Suppressor of Cytokine Signaling 1 Protein
"Suppressor of Cytokine Signaling 1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS1 functions as a negative regulator of CYTOKINES that signal through the JANUS KINASES-STAT 3 TRANSCRIPTION FACTOR (JAK/STAT3) pathway by inhibiting the activity of JANUS KINASES.
| Descriptor ID |
D000071222
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| MeSH Number(s) |
D12.644.360.024.374.500 D12.776.157.057.249.500 D12.776.476.024.437.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Suppressor of Cytokine Signaling 1 Protein".
Below are MeSH descriptors whose meaning is more specific than "Suppressor of Cytokine Signaling 1 Protein".
This graph shows the total number of publications written about "Suppressor of Cytokine Signaling 1 Protein" by people in this website by year, and whether "Suppressor of Cytokine Signaling 1 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 2 | 3 | 5 |
| 2019 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Suppressor of Cytokine Signaling 1 Protein" by people in Profiles.
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SOCS, Intrinsic Virulence Factors, and Treatment of COVID-19. Front Immunol. 2020; 11:582102.
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Immune dysregulation and multisystem inflammatory syndrome in children (MIS-C) in individuals with haploinsufficiency of SOCS1. J Allergy Clin Immunol. 2020 11; 146(5):1194-1200.e1.
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The IL-6 signaling complex is a critical driver, negative prognostic factor, and therapeutic target in diffuse large B-cell lymphoma. EMBO Mol Med. 2019 10; 11(10):e10576.
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The Coronavirus Transmissible Gastroenteritis Virus Evades the Type I Interferon Response through IRE1a-Mediated Manipulation of the MicroRNA miR-30a-5p/SOCS1/3 Axis. J Virol. 2018 11 15; 92(22).
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Dendritic cells with increased expression of suppressor of cytokine signaling 1(SOCS1) gene ameliorate lipopolysaccharide/d-galactosamine-induced acute liver failure. Mol Immunol. 2018 09; 101:10-18.
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SOCS1 and SOCS3 Target IRF7 Degradation To Suppress TLR7-Mediated Type I IFN Production of Human Plasmacytoid Dendritic Cells. J Immunol. 2018 06 15; 200(12):4024-4035.
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Evaluation of the TLR negative regulatory network in CVID patients. Genes Immun. 2019 03; 20(3):198-206.
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CpG Island Methylation Patterns in Relapsing-Remitting Multiple Sclerosis. J Mol Neurosci. 2018 Mar; 64(3):478-484.
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AXL promotes Zika virus infection in astrocytes by antagonizing type I interferon signalling. Nat Microbiol. 2018 03; 3(3):302-309.
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Mutations of CREBBP and SOCS1 are independent prognostic factors in diffuse large B cell lymphoma: mutational analysis of the SAKK 38/07 prospective clinical trial cohort. J Hematol Oncol. 2017 03 17; 10(1):70.