"Isoquinolines" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. The ring structure is characteristic of the group of opium alkaloids such as papaverine. (From Stedman, 25th ed)
| Descriptor ID |
D007546
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| MeSH Number(s) |
D03.633.100.531
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Isoquinolines".
Below are MeSH descriptors whose meaning is more specific than "Isoquinolines".
This graph shows the total number of publications written about "Isoquinolines" by people in this website by year, and whether "Isoquinolines" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2017 | 7 | 3 | 10 |
| 2018 | 7 | 3 | 10 |
| 2019 | 3 | 3 | 6 |
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Below are the most recent publications written about "Isoquinolines" by people in Profiles.
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CuCl2-catalyzed inexpensive, faster and ligand/additive free synthesis of isoquinolin-1(2H)-one derivatives via the coupling-cyclization strategy: Evaluation of a new class of compounds as potential PDE4 inhibitors. Bioorg Chem. 2021 10; 115:105265.
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Inhibitory effect on SARS-CoV-2 infection of neferine by blocking Ca2+ -dependent membrane fusion. J Med Virol. 2021 10; 93(10):5825-5832.
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Stenoparib, an Inhibitor of Cellular Poly(ADP-Ribose) Polymerase, Blocks Replication of the SARS-CoV-2 and HCoV-NL63 Human Coronaviruses In Vitro. mBio. 2021 01 19; 12(1).
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Ensifentrine (RPL554): an investigational PDE3/4 inhibitor for the treatment of COPD. Expert Opin Investig Drugs. 2019 Oct; 28(10):827-833.
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Antiviral therapy for HCV in hemophilia A patients with HIV-1 co-infection. Medicine (Baltimore). 2019 Jul; 98(30):e16524.
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Noninvasive quantification of macrophagic lung recruitment during experimental ventilation-induced lung injury. J Appl Physiol (1985). 2019 08 01; 127(2):546-558.
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Synthesis, thymidine phosphorylase, angiogenic inhibition and molecular docking study of isoquinoline derivatives. Bioorg Chem. 2019 08; 89:102999.
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Sustained virologic response to direct-acting antiviral therapy in patients with chronic hepatitis C and hepatocellular carcinoma: A systematic review and meta-analysis. J Hepatol. 2019 09; 71(3):473-485.
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Ensifentrine (RPL554): an inhaled 'bifunctional' dual PDE3/4 inhibitor for the treatment of asthma and chronic obstructive pulmonary disease. Pharm Pat Anal. 2018 Nov; 7(6):249-257.
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Evaluation of a non-prime site substituent and warheads combined with a decahydroisoquinolin scaffold as a SARS 3CL protease inhibitor. Bioorg Med Chem. 2019 01 15; 27(2):425-435.