25-Hydroxyvitamin D3 1-alpha-Hydroxylase
"25-Hydroxyvitamin D3 1-alpha-Hydroxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).
| Descriptor ID |
D015090
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| MeSH Number(s) |
D08.244.453.499.500 D08.244.453.915.400 D08.811.682.690.708.170.493.500 D08.811.682.690.708.170.915.400 D12.776.422.220.453.499.500 D12.776.422.220.453.915.400
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| Concept/Terms |
25-Hydroxyvitamin D3 1-alpha-Hydroxylase- 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
- 25 Hydroxyvitamin D3 1 alpha Hydroxylase
- 25-Hydroxycholecalciferol 1-Hydroxylase
- Calcidiol 1-Monooxygenase
- Calcidiol 1 Monooxygenase
- 25-Hydroxyvitamin D(3) 1 alpha-Hydroxylase
- 25-Hydroxyvitamin D 1-alpha-Hydroxylase
- 1-alpha-Hydroxylase, 25-Hydroxyvitamin D
- 25 Hydroxyvitamin D 1 alpha Hydroxylase
- CYP27B1
- Cytochrome P-450 CYP27B1
- Cytochrome P 450 CYP27B1
- 25-Hydroxyergocalciferol 1-alpha-Hydroxylase
- 1-alpha-Hydroxylase, 25-Hydroxyergocalciferol
- 25 Hydroxyergocalciferol 1 alpha Hydroxylase
- 25-Hydroxycholecalciferol-1-Hydroxylase
- 25 Hydroxycholecalciferol 1 Hydroxylase
- 25-Hydroxyvitamin D2 1-hydroxylase
- 1-hydroxylase, 25-Hydroxyvitamin D2
- 25 Hydroxyvitamin D2 1 hydroxylase
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Below are MeSH descriptors whose meaning is more general than "25-Hydroxyvitamin D3 1-alpha-Hydroxylase".
Below are MeSH descriptors whose meaning is more specific than "25-Hydroxyvitamin D3 1-alpha-Hydroxylase".
This graph shows the total number of publications written about "25-Hydroxyvitamin D3 1-alpha-Hydroxylase" by people in this website by year, and whether "25-Hydroxyvitamin D3 1-alpha-Hydroxylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 3 | 4 |
| 2018 | 0 | 3 | 3 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "25-Hydroxyvitamin D3 1-alpha-Hydroxylase" by people in Profiles.
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Evaluation of expression of VDR-associated lncRNAs in COVID-19 patients. BMC Infect Dis. 2021 Jun 19; 21(1):588.
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Vitamin D enzymes (CYP27A1, CYP27B1, and CYP24A1) and receptor expression in non-melanoma skin cancer. Acta Biochim Biophys Sin (Shanghai). 2019 Apr 01; 51(4):444-447.
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Vitamin D pathway genetic variants are able to influence sofosbuvir and its main metabolite pharmacokinetics in HCV mono-infected patients. Infect Genet Evol. 2018 06; 60:42-47.
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Vitamin D pathway gene polymorphisms and hepatocellular carcinoma in chronic hepatitis C-affected patients treated with new drugs. Cancer Chemother Pharmacol. 2018 03; 81(3):615-620.
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Effect of pharmacogenetic markers of vitamin D pathway on deferasirox pharmacokinetics in children. Pharmacogenet Genomics. 2018 Jan; 28(1):17-22.
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Role of Vitamin D in Maintaining Renal Epithelial Barrier Function in Uremic Conditions. Int J Mol Sci. 2017 Nov 26; 18(12).
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Endogenous Calcitriol Synthesis Controls the Humoral IgE Response in Mice. J Immunol. 2017 12 15; 199(12):3952-3958.
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Does vitamin D play a role in autoimmune endocrine disorders? A proof of concept. Rev Endocr Metab Disord. 2017 09; 18(3):335-346.
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Vitamin D-related gene polymorphism predict treatment response to pegylated interferon-based therapy in Thai chronic hepatitis C patients. BMC Gastroenterol. 2017 Apr 17; 17(1):54.
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Age, serum 25-hydroxyvitamin D and vitamin D receptor (VDR) expression and function in peripheral blood mononuclear cells. Oncotarget. 2016 Jun 14; 7(24):35512-35521.