"Thrombospondins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.
| Descriptor ID |
D019699
|
| MeSH Number(s) |
D12.776.395.550.895 D12.776.543.550.895
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Thrombospondins".
Below are MeSH descriptors whose meaning is more specific than "Thrombospondins".
This graph shows the total number of publications written about "Thrombospondins" by people in this website by year, and whether "Thrombospondins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 5 | 1 | 6 |
| 2018 | 3 | 1 | 4 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Thrombospondins" by people in Profiles.
-
Serum levels of the IgA isotype switch factor TGF-ß1 are elevated in patients with COVID-19. FEBS Lett. 2021 07; 595(13):1819-1824.
-
Combined Plasmatic and Tissue Approach to Membranous Nephropathy-Proposal of a Diagnostic Algorithm Including Immunogold Labelling: Changing the Paradigm of a Serum-based Approach. Appl Immunohistochem Mol Morphol. 2020 May/Jun; 28(5):376-383.
-
Soluble stroma-related biomarkers of pancreatic cancer. EMBO Mol Med. 2018 08; 10(8).
-
Routine immunohistochemical staining in membranous nephropathy: in situ detection of phospholipase A2 receptor and thrombospondin type 1 containing 7A domain. J Nephrol. 2018 08; 31(4):543-550.
-
Genome-Wide Association and Functional Studies Identify SCML4 and THSD7A as Novel Susceptibility Genes for Coronary Artery Disease. Arterioscler Thromb Vasc Biol. 2018 04; 38(4):964-975.
-
Association analysis between thrombospondin-2 gene polymorphisms and intervertebral disc degeneration in a Chinese Han population. Medicine (Baltimore). 2018 Jan; 97(2):e9586.
-
Tissue staining for THSD7A in glomeruli correlates with serum antibodies in primary membranous nephropathy: a clinicopathological study. Mod Pathol. 2018 04; 31(4):616-622.
-
MicroRNA-221-3p, a TWIST2 target, promotes cervical cancer metastasis by directly targeting THBS2. Cell Death Dis. 2017 12 14; 8(12):3220.
-
Recent Progress in Deciphering the Etiopathogenesis of Primary Membranous Nephropathy. Biomed Res Int. 2017; 2017:1936372.
-
miR-4728-3p Functions as a Tumor Suppressor in Ulcerative Colitis-associated Colorectal Neoplasia Through Regulation of Focal Adhesion Signaling. Inflamm Bowel Dis. 2017 08; 23(8):1328-1337.