"Rats, Zucker" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Two populations of Zucker rats have been cited in research--the "fatty" or obese and the lean. The "fatty" rat (Rattus norvegicus) appeared as a spontaneous mutant. The obese condition appears to be due to a single recessive gene.
| Descriptor ID |
D011924
|
| MeSH Number(s) |
B01.050.150.900.649.313.992.635.505.700.550.700
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Rats, Zucker".
Below are MeSH descriptors whose meaning is more specific than "Rats, Zucker".
This graph shows the total number of publications written about "Rats, Zucker" by people in this website by year, and whether "Rats, Zucker" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2017 | 0 | 5 | 5 |
| 2018 | 0 | 2 | 2 |
| 2019 | 0 | 5 | 5 |
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Below are the most recent publications written about "Rats, Zucker" by people in Profiles.
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Empagliflozin reduces the levels of CD36 and cardiotoxic lipids while improving autophagy in the hearts of Zucker diabetic fatty rats. Biochem Pharmacol. 2019 12; 170:113677.
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Alteration of thyroid hormone signaling triggers the diabetes-induced pathological growth, remodeling, and dedifferentiation of podocytes. JCI Insight. 2019 09 19; 4(18).
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Fatty Acid Desaturase Involvement in Non-Alcoholic Fatty Liver Disease Rat Models: Oxidative Stress Versus Metalloproteinases. Nutrients. 2019 Apr 08; 11(4).
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Soluble Receptor for Advanced Glycation End Products: A Protective Molecule against Intramyocardial Lipid Accumulation in Obese Zucker Rats? Mediators Inflamm. 2019; 2019:2712376.
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Animal Models of Steatosis (NAFLD) and Steatohepatitis (NASH) Exhibit Hepatic Lobe-Specific Gelatinases Activity and Oxidative Stress. Can J Gastroenterol Hepatol. 2019; 2019:5413461.
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Empagliflozin directly improves diastolic function in human heart failure. Eur J Heart Fail. 2018 12; 20(12):1690-1700.
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Melatonin increases brown adipose tissue mass and function in Zücker diabetic fatty rats: implications for obesity control. J Pineal Res. 2018 May; 64(4):e12472.
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Metformin treatment decreases nitroxidative stress, restores nitric oxide bioavailability and endothelial function beyond glucose control. Biomed Pharmacother. 2018 Feb; 98:149-156.
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Whitening and Impaired Glucose Utilization of Brown Adipose Tissue in a Rat Model of Type 2 Diabetes Mellitus. Sci Rep. 2017 12 01; 7(1):16795.
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Indazole-based ligands for estrogen-related receptor a as potential anti-diabetic agents. Eur J Med Chem. 2017 Sep 29; 138:830-853.