Cysteine Proteinase Inhibitors
"Cysteine Proteinase Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Exogenous and endogenous compounds which inhibit CYSTEINE ENDOPEPTIDASES.
| Descriptor ID |
D015853
|
| MeSH Number(s) |
D27.505.519.389.745.325
|
| Concept/Terms |
Cysteine Proteinase Inhibitors- Cysteine Proteinase Inhibitors
- Inhibitors, Cysteine Proteinase
- Proteinase Inhibitors, Cysteine
- Cysteine Protease Inhibitors
- Inhibitors, Cysteine Protease
- Protease Inhibitors, Cysteine
- Cysteine Proteinase Antagonists
- Antagonists, Cysteine Proteinase
- Proteinase Antagonists, Cysteine
alpha-Cysteine Protease Inhibitors- alpha-Cysteine Protease Inhibitors
- Inhibitors, alpha-Cysteine Protease
- Protease Inhibitors, alpha-Cysteine
- alpha Cysteine Protease Inhibitors
|
Below are MeSH descriptors whose meaning is more general than "Cysteine Proteinase Inhibitors".
Below are MeSH descriptors whose meaning is more specific than "Cysteine Proteinase Inhibitors".
This graph shows the total number of publications written about "Cysteine Proteinase Inhibitors" by people in this website by year, and whether "Cysteine Proteinase Inhibitors" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 2 | 0 | 2 |
| 2009 | 0 | 2 | 2 |
| 2012 | 3 | 0 | 3 |
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 3 | 0 | 3 |
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 4 | 3 | 7 |
| 2021 | 8 | 1 | 9 |
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Below are the most recent publications written about "Cysteine Proteinase Inhibitors" by people in Profiles.
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Repurposing existing drugs: identification of SARS-CoV-2 3C-like protease inhibitors. J Enzyme Inhib Med Chem. 2021 Dec; 36(1):147-153.
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Drug Repurposing for the SARS-CoV-2 Papain-Like Protease. ChemMedChem. 2022 01 05; 17(1):e202100455.
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All-Trans Retinoic Acid Exhibits Antiviral Effect against SARS-CoV-2 by Inhibiting 3CLpro Activity. Viruses. 2021 08 23; 13(8).
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Evaluating Stability and Activity of SARS-CoV-2 PLpro for High-throughput Screening of Inhibitors. Mol Biotechnol. 2022 Jan; 64(1):1-8.
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Inhibition of Cysteine Proteases by 6,6'-Dihydroxythiobinupharidine (DTBN) from Nuphar lutea. Molecules. 2021 Aug 05; 26(16).
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Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV-2 3CLpro). J Med Chem. 2022 02 24; 65(4):2880-2904.
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3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents. J Med Chem. 2022 02 24; 65(4):2926-2939.
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Self-Masked Aldehyde Inhibitors: A Novel Strategy for Inhibiting Cysteine Proteases. J Med Chem. 2021 08 12; 64(15):11267-11287.
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Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2. Science. 2021 08 20; 373(6557):931-936.
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A head-to-head comparison of the inhibitory activities of 15 peptidomimetic SARS-CoV-2 3CLpro inhibitors. Bioorg Med Chem Lett. 2021 09 15; 48:128263.