Leukoencephalopathy, Progressive Multifocal
"Leukoencephalopathy, Progressive Multifocal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)
Descriptor ID |
D007968
|
MeSH Number(s) |
C02.182.525.500 C02.256.721.500 C02.290.575 C02.839.550 C10.228.140.430.520.750.500 C10.228.140.695.750 C10.228.228.245.340.500 C10.228.228.399.750.500 C10.314.450
|
Concept/Terms |
Leukoencephalopathy, Progressive Multifocal- Leukoencephalopathy, Progressive Multifocal
- Leukoencephalopathies, Progressive Multifocal
- Multifocal Leukoencephalopathies, Progressive
- Multifocal Leukoencephalopathy, Progressive
- Progressive Multifocal Leukoencephalopathies
- Progressive Multifocal Leukoencephalopathy
- JC Polyomavirus Encephalopathy
- Encephalopathies, JC Polyomavirus
- Encephalopathy, JC Polyomavirus
- Encephalitis, JC Polyomavirus
- JC Polyomavirus Encephalitis
|
Below are MeSH descriptors whose meaning is more general than "Leukoencephalopathy, Progressive Multifocal".
- Diseases [C]
- Virus Diseases [C02]
- Central Nervous System Viral Diseases [C02.182]
- Encephalitis, Viral [C02.182.525]
- Leukoencephalopathy, Progressive Multifocal [C02.182.525.500]
- DNA Virus Infections [C02.256]
- Polyomavirus Infections [C02.256.721]
- Leukoencephalopathy, Progressive Multifocal [C02.256.721.500]
- Encephalitis, Viral [C02.290]
- Leukoencephalopathy, Progressive Multifocal [C02.290.575]
- Slow Virus Diseases [C02.839]
- Leukoencephalopathy, Progressive Multifocal [C02.839.550]
- Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
- Brain Diseases [C10.228.140]
- Encephalitis [C10.228.140.430]
- Infectious Encephalitis [C10.228.140.430.520]
- Encephalitis, Viral [C10.228.140.430.520.750]
- Leukoencephalopathy, Progressive Multifocal [C10.228.140.430.520.750.500]
- Leukoencephalopathies [C10.228.140.695]
- Leukoencephalopathy, Progressive Multifocal [C10.228.140.695.750]
- Central Nervous System Infections [C10.228.228]
- Central Nervous System Viral Diseases [C10.228.228.245]
- Encephalitis, Viral [C10.228.228.245.340]
- Leukoencephalopathy, Progressive Multifocal [C10.228.228.245.340.500]
- Infectious Encephalitis [C10.228.228.399]
- Encephalitis, Viral [C10.228.228.399.750]
- Leukoencephalopathy, Progressive Multifocal [C10.228.228.399.750.500]
- Demyelinating Diseases [C10.314]
- Leukoencephalopathy, Progressive Multifocal [C10.314.450]
Below are MeSH descriptors whose meaning is more specific than "Leukoencephalopathy, Progressive Multifocal".
This graph shows the total number of publications written about "Leukoencephalopathy, Progressive Multifocal" by people in this website by year, and whether "Leukoencephalopathy, Progressive Multifocal" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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2006 | 1 | 0 | 1 |
2007 | 0 | 1 | 1 |
2012 | 1 | 0 | 1 |
2015 | 1 | 0 | 1 |
2017 | 12 | 2 | 14 |
2018 | 10 | 2 | 12 |
2019 | 10 | 0 | 10 |
To return to the timeline, click here.
Below are the most recent publications written about "Leukoencephalopathy, Progressive Multifocal" by people in Profiles.
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Unexpected worsening of progressive multifocal leucoencephalopathy following COVID-19 pneumonia. J Neurovirol. 2021 06; 27(3):510-513.
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Biological Significance of Anti-SARS-CoV-2 Antibodies: Lessons Learned From Progressive Multifocal Leukoencephalopathy. Neurol Neuroimmunol Neuroinflamm. 2021 03; 8(2).
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Effectiveness of Immune Checkpoint Inhibitors in Transplant Recipients with Progressive Multifocal Leukoencephalopathy. Emerg Infect Dis. 2019 11; 25(11):2145-2147.
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Progressive multifocal leukoencephalopathy: A 25-year retrospective cohort study. Neurol Neuroimmunol Neuroinflamm. 2019 11; 6(6).
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Extensive immune reconstitution inflammatory syndrome in Fingolimod-associated PML: a case report with 7 Tesla MRI data. BMC Neurol. 2019 Aug 09; 19(1):190.
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Should frequent MRI monitoring be performed in natalizumab-treated MS patients? A contribution to a recent debate. Mult Scler. 2020 09; 26(10):1227-1236.
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A 41-year-old female with progressive multifocal leukoencephalopathy after liver transplant. J Neurovirol. 2019 08; 25(4):605-607.
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Treatment of Progressive Multifocal Leukoencephalopathy with Nivolumab. N Engl J Med. 2019 04 25; 380(17):1674-1676.
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Pembrolizumab Treatment for Progressive Multifocal Leukoencephalopathy. N Engl J Med. 2019 04 25; 380(17):1597-1605.
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Treatment of Progressive Multifocal Leukoencephalopathy with Pembrolizumab. N Engl J Med. 2019 04 25; 380(17):1676-1677.