Peptide Chain Initiation, Translational
"Peptide Chain Initiation, Translational" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A process of GENETIC TRANSLATION whereby the formation of a peptide chain is started. It includes assembly of the RIBOSOME components, the MESSENGER RNA coding for the polypeptide to be made, INITIATOR TRNA, and PEPTIDE INITIATION FACTORS; and placement of the first amino acid in the peptide chain. The details and components of this process are unique for prokaryotic protein biosynthesis and eukaryotic protein biosynthesis.
| Descriptor ID |
D010442
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| MeSH Number(s) |
G02.111.660.871.650 G03.734.871.650
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| Concept/Terms |
Peptide Chain Initiation, Translational- Peptide Chain Initiation, Translational
- Chain Initiation, Peptide, Translational
- Protein Chain Initiation, Translational
- Protein Translation Initiation
- Translation Initiation, Protein
- Initiation, Protein Translation
- Protein Biosynthesis Initiation
- Biosynthesis Initiation, Protein
- Initiation, Protein Biosynthesis
- Translation Initiation, Genetic
- Genetic Translation Initiation
- Initiation, Genetic Translation
- Translational Peptide Chain Initiation
- Translational Initiation, Protein
- Initiation, Protein Translational
- Protein Translational Initiation
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Below are MeSH descriptors whose meaning is more general than "Peptide Chain Initiation, Translational".
Below are MeSH descriptors whose meaning is more specific than "Peptide Chain Initiation, Translational".
This graph shows the total number of publications written about "Peptide Chain Initiation, Translational" by people in this website by year, and whether "Peptide Chain Initiation, Translational" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Peptide Chain Initiation, Translational" by people in Profiles.
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Dynamic competition between SARS-CoV-2 NSP1 and mRNA on the human ribosome inhibits translation initiation. Proc Natl Acad Sci U S A. 2021 02 09; 118(6).
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SARS-CoV-2 has the advantage of competing the iMet-tRNAs with human hosts to allow efficient translation. Mol Genet Genomics. 2021 Jan; 296(1):113-118.
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Conformational switch in the ribosomal protein S1 guides unfolding of structured RNAs for translation initiation. Nucleic Acids Res. 2018 11 16; 46(20):10917-10929.
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The NS1 Protein from Influenza Virus Stimulates Translation Initiation by Enhancing Ribosome Recruitment to mRNAs. J Mol Biol. 2017 10 27; 429(21):3334-3352.
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Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3. EMBO J. 2001 Apr 17; 20(8):1829-39.
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Human coronavirus OC43 RNA 4 lacks two open reading frames located downstream of the S gene of bovine coronavirus. Virology. 1993 Jan; 192(1):355-60.