"Clathrin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. Each molecule of clathrin consists of three light chains (CLATHRIN LIGHT CHAINS) and three heavy chains (CLATHRIN HEAVY CHAINS) that form a structure called a triskelion. Clathrin also interacts with cytoskeletal proteins.
| Descriptor ID |
D002966
|
| MeSH Number(s) |
D12.776.543.990.200
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Clathrin".
Below are MeSH descriptors whose meaning is more specific than "Clathrin".
This graph shows the total number of publications written about "Clathrin" by people in this website by year, and whether "Clathrin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2017 | 0 | 4 | 4 |
| 2018 | 4 | 7 | 11 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Clathrin" by people in Profiles.
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Strategies to target SARS-CoV-2 entry and infection using dual mechanisms of inhibition by acidification inhibitors. PLoS Pathog. 2021 07; 17(7):e1009706.
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NPC1-regulated dynamic of clathrin-coated pits is essential for viral entry. Sci China Life Sci. 2022 02; 65(2):341-361.
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Dynamic Dissection of the Endocytosis of Porcine Epidemic Diarrhea Coronavirus Cooperatively Mediated by Clathrin and Caveolae as Visualized by Single-Virus Tracking. mBio. 2021 03 30; 12(2).
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Psychiatry and COVID-19: The Role of Chlorpromazine. Can J Psychiatry. 2020 10; 65(10):739-740.
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PEDV enters cells through clathrin-, caveolae-, and lipid raft-mediated endocytosis and traffics via the endo-/lysosome pathway. Vet Res. 2020 Feb 10; 51(1):10.
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Dynamics of transmissible gastroenteritis virus internalization unraveled by single-virus tracking in live cells. FASEB J. 2020 03; 34(3):4653-4669.
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Mortalin restricts porcine epidemic diarrhea virus entry by downregulating clathrin-mediated endocytosis. Vet Microbiol. 2019 Dec; 239:108455.
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Mechanical cues modulate cellular uptake of nanoparticles in cancer via clathrin-mediated and caveolae-mediated endocytosis pathways. Nanomedicine (Lond). 2019 03; 14(5):613-626.
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Infectious bronchitis virus entry mainly depends on clathrin mediated endocytosis and requires classical endosomal/lysosomal system. Virology. 2019 02; 528:118-136.
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Exosomes Exploit the Virus Entry Machinery and Pathway To Transmit Alpha Interferon-Induced Antiviral Activity. J Virol. 2018 12 15; 92(24).