"Apelin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 77 amino acid secreted endogenous ligand for the angiotensin II receptor-like 1 protein (APELIN RECEPTOR) that is proteolytically cleaved into four smaller peptides: Apelin-36, Apelin-31, Apelin-28, and Apelin-13. It inhibits entry of HIV into cells that express both APJ and CD4 ANTIGEN and is highly expressed in breast milk, where it may modulate the neonatal immune response.
| Descriptor ID |
D000073861
|
| MeSH Number(s) |
D12.644.276.150 D23.529.134
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Apelin".
Below are MeSH descriptors whose meaning is more specific than "Apelin".
This graph shows the total number of publications written about "Apelin" by people in this website by year, and whether "Apelin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2017 | 2 | 3 | 5 |
| 2018 | 2 | 0 | 2 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Apelin" by people in Profiles.
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Abnormal apelin-ACE2 and SGLT2 signaling contribute to adverse cardiorenal injury in patients with COVID-19. Int J Cardiol. 2021 08 01; 336:123-129.
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Cannabidiol (CBD) modulation of apelin in acute respiratory distress syndrome. J Cell Mol Med. 2020 11; 24(21):12869-12872.
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Genes encoding ACE2, TMPRSS2 and related proteins mediating SARS-CoV-2 viral entry are upregulated with age in human cardiomyocytes. J Mol Cell Cardiol. 2020 10; 147:88-91.
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Apelin-potential therapy for COVID-19? J Mol Cell Cardiol. 2020 08; 145:84-87.
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The apelinergic system: a perspective on challenges and opportunities in cardiovascular and metabolic disorders. Ann N Y Acad Sci. 2019 11; 1455(1):12-33.
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Apelinergic system in the kidney: implications for diabetic kidney disease. Physiol Rep. 2018 Dec; 6(23):e13939.
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The exerkine apelin reverses age-associated sarcopenia. Nat Med. 2018 09; 24(9):1360-1371.
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CCK reduces the food intake mainly through CCK1R in Siberian sturgeon (Acipenser baerii Brandt). Sci Rep. 2017 09 29; 7(1):12413.
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Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin's glucose-lowering effects. Sci Transl Med. 2017 Sep 13; 9(407).
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Apelin administration improves insulin sensitivity in overweight men during hyperinsulinaemic-euglycaemic clamp. Diabetes Obes Metab. 2018 01; 20(1):157-164.