"Pyrin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tripartite motif protein that consists of an N-terminal pyrin domain, a central coiled-coil region and B-box type ZINC FINGER, and C-terminal regions that mediate homotrimerization and interactions with other proteins (the B30.2/SPRY DOMAIN). It is expressed primarily by mature GRANULOCYTES and associates with the cytoskeleton in the perinuclear area as well as AUTOPHAGOSOMES, where it co-ordinates the assembly of AUTOPHAGY-RELATED PROTEINS and degradation of INFLAMMASOME components. It functions in INNATE IMMUNITY and INFLAMMATION; mutations in the Pyrin protein (MEFV) gene are associated with FAMILIAL MEDITERRANEAN FEVER.
| Descriptor ID |
D000071198
|
| MeSH Number(s) |
D12.776.220.909 D12.776.934.750
|
| Concept/Terms |
Pyrin- Pyrin
- MEFV Protein
- TRIM20 Protein
- Mediterranean Fever Protein
- Marenostrin
|
Below are MeSH descriptors whose meaning is more general than "Pyrin".
Below are MeSH descriptors whose meaning is more specific than "Pyrin".
This graph shows the total number of publications written about "Pyrin" by people in this website by year, and whether "Pyrin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 1 | 0 | 1 |
| 2017 | 2 | 0 | 2 |
| 2018 | 2 | 2 | 4 |
| 2019 | 0 | 2 | 2 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Pyrin" by people in Profiles.
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Familial Mediterranean Fever and COVID-19: Friends or Foes? Front Immunol. 2020; 11:574593.
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Could MEFV mutation carriage status have a protective role for COVID-19 pandemic? Med Hypotheses. 2020 11; 144:109889.
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Neutrophilic Dermatoses Associated with Myeloid Malignancies. Am J Clin Dermatol. 2019 Jun; 20(3):325-333.
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Orthopedic and orthodontic management in a patient with DiGeorge Syndrome and Familial Mediterranean Fever: A case report. Spec Care Dentist. 2019 May; 39(3):340-347.
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Polyarteritis nodosa: lessons from 25 years of experience. Clin Exp Rheumatol. 2019 Mar-Apr; 37 Suppl 117(2):52-56.
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The pyrin inflammasome: from sensing RhoA GTPases-inhibiting toxins to triggering autoinflammatory syndromes. Pathog Dis. 2018 04 01; 76(3).
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Genetics in TNF-TNFR pathway: A complex network causing spondyloarthritis and conditioning response to anti-TNFa therapy. PLoS One. 2018; 13(3):e0194693.
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Familial Mediterranean fever mutations are hypermorphic mutations that specifically decrease the activation threshold of the Pyrin inflammasome. Rheumatology (Oxford). 2018 01 01; 57(1):100-111.
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PFAPA Syndrome in a Population with Endemic Familial Mediterranean Fever. J Pediatr. 2018 01; 192:253-255.
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Egyptian tale from India: application of whole-exome sequencing in diagnosis of atypical familial Mediterranean fever. Int J Rheum Dis. 2017 Nov; 20(11):1770-1775.