"Disulfiram" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
| Descriptor ID |
D004221
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| MeSH Number(s) |
D02.241.081.251.869.220.250 D02.886.520.150.175 D02.886.706.200.200
|
| Concept/Terms |
Disulfiram- Disulfiram
- Bis(diethylthiocarbamoyl) Disulfide
- Tetraethylthioperoxydicarbonic Diamide, ((H2N)C(S))2S2
- Tetraethylthiuram Disulfide
- Disulfide, Tetraethylthiuram
|
Below are MeSH descriptors whose meaning is more general than "Disulfiram".
Below are MeSH descriptors whose meaning is more specific than "Disulfiram".
This graph shows the total number of publications written about "Disulfiram" by people in this website by year, and whether "Disulfiram" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 1 | 0 | 1 |
| 2017 | 3 | 0 | 3 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Disulfiram" by people in Profiles.
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A computational evaluation of targeted oxidation strategy (TOS) for potential inhibition of SARS-CoV-2 by disulfiram and analogues. Biophys Chem. 2021 09; 276:106610.
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COVID-19 and related symptoms in patients under disulfiram for alcohol use disorder. Intern Emerg Med. 2021 09; 16(6):1729-1731.
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Disulfiram Ethanol Reaction with Alcohol-Based Hand Sanitizer: An Exploratory Study. Alcohol Alcohol. 2021 Jan 04; 56(1):42-46.
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Is Alcohol in Hand Sanitizers Absorbed Through the Skin or Lungs? Implications for Disulfiram Treatment. Alcohol Alcohol. 2020 Jun 25; 55(4):354-356.
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Effect of lockdown following COVID-19 pandemic on alcohol use and help-seeking behavior: Observations and insights from a sample of alcohol use disorder patients under treatment from a tertiary care center. Psychiatry Clin Neurosci. 2020 08; 74(8):440-441.
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Clinical Interventions in HIV Cure Research. Adv Exp Med Biol. 2018; 1075:285-318.
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Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes. Antiviral Res. 2018 02; 150:155-163.
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Naltrexone and Disulfiram Treatment Response in Veterans With Alcohol Dependence and Co-Occurring Problem-Gambling Features. J Clin Psychiatry. 2017 Nov/Dec; 78(9):e1299-e1306.
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Disulfiram induced psychosis: Revisiting an age-old entity. Asian J Psychiatr. 2017 Dec; 30:94-95.
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Functional neural changes following behavioral therapies and disulfiram for cocaine dependence. Psychol Addict Behav. 2017 08; 31(5):534-547.