Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
"Leucine-Rich Repeat Serine-Threonine Protein Kinase-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine/threonine protein kinase with GTPase activity that contains 12 LEUCINE-rich repeats in its central region and 7 WD repeats C-terminal to its kinase and GTPase domains. It localizes to TRANSPORT VESICLES; the OUTER MITOCHONDRIAL MEMBRANE; and the GOLGI APPARATUS. It functions in PROTEIN TRANSPORT; regulates neuron morphology in the central nervous system, and also functions in the trafficking of SYNAPTIC VESICLES. Mutations in the LRRK2 gene have been identified in autosomal dominant cases of PARKINSON DISEASE (PARK8).
| Descriptor ID |
D000071158
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| MeSH Number(s) |
D08.811.913.696.620.682.700.534 D12.776.637.750
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Leucine-Rich Repeat Serine-Threonine Protein Kinase-2".
Below are MeSH descriptors whose meaning is more specific than "Leucine-Rich Repeat Serine-Threonine Protein Kinase-2".
This graph shows the total number of publications written about "Leucine-Rich Repeat Serine-Threonine Protein Kinase-2" by people in this website by year, and whether "Leucine-Rich Repeat Serine-Threonine Protein Kinase-2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 4 | 0 | 4 |
| 2017 | 4 | 1 | 5 |
| 2018 | 4 | 0 | 4 |
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Below are the most recent publications written about "Leucine-Rich Repeat Serine-Threonine Protein Kinase-2" by people in Profiles.
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Dopamine D2 receptor activation potently inhibits striatal glutamatergic transmission in a G2019S LRRK2 genetic model of Parkinson's disease. Neurobiol Dis. 2018 10; 118:1-8.
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Case-control analysis of LRRK2 protective variants in Essential Tremor. Sci Rep. 2018 03 28; 8(1):5346.
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Dopamine D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson's disease. Cell Death Dis. 2018 02 12; 9(2):204.
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Association of LRRK2 Haplotype With Age at Onset in Parkinson Disease. JAMA Neurol. 2018 01 01; 75(1):127-128.
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Case-control analysis of leucine-rich repeat kinase 2 protective variants in Alzheimer's disease. Neurobiol Aging. 2018 04; 64:157.e7-157.e9.
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LRRK2 interacts with ATM and regulates Mdm2-p53 cell proliferation axis in response to genotoxic stress. Hum Mol Genet. 2017 11 15; 26(22):4494-4505.
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Promising rodent models in Parkinson's disease. Parkinsonism Relat Disord. 2018 Jan; 46 Suppl 1:S10-S14.
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Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease. Sci Signal. 2017 Jul 18; 10(488).
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Targeting LRRK2 in Parkinson's disease: an update on recent developments. Expert Opin Ther Targets. 2017 Jun; 21(6):601-610.
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Reprogramming of a human induced pluripotent stem cell (iPSC) line from a Parkinson's disease patient with a R1628P variant in the LRRK2 gene. Stem Cell Res. 2017 01; 18:45-47.