"Deoxyribonuclease I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA.
Descriptor ID |
D003850
|
MeSH Number(s) |
D08.811.277.352.335.350.250
|
Concept/Terms |
Deoxyribonuclease I- Deoxyribonuclease I
- DNAase I
- Pancreatic DNase
- DNase, Pancreatic
- Thymonuclease
- DNA Endonuclease
- Endonuclease, DNA
- DNase I
Nickase- Nickase
- DNA Nicking Enzyme
- Endonuclease I
|
Below are MeSH descriptors whose meaning is more general than "Deoxyribonuclease I".
Below are MeSH descriptors whose meaning is more specific than "Deoxyribonuclease I".
This graph shows the total number of publications written about "Deoxyribonuclease I" by people in this website by year, and whether "Deoxyribonuclease I" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
---|
2001 | 0 | 1 | 1 |
2016 | 0 | 1 | 1 |
2017 | 2 | 1 | 3 |
2018 | 0 | 1 | 1 |
2019 | 0 | 1 | 1 |
2020 | 2 | 0 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Deoxyribonuclease I" by people in Profiles.
-
Proteome Profiling of Recombinant DNase Therapy in Reducing NETs and Aiding Recovery in COVID-19 Patients. Mol Cell Proteomics. 2021; 20:100113.
-
Long-acting nanoparticulate DNase-1 for effective suppression of SARS-CoV-2-mediated neutrophil activities and cytokine storm. Biomaterials. 2021 01; 267:120389.
-
Nebulized in-line endotracheal dornase alfa and albuterol administered to mechanically ventilated COVID-19 patients: a case series. Mol Med. 2020 09 29; 26(1):91.
-
Neutrophils and Neutrophil Extracellular Traps Regulate Immune Responses in Health and Disease. Cells. 2020 09 20; 9(9).
-
SARS-CoV2 may evade innate immune response, causing uncontrolled neutrophil extracellular traps formation and multi-organ failure. Clin Sci (Lond). 2020 06 26; 134(12):1295-1300.
-
Efficacy and safety of aerosolized intra-tracheal dornase alfa administration in patients with SARS-CoV-2-induced acute respiratory distress syndrome (ARDS): a structured summary of a study protocol for a randomised controlled trial. Trials. 2020 Jun 19; 21(1):548.
-
Harnessing innate immunity to eliminate SARS-CoV-2 and ameliorate COVID-19 disease. Physiol Genomics. 2020 05 01; 52(5):217-221.
-
Bacterial Artificial Chromosome-Based Lambda Red Recombination with the I-SceI Homing Endonuclease for Genetic Alteration of MERS-CoV. Methods Mol Biol. 2020; 2099:53-68.
-
Is there a place for dornase alfa therapy in lung transplantation? Transpl Int. 2019 06; 32(6):598-599.
-
Maladaptive role of neutrophil extracellular traps in pathogen-induced lung injury. JCI Insight. 2018 02 08; 3(3).