"Forkhead Box Protein O1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A forkhead box transcription factor that is a major target of INSULIN signaling and regulator of metabolic homeostasis in response to OXIDATIVE STRESS. It binds to the insulin RESPONSE ELEMENT (IRE) and the related Daf-16 family binding element (DBE). Its activity is suppressed by insulin and it also regulates OSTEOBLAST proliferation, controls bone mass, and skeletal regulation of GLUCOSE metabolism. It promotes GLUCONEOGENESIS in HEPATOCYTES and regulates gene expression in ADIPOSE TISSUE. It is also an important CELL DEATH regulator. Chromosomal aberrations involving the FOXO1 gene occur in RHABDOMYOSARCOMA.
| Descriptor ID |
D000071161
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| MeSH Number(s) |
D12.776.260.950.249.250 D12.776.930.977.249.250
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Forkhead Box Protein O1".
Below are MeSH descriptors whose meaning is more specific than "Forkhead Box Protein O1".
This graph shows the total number of publications written about "Forkhead Box Protein O1" by people in this website by year, and whether "Forkhead Box Protein O1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2017 | 1 | 5 | 6 |
| 2018 | 1 | 3 | 4 |
| 2019 | 4 | 1 | 5 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Forkhead Box Protein O1" by people in Profiles.
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Activation of mTORC1 at late endosomes misdirects T cell fate decision in older individuals. Sci Immunol. 2021 06 18; 6(60).
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Genetic variants in Forkhead box O1 associated with predisposition to sepsis in a Chinese Han population. BMC Infect Dis. 2019 Sep 06; 19(1):781.
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Expression of REG? in atherosclerotic plaques and promotes endothelial cells apoptosis via the cyclophilin A pathway indicates functional implications in atherogenesis. Cell Cycle. 2019 09; 18(17):2083-2098.
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Cyclophilin A-FoxO1 signaling pathway in endothelial cell apoptosis. Cell Signal. 2019 09; 61:57-65.
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CFTR and FOXO1 gene expression are reduced and high mobility group box 1 (HMGB1) is increased in the ovaries and serum of women with polycystic ovarian syndrome. Gynecol Endocrinol. 2019 Oct; 35(10):842-846.
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HDAC4 mutations cause diabetes and induce ß-cell FoxO1 nuclear exclusion. Mol Genet Genomic Med. 2019 05; 7(5):e602.
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Glucose-sensing microRNA-21 disrupts ROS homeostasis and impairs antioxidant responses in cellular glucose variability. Cardiovasc Diabetol. 2018 07 23; 17(1):105.
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Sirtuin 1 regulates pulmonary artery smooth muscle cell proliferation: role in pulmonary arterial hypertension. J Hypertens. 2018 05; 36(5):1164-1177.
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HGF and BFGF Secretion by Human Adipose-Derived Stem Cells Improves Ovarian Function During Natural Aging via Activation of the SIRT1/FOXO1 Signaling Pathway. Cell Physiol Biochem. 2018; 45(4):1316-1332.
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Cudratricusxanthone A attenuates sepsis-induced liver injury via SIRT1 signaling. J Cell Physiol. 2018 07; 233(7):5441-5446.