Gain of Function Mutation
"Gain of Function Mutation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mutation that results in an increase in a gene's activity or in acquiring a new molecular function or a new pattern of gene expression.
Descriptor ID |
D000073659
|
MeSH Number(s) |
G05.365.590.288
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Concept/Terms |
Gain of Function Mutation- Gain of Function Mutation
- Activation Mutation
- Activation Mutations
- Mutation, Activation
- Mutations, Activation
|
Below are MeSH descriptors whose meaning is more general than "Gain of Function Mutation".
Below are MeSH descriptors whose meaning is more specific than "Gain of Function Mutation".
This graph shows the total number of publications written about "Gain of Function Mutation" by people in this website by year, and whether "Gain of Function Mutation" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2017 | 4 | 3 | 7 |
2018 | 5 | 6 | 11 |
2019 | 1 | 3 | 4 |
2020 | 1 | 1 | 2 |
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Below are the most recent publications written about "Gain of Function Mutation" by people in Profiles.
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Might SARS-CoV-2 Have Arisen via Serial Passage through an Animal Host or Cell Culture?: A potential explanation for much of the novel coronavirus' distinctive genome. Bioessays. 2020 10; 42(10):e2000091.
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[Tracing the origins of SARS-COV-2 in coronavirus phylogenies]. Med Sci (Paris). 2020 Aug-Sep; 36(8-9):783-796.
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Rethinking Gain-of-Function Experiments in the Context of the COVID-19 Pandemic. mBio. 2020 08 07; 11(4).
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Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Kinase Transcriptional and Biochemical Function. Immunity. 2020 09 15; 53(3):672-684.e11.
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Iron Matryoshka-Haemochromatosis nested in Ferroportin Disease? Liver Int. 2019 06; 39(6):1014-1015.
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Preparing for the Next Influenza Pandemic: The Development of a Universal Influenza Vaccine. J Infect Dis. 2019 04 08; 219(Suppl_1):S107-S109.
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Interferon signature in patients with STAT1 gain-of-function mutation is epigenetically determined. Eur J Immunol. 2019 05; 49(5):790-800.
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Activating mutations in PIK3CD disrupt the differentiation and function of human and murine CD4+ T cells. J Allergy Clin Immunol. 2019 07; 144(1):236-253.
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STAT1 gain-of-function compromises skin host defense in the context of IFN-? signaling. J Allergy Clin Immunol. 2019 04; 143(4):1626-1629.e5.
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Efficacy of Ruxolitinib Therapy in a Patient With Severe Enterocolitis Associated With a STAT3 Gain-of-Function Mutation. Gastroenterology. 2019 03; 156(4):1206-1210.e1.