"Patched-1 Receptor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A patched receptor for several HEDGEHOG PROTEINS that associates with the SMOOTHENED RECEPTOR to modulate hedgehog signaling. It is also a TUMOR SUPPRESSOR PROTEIN; mutations in the patched-1 gene are associated with BASAL CELL NEVUS SYNDROME; SQUAMOUS CELL CARCNIOMA of the ESOPHAGUS; trichoepitheliomas, and CARCINOMA, TRANSITIONAL CELL of the URINARY BLADDER.
| Descriptor ID |
D000072081
|
| MeSH Number(s) |
D12.776.543.750.058.500 D12.776.624.776.633.500
|
| Concept/Terms |
Patched-1 Receptor- Patched-1 Receptor
- Patched 1 Receptor
- Receptor, Patched-1
- PTCH1 Protein
- Patched Homolog-1
- Patched Homolog 1
- Patched-1 Protein
- Patched 1 Protein
- Patched Receptor-1
- Patched Receptor 1
- Receptor-1, Patched
|
Below are MeSH descriptors whose meaning is more general than "Patched-1 Receptor".
Below are MeSH descriptors whose meaning is more specific than "Patched-1 Receptor".
This graph shows the total number of publications written about "Patched-1 Receptor" by people in this website by year, and whether "Patched-1 Receptor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 1 | 1 |
| 2017 | 1 | 1 | 2 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Patched-1 Receptor" by people in Profiles.
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The Effect of PTCH1 on Ovarian Cancer Cell Proliferation and Apoptosis. Cancer Biother Radiopharm. 2019 Mar; 34(2):103-109.
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Alcohol Reduces Arterial Remodeling by Inhibiting Sonic Hedgehog-Stimulated Stem Cell Antigen-1 Positive Progenitor Stem Cell Expansion. Alcohol Clin Exp Res. 2017 Dec; 41(12):2051-2065.
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PTCH1 is a reliable marker for predicting imatinib response in chronic myeloid leukemia patients in chronic phase. PLoS One. 2017; 12(7):e0181366.
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Hedgehog-responsive mesenchymal clusters direct patterning and emergence of intestinal villi. Proc Natl Acad Sci U S A. 2012 Sep 25; 109(39):15817-22.