"Apolipoproteins E" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.
| Descriptor ID |
D001057
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| MeSH Number(s) |
D10.532.091.500 D12.776.070.400.500 D12.776.521.120.500
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Apolipoproteins E".
Below are MeSH descriptors whose meaning is more specific than "Apolipoproteins E".
This graph shows the total number of publications written about "Apolipoproteins E" by people in this website by year, and whether "Apolipoproteins E" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1996 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2005 | 2 | 0 | 2 |
| 2006 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 2 | 1 | 3 |
| 2010 | 1 | 0 | 1 |
| 2012 | 2 | 2 | 4 |
| 2013 | 0 | 1 | 1 |
| 2015 | 1 | 1 | 2 |
| 2016 | 1 | 3 | 4 |
| 2017 | 13 | 17 | 30 |
| 2018 | 12 | 7 | 19 |
| 2019 | 1 | 5 | 6 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 1 | 2 |
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Below are the most recent publications written about "Apolipoproteins E" by people in Profiles.
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Association of ApoE isoforms with COVID-19 outcomes: a world-wide epidemiological study. Hum Cell. 2021 Nov; 34(6):1932-1933.
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High plasma concentration of non-esterified polyunsaturated fatty acids is a specific feature of severe COVID-19 pneumonia. Sci Rep. 2021 05 24; 11(1):10824.
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COVID-19 enters the expanding network of apolipoprotein E4-related pathologies. Redox Biol. 2021 05; 41:101938.
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The ApoE Locus and COVID-19: Are We Going Where We Have Been? J Gerontol A Biol Sci Med Sci. 2021 01 18; 76(2):e1-e3.
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ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response. Cell Stem Cell. 2021 02 04; 28(2):331-342.e5.
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The S1 protein of SARS-CoV-2 crosses the blood-brain barrier in mice. Nat Neurosci. 2021 03; 24(3):368-378.
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Response to Comment on "ApoE e4e4 Genotype and Mortality With COVID-19 in UK Biobank" by Kuo et al. J Gerontol A Biol Sci Med Sci. 2020 10 15; 75(11):2235-2236.
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Comment on "ApoE e4e4 Genotype and Mortality With COVID-19 in UK Biobank" by Kuo et al. J Gerontol A Biol Sci Med Sci. 2020 10 15; 75(11):2233-2234.
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ApoE e4e4 Genotype and Mortality With COVID-19 in UK Biobank. J Gerontol A Biol Sci Med Sci. 2020 09 16; 75(9):1801-1803.
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Commentary: APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort. Front Immunol. 2020; 11:1939.