5-Aminolevulinate Synthetase
"5-Aminolevulinate Synthetase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37.
| Descriptor ID |
D000624
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| MeSH Number(s) |
D08.811.913.050.276
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| Concept/Terms |
5-Aminolevulinate Synthetase- 5-Aminolevulinate Synthetase
- 5 Aminolevulinate Synthetase
- Synthetase, 5-Aminolevulinate
- delta-Aminolevulinate Synthase
- Synthase, delta-Aminolevulinate
- delta Aminolevulinate Synthase
- 5-Aminolevulinate Synthase
- 5 Aminolevulinate Synthase
- Synthase, 5-Aminolevulinate
- Aminolevulinic Acid Synthetase
- Acid Synthetase, Aminolevulinic
- Synthetase, Aminolevulinic Acid
- delta-Aminolevulinic Acid Synthetase
- Acid Synthetase, delta-Aminolevulinic
- Synthetase, delta-Aminolevulinic Acid
- delta Aminolevulinic Acid Synthetase
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Below are MeSH descriptors whose meaning is more general than "5-Aminolevulinate Synthetase".
Below are MeSH descriptors whose meaning is more specific than "5-Aminolevulinate Synthetase".
This graph shows the total number of publications written about "5-Aminolevulinate Synthetase" by people in this website by year, and whether "5-Aminolevulinate Synthetase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2018 | 2 | 0 | 2 |
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Below are the most recent publications written about "5-Aminolevulinate Synthetase" by people in Profiles.
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Anti-Correlation between the Dynamics of the Active Site Loop and C-Terminal Tail in Relation to the Homodimer Asymmetry of the Mouse Erythroid 5-Aminolevulinate Synthase. Int J Mol Sci. 2018 06 28; 19(7).
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Recurrent attacks of acute hepatic porphyria: major role of the chronic inflammatory response in the liver. J Intern Med. 2018 07; 284(1):78-91.
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Enzymatic activities of the first two steps of liver HEME biosynthesis in experimental MHV-3 viral hepatitis. Enzyme. 1972; 13(4):224-32.