NLR Family, Pyrin Domain-Containing 3 Protein
"NLR Family, Pyrin Domain-Containing 3 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An NLR protein that contains an N-terminal PYRIN DOMAIN and ATP-binding site and 9 C-terminal LEUCINE-rich repeats; it is expressed primarily by MACROPHAGES. It is a core component of the INFLAMMASOME and directs its assembly in response to pathogen infection and damage-associated stimuli. Mutations in the NLRP3 gene are associated with FAMILIAL COLD AUTOINFLAMMATORY SYNDROME.
| Descriptor ID |
D000071199
|
| MeSH Number(s) |
D12.644.360.539.250
|
| Concept/Terms |
NLR Family, Pyrin Domain-Containing 3 Protein- NLR Family, Pyrin Domain-Containing 3 Protein
- NLR Family, Pyrin Domain Containing 3 Protein
- Cold Autoinflammatory Syndrome 1 Protein
- NACHT, LRR and PYD Domains-Containing Protein 3
- NACHT, LRR and PYD Domains Containing Protein 3
- NLRP3 Protein
|
Below are MeSH descriptors whose meaning is more general than "NLR Family, Pyrin Domain-Containing 3 Protein".
Below are MeSH descriptors whose meaning is more specific than "NLR Family, Pyrin Domain-Containing 3 Protein".
This graph shows the total number of publications written about "NLR Family, Pyrin Domain-Containing 3 Protein" by people in this website by year, and whether "NLR Family, Pyrin Domain-Containing 3 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 0 | 4 | 4 |
| 2016 | 0 | 3 | 3 |
| 2017 | 26 | 11 | 37 |
| 2018 | 28 | 14 | 42 |
| 2019 | 18 | 4 | 22 |
| 2020 | 2 | 4 | 6 |
| 2021 | 2 | 2 | 4 |
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Below are the most recent publications written about "NLR Family, Pyrin Domain-Containing 3 Protein" by people in Profiles.
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HMGB1, NLRP3, IL-6 and ACE2 levels are elevated in COVID-19 with headache: a window to the infection-related headache mechanism. J Headache Pain. 2021 Aug 12; 22(1):94.
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NLRP3 inflammasome activation and oxidative stress status in the mild and moderate SARS-CoV-2 infected patients: impact of melatonin as a medicinal supplement. Z Naturforsch C J Biosci. 2022 Jan 27; 77(1-2):37-42.
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SARS-CoV-2 nucleocapsid suppresses host pyroptosis by blocking Gasdermin D cleavage. EMBO J. 2021 09 15; 40(18):e108249.
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SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation. Nat Commun. 2021 08 02; 12(1):4664.
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NLRP3 and Infections: ß-Amyloid in Inflammasome beyond Neurodegeneration. Int J Mol Sci. 2021 Jun 29; 22(13).
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An evidence that SARS-Cov-2/COVID-19 spike protein (SP) damages hematopoietic stem/progenitor cells in the mechanism of pyroptosis in Nlrp3 inflammasome-dependent manner. Leukemia. 2021 10; 35(10):3026-3029.
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Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice. Elife. 2021 06 21; 10.
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The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies. Cytokine Growth Factor Rev. 2021 10; 61:2-15.
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Long-lived macrophage reprogramming drives spike protein-mediated inflammasome activation in COVID-19. EMBO Mol Med. 2021 08 09; 13(8):e14150.
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Migraine and neuroinflammation: the inflammasome perspective. J Headache Pain. 2021 Jun 10; 22(1):55.