Immunoglobulin Fc Fragments
"Immunoglobulin Fc Fragments" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
| Descriptor ID |
D007141
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| MeSH Number(s) |
D12.644.541.500.697 D12.776.124.486.485.538.500 D12.776.124.486.485.680.697 D12.776.124.790.651.538.500 D12.776.124.790.651.680.660 D12.776.377.715.548.538.500 D12.776.377.715.548.680.660
|
| Concept/Terms |
Immunoglobulin Fc Fragments- Immunoglobulin Fc Fragments
- Fc Fragments, Immunoglobulin
- Immunoglobulins, Fc Fragment
- Fc Fragment Immunoglobulins
- Fragment Immunoglobulins, Fc
- Immunoglobulin Fc Fragment
- Fc Fragment, Immunoglobulin
- Immunoglobulins, Fc
- Fc Fragments
- Fc Immunoglobulins
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Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Fc Fragments".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Fc Fragments".
This graph shows the total number of publications written about "Immunoglobulin Fc Fragments" by people in this website by year, and whether "Immunoglobulin Fc Fragments" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2014 | 0 | 2 | 2 |
| 2015 | 1 | 1 | 2 |
| 2016 | 1 | 0 | 1 |
| 2017 | 10 | 1 | 11 |
| 2018 | 11 | 8 | 19 |
| 2019 | 7 | 4 | 11 |
| 2020 | 4 | 6 | 10 |
| 2021 | 4 | 9 | 13 |
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Below are the most recent publications written about "Immunoglobulin Fc Fragments" by people in Profiles.
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Current status of therapeutic monoclonal antibodies against SARS-CoV-2. PLoS Pathog. 2021 09; 17(9):e1009885.
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Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy. Immunity. 2021 09 14; 54(9):2143-2158.e15.
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Broad betacoronavirus neutralization by a stem helix-specific human antibody. Science. 2021 09 03; 373(6559):1109-1116.
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The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody. PLoS One. 2021; 16(6):e0253487.
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A single dose of the SARS-CoV-2 vaccine BNT162b2 elicits Fc-mediated antibody effector functions and T cell responses. Cell Host Microbe. 2021 07 14; 29(7):1137-1150.e6.
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Requirement of Fc-Fc Gamma Receptor Interaction for Antibody-Based Protection against Emerging Virus Infections. Viruses. 2021 05 31; 13(6).
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Robust and low-cost ELISA based on IgG-Fc tagged recombinant proteins to screen for anti-SARS-CoV-2 antibodies. J Immunol Methods. 2021 08; 495:113082.
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Cross-reactive coronavirus antibodies with diverse epitope specificities and Fc effector functions. Cell Rep Med. 2021 06 15; 2(6):100313.
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ACE2-based decoy receptors for SARS coronavirus 2. Proteins. 2021 09; 89(9):1065-1078.
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SARS-CoV-2 infection in patients with ß-thalassemia: Experience from Lebanon. Am J Hematol. 2021 08 01; 96(8):E285-E288.