"Apoptosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
| Descriptor ID |
D017209
|
| MeSH Number(s) |
G04.146.160
|
| Concept/Terms |
Apoptosis- Apoptosis
- Programmed Cell Death, Type I
|
Below are MeSH descriptors whose meaning is more general than "Apoptosis".
Below are MeSH descriptors whose meaning is more specific than "Apoptosis".
This graph shows the total number of publications written about "Apoptosis" by people in this website by year, and whether "Apoptosis" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 3 | 0 | 3 |
| 1998 | 1 | 1 | 2 |
| 1999 | 0 | 1 | 1 |
| 2000 | 1 | 0 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 1 | 2 | 3 |
| 2003 | 5 | 3 | 8 |
| 2004 | 6 | 3 | 9 |
| 2005 | 11 | 3 | 14 |
| 2006 | 1 | 8 | 9 |
| 2007 | 6 | 4 | 10 |
| 2008 | 7 | 3 | 10 |
| 2009 | 6 | 2 | 8 |
| 2010 | 7 | 5 | 12 |
| 2011 | 6 | 8 | 14 |
| 2012 | 3 | 7 | 10 |
| 2013 | 5 | 13 | 18 |
| 2014 | 7 | 11 | 18 |
| 2015 | 8 | 9 | 17 |
| 2016 | 6 | 15 | 21 |
| 2017 | 119 | 310 | 429 |
| 2018 | 113 | 278 | 391 |
| 2019 | 34 | 92 | 126 |
| 2020 | 7 | 9 | 16 |
| 2021 | 4 | 12 | 16 |
To return to the timeline, click here.
Below are the most recent publications written about "Apoptosis" by people in Profiles.
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Distinct Mitochondria-Mediated T-Cell Apoptosis Responses in Children and Adults With Coronavirus Disease 2019. J Infect Dis. 2021 10 28; 224(8):1333-1344.
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IL-6 Inhibition Reduces Neuronal Injury in a Murine Model of Ventilator-induced Lung Injury. Am J Respir Cell Mol Biol. 2021 10; 65(4):403-412.
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The Mechanisms of the Growth Inhibitory Effects of Paclitaxel on Gefitinib-resistant Non-small Cell Lung Cancer Cells. Cancer Genomics Proteomics. 2021 Sep-Oct; 18(5):661-673.
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FNDC4 and FNDC5 reduce SARS-CoV-2 entry points and spike glycoprotein S1-induced pyroptosis, apoptosis, and necroptosis in human adipocytes. Cell Mol Immunol. 2021 10; 18(10):2457-2459.
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SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS-suppressed PI3K/AKT/mTOR signaling. Biochim Biophys Acta Mol Basis Dis. 2021 12 01; 1867(12):166260.
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Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8+ T cells. Mucosal Immunol. 2021 11; 14(6):1381-1392.
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MicroRNA-28-3p inhibits angiotensin-converting enzyme 2 ectodomain shedding in 293T cells treated with the spike protein of severe acute respiratory syndrome coronavirus 2 by targeting A disintegrin and metalloproteinase 17. Int J Mol Med. 2021 Oct; 48(4).
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Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity. Sci Adv. 2021 08; 7(34).
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SARS-CoV-2 Initiates Programmed Cell Death in Platelets. Circ Res. 2021 09 03; 129(6):631-646.
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Redox-Mediated Artificial Non-Enzymatic Antioxidant MXene Nanoplatforms for Acute Kidney Injury Alleviation. Adv Sci (Weinh). 2021 09; 8(18):e2101498.