"Clozapine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
| Descriptor ID |
D003024
|
| MeSH Number(s) |
D03.633.300.240.220
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Clozapine".
Below are MeSH descriptors whose meaning is more specific than "Clozapine".
This graph shows the total number of publications written about "Clozapine" by people in this website by year, and whether "Clozapine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 2 | 1 | 3 |
| 2017 | 15 | 1 | 16 |
| 2018 | 5 | 1 | 6 |
| 2019 | 1 | 1 | 2 |
| 2020 | 3 | 0 | 3 |
| 2021 | 2 | 0 | 2 |
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Below are the most recent publications written about "Clozapine" by people in Profiles.
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COVID-19: Risks, Complications, and Monitoring in Patients on Clozapine. Pharmacopsychiatry. 2022 Jan; 55(1):48-56.
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Clozapine Is Associated With Higher COVID-19 Infection Rate in Veterans With Schizophrenia or Schizoaffective Disorder. J Clin Psychiatry. 2021 08 24; 82(5).
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Severe granulocytopenia in a patient on long-term use of clozapine and with COVID-19. Psychiatry Res. 2021 11; 305:114171.
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The potential interaction between COVID-19 vaccines and clozapine: A novel approach for clinical trials. Int J Clin Pract. 2021 Aug; 75(8):e14441.
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Clozapine treatment and risk of COVID-19 infection: retrospective cohort study. Br J Psychiatry. 2021 07; 219(1):368-374.
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Clozapine-related immunodeficiency: Implications for Parkinson's disease psychosis in the context of the COVID-19 pandemic. Rev Neurol (Paris). 2021 10; 177(8):849-851.
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The effect of prohibiting outside food during COVID-19 pandemic on the body weight of schizophrenic patients taking olanzapine or clozapine: a retrospective self-controlled study. Ann Palliat Med. 2021 May; 10(5):5010-5016.
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Clozapine prescribing and safety during COVID-19. Asian J Psychiatr. 2021 Jun; 60:102658.
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The impact of COVID-19 on a cohort of patients treated with clozapine. Ir J Psychol Med. 2021 12; 38(4):249-257.
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Clozapine treatment: Ensuring ongoing monitoring during the COVID-19 pandemic. Psychiatriki. 2021 Jul 10; 32(2):165-166.