Kininogen, High-Molecular-Weight
"Kininogen, High-Molecular-Weight" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A plasma protein, molecular weight of 110 kD, that normally exists in plasma in a 1:1 complex with PREKALLIKREIN. HMWK is split by plasma kallikrein to produce BRADYKININ. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to KALLIKREINS. (From Stedman, 26th ed)
| Descriptor ID |
D019679
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| MeSH Number(s) |
D12.644.276.812.654.350 D12.776.124.125.635.480 D12.776.467.812.654.350 D12.776.811.420.350 D23.119.630.480 D23.469.050.375.425.350 D23.529.812.654.350
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| Concept/Terms |
Kininogen, High-Molecular-Weight- Kininogen, High-Molecular-Weight
- Kininogen, High Molecular Weight
- High Molecular Weight Kininogens
- Kininogens, High Molecular Weight
- HMWK
- High-Molecular-Weight Kininogens
- Kininogens, High-Molecular-Weight
- High-Molecular-Weight Kininogen
- Fitzgerald Factor
- High Molecular Weight Kininogen
|
Below are MeSH descriptors whose meaning is more general than "Kininogen, High-Molecular-Weight".
Below are MeSH descriptors whose meaning is more specific than "Kininogen, High-Molecular-Weight".
This graph shows the total number of publications written about "Kininogen, High-Molecular-Weight" by people in this website by year, and whether "Kininogen, High-Molecular-Weight" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Kininogen, High-Molecular-Weight" by people in Profiles.
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Understanding the Pathophysiology of COVID-19: Could the Contact System Be the Key? Front Immunol. 2020; 11:2014.
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A lesson from a saboteur: High-MW kininogen impact in coronavirus-induced disease 2019. Br J Pharmacol. 2020 11; 177(21):4866-4872.