"Cholera Toxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells, and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
| Descriptor ID |
D002772
|
| MeSH Number(s) |
D08.811.913.400.725.115.180 D23.946.123.194 D23.946.330.150
|
| Concept/Terms |
Cholera Toxin- Cholera Toxin
- Toxin, Cholera
- Cholera Exotoxin
- Exotoxin, Cholera
- Choleragen
- Cholera Enterotoxin CT
- CT, Cholera Enterotoxin
- Enterotoxin CT, Cholera
Choleragenoid- Choleragenoid
- Cholera Toxin Protomer B
- Cholera Toxin B Subunit
|
Below are MeSH descriptors whose meaning is more general than "Cholera Toxin".
Below are MeSH descriptors whose meaning is more specific than "Cholera Toxin".
This graph shows the total number of publications written about "Cholera Toxin" by people in this website by year, and whether "Cholera Toxin" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 2 | 0 | 2 |
| 2017 | 2 | 7 | 9 |
| 2018 | 0 | 3 | 3 |
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Below are the most recent publications written about "Cholera Toxin" by people in Profiles.
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Microbial patterns in patients with histamine intolerance. J Physiol Pharmacol. 2018 Aug; 69(4).
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Letter to the Editor regarding Mörkl et al.'s paper: Gut microbiota, dietary intakes and intestinal permeability reflected by serum zonulin in women. Eur J Nutr. 2018 12; 57(8):2999-3000.
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Increased jejunal permeability in human obesity is revealed by a lipid challenge and is linked to inflammation and type 2 diabetes. J Pathol. 2018 10; 246(2):217-230.
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Assessing antigen specific HLA-DR+ antibody secreting cell (DR+ASC) responses in whole blood in enteric infections using an ELISPOT technique. Microbes Infect. 2018 02; 20(2):122-129.
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Yeast-expressed recombinant As16 protects mice against Ascaris suum infection through induction of a Th2-skewed immune response. PLoS Negl Trop Dis. 2017 Jul; 11(7):e0005769.
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Plasma and Mucosal Immunoglobulin M, Immunoglobulin A, and Immunoglobulin G Responses to the Vibrio cholerae O1 Protein Immunome in Adults With Cholera in Bangladesh. J Infect Dis. 2017 07 01; 216(1):125-134.
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Low-grade endotoxemia, gut permeability and platelet activation in patients with impaired fasting glucose. Nutr Metab Cardiovasc Dis. 2017 Oct; 27(10):890-895.
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Serum Zonulin, Gut Permeability, and the Pathogenesis of Autism Spectrum Disorders: Cause, Effect, or an Epiphenomenon? J Pediatr. 2017 09; 188:15-17.
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Zonulin transgenic mice show altered gut permeability and increased morbidity/mortality in the DSS colitis model. Ann N Y Acad Sci. 2017 06; 1397(1):130-142.
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Replication of Vibrio cholerae classical CTX phage. Proc Natl Acad Sci U S A. 2017 02 28; 114(9):2343-2348.