Suppressor of Cytokine Signaling 3 Protein
"Suppressor of Cytokine Signaling 3 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS3 inhibits cytokine signaling by binding to RECEPTOR PROTEIN-TYROSINE KINASES as well as CYTOKINE RECEPTOR GP130; ERYTHROPOIETIN RECEPTORS; INSULIN RECEPTOR; and the LEPTIN RECEPTOR. Its functions include suppression of ERYTHROPOIESIS in the fetal liver.
| Descriptor ID |
D000071223
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| MeSH Number(s) |
D12.644.360.024.374.750 D12.776.157.057.249.750 D12.776.476.024.437.750
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Suppressor of Cytokine Signaling 3 Protein".
Below are MeSH descriptors whose meaning is more specific than "Suppressor of Cytokine Signaling 3 Protein".
This graph shows the total number of publications written about "Suppressor of Cytokine Signaling 3 Protein" by people in this website by year, and whether "Suppressor of Cytokine Signaling 3 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 2 | 2 |
| 2017 | 3 | 2 | 5 |
| 2018 | 2 | 3 | 5 |
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Below are the most recent publications written about "Suppressor of Cytokine Signaling 3 Protein" by people in Profiles.
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SOCS, Intrinsic Virulence Factors, and Treatment of COVID-19. Front Immunol. 2020; 11:582102.
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The aspartate aminotransferase/platelet count ratio index (APRI) in dengue. J Med Virol. 2019 05; 91(5):723.
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Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection. Nat Microbiol. 2019 02; 4(2):258-268.
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The Coronavirus Transmissible Gastroenteritis Virus Evades the Type I Interferon Response through IRE1a-Mediated Manipulation of the MicroRNA miR-30a-5p/SOCS1/3 Axis. J Virol. 2018 11 15; 92(22).
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CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling. EMBO J. 2018 09 14; 37(18).
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SOCS1 and SOCS3 Target IRF7 Degradation To Suppress TLR7-Mediated Type I IFN Production of Human Plasmacytoid Dendritic Cells. J Immunol. 2018 06 15; 200(12):4024-4035.
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SOCS3 Is Upregulated and Targeted by miR30a-5p in Allergic Rhinitis. Int Arch Allergy Immunol. 2018; 175(4):209-219.
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Altered expression of interferon-stimulated genes is strongly associated with therapeutic outcomes in hepatitis B virus infection. Antiviral Res. 2017 Nov; 147:75-85.
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Protective effects of SOCS3 overexpression in high glucose-induced lung epithelial cell injury through the JAK2/STAT3 pathway. Mol Med Rep. 2017 Sep; 16(3):2668-2674.
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NAFLD and Atherosclerosis Are Prevented by a Natural Dietary Supplement Containing Curcumin, Silymarin, Guggul, Chlorogenic Acid and Inulin in Mice Fed a High-Fat Diet. Nutrients. 2017 May 13; 9(5).