"Kupffer Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Specialized phagocytic cells of the MONONUCLEAR PHAGOCYTE SYSTEM found on the luminal surface of the hepatic sinusoids. They filter bacteria and small foreign proteins out of the blood, and dispose of worn out red blood cells.
| Descriptor ID |
D007728
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| MeSH Number(s) |
A11.329.372.588 A11.627.482.588 A11.733.397.588 A15.382.680.397.588 A15.382.812.522.588
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Kupffer Cells".
Below are MeSH descriptors whose meaning is more specific than "Kupffer Cells".
This graph shows the total number of publications written about "Kupffer Cells" by people in this website by year, and whether "Kupffer Cells" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 2 | 2 | 4 |
| 2018 | 3 | 3 | 6 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Kupffer Cells" by people in Profiles.
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High prevalence of hepatic steatosis and vascular thrombosis in COVID-19: A systematic review and meta-analysis of autopsy data. World J Gastroenterol. 2020 Dec 28; 26(48):7693-7706.
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A histopathological observation regarding the possibility of hemophagocytic lymphohistiocytosis in COVID-19 patients. J Gastrointestin Liver Dis. 2020 Sep 09; 29(3):475-476.
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Depletion of RIPK1 in hepatocytes exacerbates liver damage in fulminant viral hepatitis. Cell Death Dis. 2019 01 08; 10(1):12.
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Organ-Specific Fate, Recruitment, and Refilling Dynamics of Tissue-Resident Macrophages during Blood-Stage Malaria. Cell Rep. 2018 12 11; 25(11):3099-3109.e3.
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CX3CR1 differentiates F4/80low monocytes into pro-inflammatory F4/80high macrophages in the liver. Sci Rep. 2018 10 10; 8(1):15076.
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Curcumin reduces Ly6Chi monocyte infiltration to protect against liver fibrosis by inhibiting Kupffer cells activation to reduce chemokines secretion. Biomed Pharmacother. 2018 Oct; 106:868-878.
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Characterization of Pattern Recognition Receptor Expression and Functionality in Liver Primary Cells and Derived Cell Lines. J Innate Immun. 2018; 10(4):339-348.
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TLR2 Stimulation Strengthens Intrahepatic Myeloid-Derived Cell-Mediated T Cell Tolerance through Inducing Kupffer Cell Expansion and IL-10 Production. J Immunol. 2018 04 01; 200(7):2341-2351.
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Loss of toll-like receptor 3 aggravates hepatic inflammation but ameliorates steatosis in mice. Biochem Biophys Res Commun. 2018 03 18; 497(4):957-962.
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Integrated gut/liver microphysiological systems elucidates inflammatory inter-tissue crosstalk. Biotechnol Bioeng. 2017 11; 114(11):2648-2659.