"Fluorouracil" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
Descriptor ID |
D005472
|
MeSH Number(s) |
D03.383.742.698.875.404
|
Concept/Terms |
Fluorouracil- Fluorouracil
- 5FU
- 5-FU
- 5-Fluorouracil
- 5 Fluorouracil
- Fluoruracil
Efudix- Efudix
- Fluoro-Uracile ICN
- Fluoro Uracile ICN
- Efudex
|
Below are MeSH descriptors whose meaning is more general than "Fluorouracil".
Below are MeSH descriptors whose meaning is more specific than "Fluorouracil".
This graph shows the total number of publications written about "Fluorouracil" by people in this website by year, and whether "Fluorouracil" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 0 | 1 | 1 |
1998 | 0 | 1 | 1 |
2003 | 0 | 2 | 2 |
2004 | 1 | 0 | 1 |
2005 | 1 | 0 | 1 |
2006 | 0 | 1 | 1 |
2007 | 0 | 1 | 1 |
2008 | 2 | 0 | 2 |
2009 | 0 | 1 | 1 |
2012 | 3 | 1 | 4 |
2013 | 0 | 1 | 1 |
2014 | 0 | 1 | 1 |
2015 | 0 | 3 | 3 |
2016 | 1 | 3 | 4 |
2017 | 11 | 22 | 33 |
2018 | 7 | 24 | 31 |
2019 | 3 | 8 | 11 |
2020 | 1 | 1 | 2 |
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Below are the most recent publications written about "Fluorouracil" by people in Profiles.
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Do clinical trials change practice? A longitudinal, international assessment of colorectal cancer prescribing practices. Cancer Treat Res Commun. 2021; 28:100445.
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NICEdrug.ch, a workflow for rational drug design and systems-level analysis of drug metabolism. Elife. 2021 08 03; 10.
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Management of colorectal cancer in the era of COVID-19: Challenges and suggestions. Sci Prog. 2021 Apr-Jun; 104(2):368504211010626.
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Population pharmacokinetic and pharmacodynamic modeling of capecitabine and its metabolites in breast cancer patients. Cancer Chemother Pharmacol. 2021 02; 87(2):229-239.
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The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2. J Virol. 2020 11 09; 94(23).
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Challenges of pancreatic cancer chemotherapy in the COVID-19 era. J Gastrointestin Liver Dis. 2020 06 04; 29(2):273-275.
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Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur. Nat Struct Mol Biol. 2020 06; 27(6):529-532.
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5-Fluorouracil in combination with deoxyribonucleosides and deoxyribose as possible therapeutic options for the Coronavirus, COVID-19 infection. Med Hypotheses. 2020 Sep; 142:109754.
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Poly(3-hydroxybutyrate-CO-3-hydroxyvalerate) PHBHV biocompatible nanocarriers for 5-FU delivery targeting colorectal cancer. Drug Deliv. 2019 Dec; 26(1):318-327.
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Radiotherapy or Chemoradiation in Unresectable Biliary Cancer: A Retrospective Study. Anticancer Res. 2019 Jun; 39(6):3095-3100.