Dimethylallyltranstransferase
"Dimethylallyltranstransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that, in the pathway of cholesterol biosynthesis, catalyzes the condensation of isopentenyl pyrophosphate and dimethylallylpyrophosphate to yield pyrophosphate and geranylpyrophosphate. The enzyme then catalyzes the condensation of the latter compound with another molecule of isopentenyl pyrophosphate to yield pyrophosphate and farnesylpyrophosphate. EC 2.5.1.1.
| Descriptor ID |
D004122
|
| MeSH Number(s) |
D08.811.913.225.400
|
| Concept/Terms |
Dimethylallyltranstransferase- Dimethylallyltranstransferase
- Dolichyl Phosphate Synthetase
- Nerylpyrophosphate Synthetase
- Synthetase, Nerylpyrophosphate
- Prenyltransferase
- Dimethylallyltransferase
- Geranylpyrophosphate Synthetase
- Synthetase, Geranylpyrophosphate
|
Below are MeSH descriptors whose meaning is more general than "Dimethylallyltranstransferase".
Below are MeSH descriptors whose meaning is more specific than "Dimethylallyltranstransferase".
This graph shows the total number of publications written about "Dimethylallyltranstransferase" by people in this website by year, and whether "Dimethylallyltranstransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 1 | 2 |
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Below are the most recent publications written about "Dimethylallyltranstransferase" by people in Profiles.
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Reduced Activity of Geranylgeranyl Diphosphate Synthase Mutant Is Involved in Bisphosphonate-Induced Atypical Fractures. Mol Pharmacol. 2018 12; 94(6):1391-1400.
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Functional Characterization of a GGPPS Variant Identified in Atypical Femoral Fracture Patients and Delineation of the Role of GGPPS in Bone-Relevant Cell Types. J Bone Miner Res. 2018 12; 33(12):2091-2098.
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GGPS1 Mutation and Atypical Femoral Fractures with Bisphosphonates. N Engl J Med. 2017 05 04; 376(18):1794-1795.