Cell Lung Cancer: Joint Analysis of MILES-3 and MILES-4 Phase III Trials. J Clin Oncol. 2018 09 01; 36(25):2585-2592.
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Pemetrexed Continuation Maintenance Phase 3 Trials in Nonsquamous, Non-Small-Cell Lung Cancer: Focus on 2-Year Overall Survival and Continuum of Care. Clin Lung Cancer. 2018 11; 19(6):e823-e830.